I have a question about tramadols interaction with dissociatives.

[phenethylo J]

I am perscribed tramadol along with several other medication for severe chronic pain. I know that dissociatives such as pcp, mxe, and dxm interact pretty bad with tramadol do to their nmda receptor activity. From what I read and my own personal experience ketamine doesn't interact bad with tramadol. I was wondering why exactly ketamine doesn't have the same bad interaction with tramadol since ketamine also acts on the nmda receptors like pcp, mxe, and dxm do.

I would love to try mxe and have acess to it but am scared because of this. I remember some one on here saying that tramadol caused extreme potination of mxe when they mixed the two.

 

[sekio]

Tramadol will probably potentiate most arylcyclohexylamine dissociatives (Ketamine, PCP, MXE) but I don't advise combining it with DXM because of the strong SNRI effects that can present. (Leading to serotonin syndrome).

 

[psychoblast]

This thread has me concerned. as I have been taking mxe daily (oral, 40mg at 3pm, 40mg at 6:30m) and tramadol about every other day (100mg at about 10:30am) for about 9 months. Is it a problem to combine tramadol & mxe?

 

[sekio]

Obviously not for you.

80mg mxe daily is a lot, though.

 

[ebola?]

Tramadol will probably potentiate most arylcyclohexylamine dissociatives (Ketamine, PCP, MXE)

Is this due to secondary activity of tramadol (or o-desmethyl-tramadol) as an NMDA antagonist?

ebola

 

[sekio]

Yes, I think so. That and the u-opioid action of tram is potentiated by NMDA blockade of arylcyclohexylamines too.

 

[phenethylo J]

I know about the potentiation but what I was asking was would you concider the potination to be allot more dangerouse and stronger with mxe. I rember reading on bl that someone said they took mxe on tramdol and just 3mgs hit them very hard, and a strong dose is actualy around 40mgs.

 

[negrogesic]

Tramadol tends not play well with other children as a whole. DXM should never be used in concert with tramadol.

There are a number of potential issues than could occur with the coadmin of tramadol and dissociatives like MXE, etc.

Nitrous oxide is likely the safest dissociative than can be used with tramadol.