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Opioids I have a scientific theory on the function of opiates.

ah. well perhaps so, they are all interconnected to opiate receptors which as you obviously are aware of are our natural way to prevent pain. in times when we are critically injured we will produce a large amount of it ourselves in order to dull the pain away so that we can get away from danger without feeling the injuries we could have sustained too.
 
That's right, and it just seems to me to be more than coincidental that all the other effects of opiates having to do with supressing motion of some kind must be there for a reason.
 
Opiates also stimulate the vomiting centers in your brain....do you consider vomiting to be particularly advantageous while critically injured?
 
Opiate withdrawal stimulates vomiting which proves my point. Most people would not vomit unless they o/ded, and even so the natural levels of endorphins do not trigger emesis.
 
@romealone@
Hell yea, is absolutely advantageous to vomit, especially If it was dark when you picked those mushrooms and you just so happen to eat the only one in the whole cow pasture that could kill you. Otherwise I can't think of any injuries that would benefit from puking. Also when intense pain, if it reaches high enough levels vomitting is uncontrolable. Why is it that extremely severe pain causes us to vomit?
 
@bomb319
It is common practice for physicians to prescribe antiemetics with opiates, especially in opiate naive patients. When admitted to the hospital for massive bodily injury doctors will administer Demerol and phenigran together. You don't have to od to become nauseated from opiates, however most people on these forums haven't felt nauseous from opiates in quite some time if ever.
 
Bomb319 said:
Opiate withdrawal stimulates vomiting which proves my point. Most people would not vomit unless they o/ded, and even so the natural levels of endorphins do not trigger emesis.
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People do get nausea from opioid drugs, the degree depends on the person, whether or not they use the drug regularly, the specific opioid (and several other factors) and it absolutely can happen even in normal doses, not just overdoses. It normally happens when you aren't tolerant to an opioid. For example, until recently I had been using opioids for many many years and it was a very long time since I got any nausea from opioids except when I would take an oral opioid that I wasn't used to, I would get very nauseous from a dose that was so low it didn't even completely alleviate withdrawals. It is weird that nausea/vomiting are both side effects of opioids and effects of withdrawal. So not every withdrawal symptom is the opposite of the effects of opioids, it's a little more complicated than that.

I would say the nausea/vomiting thing doesn't prove anything, I would just discard that one. It doesn't necessarily prove your general theory wrong, and as you said natural endorphins don't tend to cause nausea/vomiting - or do they?? it has been suggested that in large amounts they might, like when someone is seriously injured or over-exerts themselves through exercise, but that is just a theory I read that has not been proven (the nausea/vomiting in those cases could be due to other factors). It is interesting that both opioid drugs and endorphins cause a histamine release (obviously it's much greater with drugs), and the histamine release is likely the cause of the nausea.
 
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Buddha_hotei_boy said:
@bomb319
It is common practice for physicians to prescribe antiemetics with opiates, especially in opiate naive patients. When admitted to the hospital for massive bodily injury doctors will administer Demerol and phenigran together. You don't have to od to become nauseated from opiates, however most people on these forums haven't felt nauseous from opiates in quite some time if ever.
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Very well said.
 
i think vomitting is a very useful tool in terms of extreme survival at times of desperation. if for instance you ate food that would poison you or make you sick in the imminent future say you had access to chicken and you'd undercooked it, salmonella or whatever - being able to remove all the crap from your stomach before it's absorbed is a very vital skill.
 
I haven't gotten nauseous from opioids in like a year or two, and before that it was only during quasi-OD situations. I used to get nauseous when I started slamming opis dope n coke

Good antiemetics for me from most to least effective: ondansetron, chlorpromazine, promethazine, hydroxyzine.

All good with opioids and RXd all the time by my pain management clinic
 
tricomb said:
I haven't gotten nauseous from opioids in like a year or two, and before that it was only during quasi-OD situations. I used to get nauseous when I started slamming opis dope n coke

Good antiemetics for me from most to least effective: ondansetron, chlorpromazine, promethazine, hydroxyzine.

All good with opioids and RXd all the time by my pain management clinic
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Yeah, odansetron is a big help to me when I need it. I had a few stashed incase I needed them for a kick but I gave um' to my chic.
 
Same, I always keep Zofran on hand, 8mg sublinguals. On the topic of opiates and withdrawals and everything, Ondansetron actually relieves a lot of opiate withdrawal symptoms for me, like it handles some of the general dysphoria, RLS, any nausea you might have and diarrhea even helps a bit for that too.

Not sure how it does it, it's a serotonin HT-3 antagonist, affecting both central and peripheral nerves. It has no effect on dopamine or muscarinic acetylcholine receptors.
 
The mechanism behind opioid induced vomiting is well understood:

http://www.ncbi.nlm.nih.gov/pubmed/19302436

Look into domperidone an antidopaminergic, antiemetic, which acts on chemoreceptors trigger zones. One of the sites mentioned in this study. This drug works like no other in blocking nausea and vomitting induced by opioids.
 
Vomiting is basically your body's most primitive and major disaster control mechanism. It's essentually a natural stomach pump, and is very advantageous for survival if you are in sudden distress due to gastrointestinal blockage, poisoning, etc. Extreme pain due to trauma is a little tougher to understand why vomiting in this case would be beneficial, but I suppose that nausea prevents you from eating if you're fighting a critical injury and desperately need the blood flow to the injured area and not diverted to digest a meal?

I don't know, I just pulled that theory out of my ass but there must be a reason.
 
This theory is... awesome. It makes total sense to me and I can definitively attest to opiates stopping yawning, eyes watering, and other things that seem insignificant. In the 6 years or so I've been on Subutex, the ONLY time I EVER yawn (or eyes water) is when I need a dose of bupe.

I've always wondered what the hell shitting, yawning, and coughing had to do with pain. I knew it must have something to do with it because the word endorphin literally means 'morphine within'. Opiates and endorphins work on the same receptors. And it's possible that endorphins could be even stronger than opiates because the state of shock can completely block the pain of a bullet to the kneecap, and instantly I might add. Now it would take one massive fucking IV shot of heroin to do that.

Healing process involves laying around, resting, being lazy for good reason, ect.
Opiates make you wanna... lay around, rest, and be lazy for no good reason.

Coincidence? I think not. Nice work bomb.
 
Bomb319 said:
Vomiting is basically your body's most primitive and major disaster control mechanism. It's essentually a natural stomach pump, and is very advantageous for survival if you are in sudden distress due to gastrointestinal blockage, poisoning, etc. Extreme pain due to trauma is a little tougher to understand why vomiting in this case would be beneficial, but I suppose that nausea prevents you from eating if you're fighting a critical injury and desperately need the blood flow to the injured area and not diverted to digest a meal?

I don't know, I just pulled that theory out of my ass but there must be a reason.
Click to expand...

Seems far fetched.
 
Lol you're telling me in 6 years you haven't yawned once aside from bupe w/d?

I will attest to having yawned, sneezed, had a runny nose and watery eyes. Both from needing my sub (I will freely admit this is a culprit every time I drop my dose), as well as just from regular existence.
 
DooMMooD said:
Lol you're telling me in 6 years you haven't yawned once aside from bupe w/d?

I will attest to having yawned, sneezed, had a runny nose and watery eyes. Both from needing my sub (I will freely admit this is a culprit every time I drop my dose), as well as just from regular existence.
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EDIT: Nevermind, see below
 
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This is what your getting at and I have read up on this before. When getting high on opioids they trick our brain into thinking we are going through life threatening pain and anguish. Basically the good feelings that opiates produce are all naturally occuring in our body already, but they force a major very large release of these chemicals. What I mean is, if your in the woods, and you recieve a terminal wound and there is nobody around to save you, your body releases the same chemicals as the opiate high does, just in less amounts and not as rapid. So in conclusion the high achieved from opiates is because your tricking your body into having to release chemicals that would help you survive when terminally wounded.
 
Swimmingdancer said:
No one said opioids completely prevent you from yawning, sneezing, or coughing.
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That is LITERALLY what this guy said:

dhopeless said:
This theory is... awesome. It makes total sense to me and I can definitively attest to opiates stopping yawning, eyes watering, and other things that seem insignificant. In the 6 years or so I've been on Subutex, the ONLY time I EVER yawn (or eyes water) is when I need a dose of bupe.
Click to expand...

So yes, someone did say that.
 
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