• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

I Like to Draw Pictures of Random Molecules

Status
Not open for further replies.
that's what I thought..lol guess I might have accidentlly deleted the post. will try again or use photobucket but they fcuk up that site it is so slow to load anything now..
 
DotChem said:
that's what I thought..lol guess I might have accidentlly deleted the post. will try again or use photobucket but they fcuk up that site it is so slow to load anything now..
Click to expand...

If all your links deleted at once, maybe they changed their url subsectioning methodology and it just undercut everything in your account (i.e. they're still there, the links just all broke here @ BL due to them now being under a bad url in your posts).
 
I feel like drawing something cool.

1-(3-methoxy-4-nitrophenyl)-2-methylaminopropane.png
 
yoyoman said:
I was on some random chemical research site in the USA and they had 3-CF3-amphetamine for sale... what would happen?
Click to expand...

I missed this post earlier and I guess 3-trifluoromethylamphetamine deserves a fair warning - it's norfenfluramine, an even more cardiotoxic metabolite of fenfluramine than the parent compound!
 
Drug Design 101:
Chapter 1: STIMS
Take EPH here:
Now cut the bond between the C-alfa of the piperidinyl and the C-alfa of the Ph-CH-COOEt, merge the piperidinyl at the beta carbon with the C-alfa carbon of the PhCHCOOE to get a quaternary carbon..add a para substituted fluoro..you get this:
looks a little bit like arecoline skeloton
with extra Phenyl and saturated isnt it?

Now this compound is the single most potent stim that gets as close as it gets to cocaine..I mean almost carbon copy pharmacologically (same MAT inhibition ratios, distribution profile, logP, polar surface area..etc except it is at least 50X times more potent than cocaine (the 4-Bromo probably even more 100-200x?? way more potent and faster onset of action than MPH for sure.. Don't ask me how do I know..research it and you let me know!! (disclaimer: you can go to jail if you live in US or Canada because it is analog of schedule substance!! )
Oh! one more thing: it lasts longer than Ck or MPH (the COOEt beeing now attached to a quaternary carbon is more metabolically stable toward esterases hydrolysis .. way more stable than EPH or ck possibly T1/2> 8-10 hours at least 6 I bet!
 
Last edited:
Been thinking about arylcyclohexylamines that could be potentially cool to mess around with. Most are NMDA centered (Ket-Like), some are more PCE like (the 4-HO-4'-Methyl-PCE I guess?) Which one do you guys think would be the most interesting and/or worthy of a synth? And what pharmacology profile they might have?
RcAFKBJ.png
 
Last edited:
How about just 3-MeO-PCPy? Or is that boring :D

Making something ket-like and interesting structurally is even something of a challenge, let alone the real challenge: making something that acts on hyperpolarization channels a lot like K does so that you can get real anaesthetic qualities and some 'holing' going on.

Something PCE like should be much more doable. :)
 
2-HO-2'-Oxo-PCPy sure is holing material, the 2-Meo-2'Oxo-PCPy should be even better at it! Also I was wondering about the 2'-Methyl groups, they might replicate (to some extent) the Oxo group when at the glutamate receptor, like the chloro group does with Ketamine.
 
sekio said:
that compound is actually the meta- isomer of desmethylpethidine/meperidine/Demerol, it's an opioid i think?
Click to expand...
No actually this (and similarly substituted 3-phenylpiperidines with a secondary amine NH) have no opioid activity but are potent SNDRIs (IC50~2-5nM v Coacaine ~140nM. But yeah. it looks like meperidine or more precisely nor-meperidine but substituted on the 3 position. While meperidine is an opioid, Nor-meperidine has NO opioid activity at all.
Norpethidine is a controlled drug because of its potential uses in manufacturing both pethidine itself and a range of N-substituted derivatives, but it has little opioid activity in its own right. Instead, norpethidine acts as a stimulant...(norpethidine wikipedia)
Click to expand...
Also, moving the N from the 4 to the 3 position kills opioids activity in this series even with a tertiary amine like in meperidine. So theses are pretty much totally devoid of opiod..(would post ref SAR later
But on the other hand, nor-meperidine (and related 3-PP) are potent SNDRIs. Comparable to phenmetrazines which are 3-phenyl substitued piperidines also. More exactly morpholines! But unlike phenmetrazines (like 3FPM) which are DA/NE releasers, the Carbetoxy makes them very much MPHcokePVP-like with DAT current reversal...
 
amine-Copy62ffe.png


I recently acquired a gram of the above molecule. MEPEA (no bromine at the 5-position) is slightly active at 300mg, so perhaps this compound is a little more interesting. Depends on how good bromine is at accepting a hydrogen bond (which is what the OMe group is doing here in mescaline when in docks with 5-HT2A, if I understand correctly). -SMe seems to work, as in 3-thioescaline, and bromine isn't far off from the methylthio group in steric bulk and polarizability...
 
Bromine does not accept hydrogen bonding. That only occurs on the FON--with fluorine, oxygen, and nitrogen.
 
R39MPAg.png


N-(4-Fluoro-Phenylpiperazine)-5-Meo-Tryptamine
5-Meo-PFPT

Quite straight forward if some ching wants to try it, just need 5-HTP, reduce it to N-cyanide, react it with 4FPP, then methylate 5-HO.
 
Last edited:
^--Very interesting.

I know that 1-(3-chlorophenyl)-4-(2-phenylethyl)piperazine

1-(3-chlorophenyl)-4-(2-phenylethyl)piperazine.png


has been reported in the literature to be a *ridiculously* potent DRI.

Makes me think of 1-(3-chlorophenyl)-4-(2-(indol-3-yl)ethyl)piperazine

1-(3-chlorophenyl)-4-(2-(indol-3-yl)ethyl)piperazine.png
 
Thanks, I appreciate.

Edit: it might just be better than the foxy lady
Last edit: China should try to synth these N-(sub'd-phenylpiperazines)-4/5-sub'd-tryptamines instead of throwing out shite like u-48800. I'd love to try it out à la shulgin.
 
Last edited:
Status
Not open for further replies.
Top