I Like to Draw Pictures of Random Molecules

[Nagelfar]

Interesting. Many quaint changes to m-amp that are being overlooked IMHO, good aim/eye, Dres.

EDIT:

N-cis (methyl = R-one, hydrogen = R-two) or trans: (methyl= R-two, hydrogen = R-one) propenyl-amphetamine

A username "The Aliphaticman" with this avatar and the signature "I Am Not An Aminal" would be a great one for BL

(over at opiophile I made a thread with such suggestions: one was a little orphan Annie avatar with an arm holding a gun to her head and the username "End-orphans" ;-p)

...Well, anyhow, The Elephant man is an apt metaphor for my molecular catastrophes I'd wager.

 

[Solipsis]

Too late, Annie has already been serial-massacred by Dexter the meth orphan.
Orphans are so curious among each other. Cf orphan black (= surprisingly NOT batman).

I smiled at the aliphaticman but you do realize that hemiaminal ether is aliphatic, right? It's just not alicyclic.

---

(RS)4-fluoro-N,α-dimethyl-cyclohexylethylamine

SMILES = FC1CCC(CC1)CC(C)NC

(2S)2-ammonio-3-(piperidinon-3-yl)propanoate

SMILES = [NH3+][C@H](C(=O)[O-])CC1C(NCCC1)=O

Looks cooler ring-closed and lactams aren't so common in drugs I know of, ring opened hopefully still carried by amino acid transporter, you can guess what this is modeled after and on what system it may have effect, though perhaps only in ring-closed form? Edit: sorry mistaken, ring closure doesn't apply

Possibly a form of nylon could be made from it.. : p
Though not in vivo, otherwise someone should write a paper on mending internal wounds by injecting a patient with lactams, and glueing the stuff together with acrylfentanyl.
(speaking of materials like that)

1-propionyl-3-[2-(Dipropylamino)ethyl]-1H-indol-4-yl propanoate

SMILES = C(CC)(=O)OC1=C2C(=CN(C2=CC=C1)C(CC)=O)CCN(CCC)CCC

This drug was the runner up in the competition for the name 'substance P'

 

[clubcard]

Hey people - images are a BULKY way to exchange images. I feel certain that whatever editor you're using will give you the SMILES data &/or the IUPAC naming convention. With these, you can quickly search for the name in patents, Google Scholar or Reaxys. It's about 20x faster to swap data AND their is java SMILES ->Image.

This means that the image above 6.83Kb (rounded up to 8Kb because of HD formatting)is, in SMILES CCCN(CCC)CCC1=CN(C(=O)CC)C2=CC=CC(OC(=O)CC)=C12 into 47 characters which could be physically stored even smaller by a simple Huffman tree (or an arithmetic tree now patent expired). Don't generate a tree for each image, just the best-fit from 255 trees themselves chosen by scanning through chemicalize.org. I would expect to get at least 70% compression since we virtually only use a set containing a small number of elements (11 give or take) and a small number of bonding types (about a dozen). I mean, everyone can SEE the image & copy and paste it into some other software. I have never had the need to use InChI or InChI key but that needs a straw poll.

I know I keep going on about it but if the software is available but their are Python scripts to do this. 6K seems nothing, but if the site generates the images, they won't disappear when a link breaks or the thread is archived. I've not seen the PHP running the site or how complex inclusion would be, but I think if people had it & could export it, it leads on to people buying the Student edition of ChemOffice and all you guys in collage can throw it in Reaxys.

If I'm just the 1 person who can see the importance, I can also add that when it's used in Marvinsketch (or Chemoffice) then the cLogP & pKa at blood pH can quickly edit a compound that fulfil's the rules of 5 so you're learning by doing, While we cannot give any synthesis information, so often the answer is in a patent or a paper so adding on the source data also cuts a pathway for all who follow,

 

[Solipsis]

While some ideas are definitely titillating, I think one reason why this thread exists is because amateurs also like coming to this forum to share wacky ideas, hence the 'random molecules' in the title rather than 'amazing novel psychoactives that should theoretically work and everything!', well yeah also the latter is too long.

I added SMILES for the hell of it ^ but for your fine idea to work I think this first would have to split into an amateur / entertainment thread and a serious new ideas thread - like differentiating between business and pleasure at the airport, or social talk from drug addled ramblings in PD.
I don't think splitting them isn't particularly desirable, though I understand if it's annoying if you strictly love the nonsense or the sensical here.
And often people here react to fun ideas from less than educated people as if they were submitted to be analyzed as a candidate for actual synthing or assaying. Which is a little like completely missing someone's sarcasm on a forum for some reason..

The lines are a bit blurry, and I think it's fun that way, I like the entertaining ideas as much as the serious possibilities that appeal to the imagination.

Otherwise any change like that, which ignores half of the public, would be pretty unfair?

 

[DotChem]

Here's a nightmare drug.

what's the pb with it? ..it looks so similar to foxy!

 

[Solipsis]

'spirobarbital'
(RS)-12-methyl-2,4-diazaspiro[5.6]dodec-8-ene-1,3,5-trione
CC1CCC=CCC12C(NC(NC2=O)=O)=O

Let's LSZ-tidize that bastard and get the constrained winner..

Or another avenue below - doesn't even have to be 'symmetrically' bridged..
Omitted the terminal methylene this time cause it doesn't really look right to me (polymerization? alkylation?)
But perhaps chloro is more of a sub

3-fluoro-1,2-dimethyl-7,9-diazaspiro[4.5]decane-6,8,10-trione
FC1C(C(C2(C1)C(NC(NC2=O)=O)=O)C)C

what's the pb with it? ..it looks so similar to foxy!

https://www.erowid.org/library/books_online/tihkal/tihkal52.shtml
https://www.erowid.org/library/books_online/tihkal/tihkal43.shtml

It actually kinda shows that sometimes 'constraining' (bridging really) two chains together gives you a weird acting compound... although the dimethylazetidine is still exciting to check out, again a la LSZ probing research.

I submit this (maybe as IP injection?) for nightmares:

diphenyl(piperidin-2-yl)methyl palmitate

maybe the adamantane dicarboxylate bis pipra is twice as 'good'

 

[DotChem]

https://www.erowid.org/library/books_online/tihkal/tihkal52.shtml
https://www.erowid.org/library/books_online/tihkal/tihkal43.shtml

It actually kinda shows that sometimes 'constraining' (bridging really) two chains together gives you a weird acting compound... although the dimethylazetidine is still exciting to check out, again a la LSZ probing research.

Horrible compound! light-years away from foxy glow. amazing how small changes can have big impacts! Dimethylazetidine seems good alternative.. or even the dimethylpyrrolidnyl? I guess it will be closer to 5MeODIPT in terms of steric, electronic logP..etc..but who knows how they'll behave once they cross BBB!

 

[Midnight Sun]

what's the pb with it? ..it looks so similar to foxy!

https://en.wikipedia.org/wiki/5-MeO-pyr-T

it's barely even active

@ solipsis - curse you, I was coming in here to post a pipradrol ester

 

[Dresden]

It caused one of Sasha's subjects to wander the streets for I forget how long in a fugue state replete with amnesia, so how can you call it "barely active"?

 

[Midnight Sun]

It caused one of Sasha's subjects to wander the streets for I forget how long in a fugue state replete with amnesia, so how can you call it "barely active"?

sum total of effects: nausea, vomiting, amnesia (?)

ok, that's about as active as the shit I took this morning would be if I loaded it into a pipe and smoked it

 

[Nagelfar]

early never-marketed/discontinued anti-depressants with interesting skeletons:


Tranylcypromine


Carbenzide


Isocarboxazid


Iproniazid


Metfendrazine


Domoxin


Cimemoxin

Cf orphan black (= surprisingly NOT batman).

I smiled at the aliphaticman but you do realize that hemiaminal ether is aliphatic, right? It's just not alicyclic.

Humans are animals, taxonomic genus "Homo", I am as right/correct as the Elephant Man; but I'm not his clone (I hope, my mirror is the same as Shallow Hal's if not)

 

[sekio]

tranylcypomine is still in active use

 

[Nagelfar]

tranylcypomine is still ina ctive use

Interesting. The cyclopropane on it. Wonder what modification'd be needed to make a dopaminergic instead of an MAOI

 

[roi]

 

[Solipsis]

There are RCs available that are close analogues of tranylcypromine:

the 4-methyl (or rather 4'-methyl with the cycloprop being main ring) - so a mephedrone tolyl style compound, and
the 3,4-fluoro (3',4') - cause 3,4-fluoroamph is so well known and popular

Both of which are scary as they are about half as potent MAOIs as the parent and I don't know what other activity they possess that would contraindicate with MAOI.

I really don't like seeing analogues like that.

 

[aced126]

Tranylcypromine is a DRA. It would have to be a dopaminergic because has to enter dopaminergic neurons for its mechanism of action (inhibiting cytosolic MAO-b) to take place. Once in the neuron it needs to release DA from vesicles as well as reverse the function of DAT, which it does but only 10% as efficacious as amphetamine itself.

 

[crmt28]

I'm too lazy to draw the structure, but is there any reason we've never seen any benzodiazepines with iodine atoms?

The only thing close is iomazenil, but that's a Flumazenil (antagonist!) analogue with an iodine atom instead of fluorine.

 

[Dresden]

 

[Solipsis]

Funny hybrid of methamp and arylcyclohexylamines..
Looking at beta-methylamphetamine putting more on the beta may just really weaken it to the point of nothingness or even do strange things for blood pressure?
As a dissociative... it's not an n-methyl aspartic acid analogue but if anything a step in the direction of glutamic acid? Glutamate agonists could be neurotoxic so thatd be awkward, but its missing a lot of similarity for that. Also then I'd expect the diphenidines to be risky as well in that sense, plus many more compounds.
Nothing to do with that spacer really, but put a 2'-oxo on there while you're at it? :D overlap with glutamate would be extra funny

@iodo benzo's:

Should work as electron withdrawing groups on the 7- and 2' position increase potency, and 2'-iodo diazepam has 9x affinity of diazepam - even higher than of flumazenil.
I've had a highly 7 / 2'-position electronegative diazepam analogue I cannot name and it was active in the 100 µg range but also seemed to precipitate withdrawal symptoms a little, making me suspect it's a mixed agonist/antagonist which is not atypical for high affinity ligands. When a drug binds very strongly, it doesn't continue to keep increasing net activation just like hugging someone is not always the more pleasant the longer they continue to hang on. For an antagonist there may not be activation at all, or even if there is for some drugs - the drug may occupy the site for so long that endogenous ligands would have caused more activation per saldo. Correct me if I'm wrong.

I don't know if the actual action of those super benzo's have been explored or if this tendency is understood by drug designers and psychopharmacologists... but it could be why 7,2'-diiodo benzos might be absolute monsters. Then again, there exist ultra potent agonists without having that mixed agonism/antagonism or plain antagonism.
Do they keep the receptor in an activated conformation? Are they just that 'good' ?

 

[crmt28]

Triazolos

Iobromazolam / Ionazolam / Diiodotriazolam

2-Keto

Iobromazepam / Ionazepam

1-Methyl-2-Keto


Diiodazepam / Iodiazepam