• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

I Like to Draw Pictures of Random Molecules

Status
Not open for further replies.
Have there ever been ultra long lasting versions of opioid receptor antagonists, or buprenorphine?

Similar to the decanoate ester versions of antipsychotics like haloperidol?

Could this help people detox without having to have a daily dose of something?
 
Sorry guys I'm tweaking and found a free super easy chemdraw! Why haven't one of you synthmeisters produced these yet? Just shut up and take my money!

2mx3192.png

I happen to be one of the few people who actually thought DMAA was kind of great recreationally. It seems to have affected me quite differently from other people; I actually got an opiate-like very pleasurable long lasting high with some hints of some MDMAish effects at 100mg oral. My uptake is very efficient / I have a very low tolerance / my kidneys might be fucked.

Put me on my ass, just lay around on the couch all day sighing from pleasure because everything felt so great that I couldn't concentrate. Alas, didn't feel too healthy.

No I'm not tweaking on DMAA right now it's not tweaky.
 
Ok so that should have been 5,6-methylenedioxy-4-methyl-hexane-2-amine? And it would be an "analogue" of 2,3-MDA instead of the good one. What if you lengthen the hexanamine to a heptanamine so you can have a 6,7-methylenedioxy?
 
Last edited:
DrPonzi said:
Here are some novel compounds that will blow your mind:
4e2g.png
Click to expand...

I like Nitroglyscaline, but shouldnt it be something like Trinitroglyscaline? Nitroglyscaline should have methoxy groups at 3 and 5. Also, is it even possible? and when will then 2C and NBOME versions be out? Price per gram? Just joking about those last two sentences...

Also anyone wanna talk about possible activity / possibility of even being created of the 2C with an amine at the 4 position he posted?
 
That 4-ethylamino 2C is one of the cornerstones of elementary chemwank, been posted time and time again. I don't see why anyone would want a cathinone/dmaa hybrid, and I don't fancy the stability of the MD ring without an aromatic cycle next door. Also, not entirely sure, but that nitroglyscaline might have the potential to really blow you away.
 
aAAyl53.png


First two are just random structures I drew because I liked the look of them, third is self explanatory though dunno if it'd be active. :p
 
Holy hypervalent chlorine, Batman! The last one, I imagine would be active, but not very good, and probably rather long-lived. Without that extra carbon in the middle, that second one could be a kind of arylalkylamine, sort of a PCP-looking thing:
JtWjS.png

though AFAIK pyrollodine leads to drastically reduced potency over the piperidine, and without a chyclohexane ring it probably wouldn't work at all (take this with a pinch of salt, SAR/chem in general is not my strong suit).
 
Yeah, that third one seems pretty similar to MDPPP which, let me tell you, sucks. I have never seen a drug with a pyrrolidine ring that I liked.
 
Hi everyone,

Long time lurker, first time poster here. As much as I love all of Bluelight, this thread has always been one of my favourites, because among all of the random chemwanks that are posted, I have noticed more than a few that have some real promise, at least in my opinion. I do have a fair bit of o-chem experience, and while I have often thought up some funny and almost certainly useless compounds over the years, occasionally I do come up with something that I would like to taste, or at least see explored in more detail. I'd like to make my first post here one that provokes some discussion, even if the SAR behind it is perhaps flawed. So I bring you my first public monstrosity: the DMT-with-the-n-pharmacophore-of-ketanserin-thing!

u4gx.png


The logic behind it is as follows: Ketanserin is a 5-HT2a antagonist (among other things), but when the (1-ethylpiperidin-4-yl)(4-fluorophenyl)methanone pharmacophore is replaced with the 2-methoxybenzyl one from the NBOMe series, the activity at 5-HT2a is switched from an antagonist to an agonist. When the n-benzyl pharmacophore is applied to a tryptamine, such as with 5-MeO-NBpBrT, the result is a highly selective 5-HT2a antagonist. Could it be possible that the (1-ethylpiperidin-4-yl)(4-fluorophenyl)methanone pharmacophore, when attached to a tryptamine, could possibly have an interesting effect while retaining a reasonable level of selectivity for 5-HT2a and agonist activity? Probably not. From my understanding, there is not very much tolerance for bulk at that position with tryptamines, at least if you want agonist activity at 5-HT2a. Still, it's an interesting idea. I would appreciate any insights or ideas that anyone may have.
 
Status
Not open for further replies.
Top