• Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Opioids Hydrocodone dosage (I don’t get high?)

creepycat98

Greenlighter
Joined
Feb 9, 2025
Messages
5
I was prescribed hydro 7.5s have 6 left and want to get high.


Here’s the issue, opiods don’t ever seem to work for me? I’m a male, 26, 5’11 185lbs.
I typically do benzos because they always did what I wanted them to, I have done opiods to the extent of:

Prescribed Percocet 5s (up to 20mg dosage)
Prescribed hydrocodone (up to 30mg)
Someone’s grandmas hydros (up to 80mg)
Street Percocet that I believe was real (10s &20s up to 80mg)
ODSMT (unsure of dose)

The only time I felt anything close to euphoria or relaxation was on the ODSMT. I only got nauseous from 80mg oxy. I have never gotten that warm fuzzy feeling. I know I should be thankful to not have the addiction to opiods but I have my battles with other substances.

When I took the prescription Percocet I thought maybe I didn’t get much of an affect since my body had been gettting IV dilaudid for a few days in hospital, (no crazy affects there either besides feeling heavy for a bit)

I wonder if I didn’t feel other substances because I started with too low of doses like 10-20mg oxy several times and developed a tolerance before I reached correct dose.

I haven’t done any drugs recreationally apart form weed in 6 months. And taken 15mg hydro a day for last few days.
How can I assure the best outcome for my planned 45mg hydrocodone dose? And why do you think I don’t ever get that warm fuzzy feeling of wellbeing everyone talks about in opioids?
 
I don’t have an idea, but 45 mg really sounds like an overdose type situation that I wouldn’t risk. As long as you aren’t dependent why don’t you set aside the pills for four weeks and try taking just 15 mgs after being sure that you’re completely opioid naive.

I once took an 80mg oxy and all I got was weepy. It never affected me like the oxy I would one day become addicted to. I don’t really know the mechanism behind this but 15mg oxy at a later point in my life hit so much harder than an 80mg at that younger age.

Please be careful. 45 mg is a huge dose of hydro

Do you by any chance take kratom?
 
Also the street Percocet could have been counterfeit and you may have developed a tolerance via fentanyl in the tablets.

One last question, are you taking the hydros orally?
 
If this has been an unbroken string of use then you may be carrying a tolerance. You typically need 2-4 weeks to become completely opiate naive again.
 
I don’t have an idea, but 45 mg really sounds like an overdose type situation that I wouldn’t risk. As long as you aren’t dependent why don’t you set aside the pills for four weeks and try taking just 15 mgs after being sure that you’re completely opioid naive.

I once took an 80mg oxy and all I got was weepy. It never affected me like the oxy I would one day become addicted to. I don’t really know the mechanism behind this but 15mg oxy at a later point in my life hit so much harder than an 80mg at that younger age.

Please be careful. 45 mg is a huge dose of hydro

Do you by any chance take kratom?
No I don’t take any kratom, yes I am taking them orally, and I took 21.5mgs the first day I got the script last week and felt nothing. So I continued taking it as prescribed 15mgs a day for 2 more days. Then a week off and just got the second stript.
 
No I don’t take any kratom, yes I am taking them orally, and I took 21.5mgs the first day I got the script last week and felt nothing. So I continued taking it as prescribed 15mgs a day for 2 more days. Then a week off and just got the second stript.
Damn I really don’t know.

Aside from the iv dilaudid have you used any other opiates in the last month?

I mean it’s even odd that you got nothing out of iv dilaudid. A lot of people on here claim that stuff to be amazing.

Seems like somehow your tolerance is really high or maybe you don’t have the brain chemistry to experience opioids in the same manner as other people.

@negrogesic

What do you make of this?

This guys one of the more knowledgeable dudes on the site. He might be able to help.
 
Damn I really don’t know.

Aside from the iv dilaudid have you used any other opiates in the last month?

I mean it’s even odd that you got nothing out of iv dilaudid. A lot of people on here claim that stuff to be amazing.

Seems like somehow your tolerance is really high or maybe you don’t have the brain chemistry to experience opioids in the same manner as other people.

@negrogesic

What do you make of this?

This guys one of the more knowledgeable dudes on the site. He might be able to help.
No, and that IV dilaudid was over a year ago. I haven’t done any opioids in over 6 months besides a week ago I took 7.5mg of hydro 2x a day after one day of that I took 21.5mg one morning on empty stomach didn’t feel anything at all
 
No, and that IV dilaudid was over a year ago. I haven’t done any opioids in over 6 months besides a week ago I took 7.5mg of hydro 2x a day after one day of that I took 21.5mg one morning on empty stomach didn’t feel anything at all
Are you taking any other medications?
 
Yes, some individuals have genetic or physiological differences that make them less responsive—or even completely unresponsive—to opioids. Several factors can contribute to this:


1. Genetic Variability in Opioid Receptors


• The OPRM1 gene encodes the mu-opioid receptor, the primary site where opioids exert their effects. Variations in this gene can reduce opioid binding or signaling, making opioids less effective or even ineffective.


• For example, the A118G polymorphism in OPRM1 is associated with reduced opioid sensitivity in some populations.


2. Differences in Metabolism (Cytochrome P450 Enzymes)


• Opioids like codeine, oxycodone, and tramadol are prodrugs that require activation by the liver enzyme CYP2D6 to become their active forms (e.g., morphine from codeine).


• Poor metabolizers (due to genetic variants in CYP2D6) may not convert these drugs effectively, leading to little or no pain relief.


3. Increased Pain Sensitivity (Opioid-Induced Hyperalgesia or Neuropathic Pain)


• Some people experience paradoxical effects, where opioids make pain worse instead of relieving it.


• Neuropathic pain conditions sometimes do not respond well to opioids because they involve nerve damage rather than traditional pain pathways.


4. Tolerance and Receptor Downregulation


• Chronic opioid users may develop tolerance, meaning they need higher doses for the same effect. However, in some cases, receptors become so desensitized that opioids lose their efficacy entirely.


5. Psychological and Neurological Factors


• The perception of pain is influenced by brain chemistry, mood, and expectation. People with high endogenous opioid activity (naturally high endorphins) or certain psychological traits may not feel much effect from opioids.





Would you like me to elaborate on any specific factor?




It might be that you’re the type two kind of person with the problem with metabolizing opioids.

As I understand it o-dsmt is the metabolite of tramadol so it makes sense that taking that you felt something.

But hydrocodone requires breakdown in the liver



Hydrocodone is metabolized by CYP2D6, but unlike codeine and tramadol, it does not fully rely on it for activation. Here’s how it works:


• CYP2D6 converts a portion of hydrocodone into hydromorphone, which is a more potent opioid and contributes to its pain-relieving effects.


• However, hydrocodone itself is already active and binds to opioid receptors, meaning CYP2D6 metabolism is not essential for its effectiveness (unlike codeine, which must be converted into morphine to work).


• CYP3A4 also plays a role, breaking hydrocodone into less active metabolites.





CYP2D6 Variability and Hydrocodone Response


• Poor metabolizers (PMs) of CYP2D6 (those with low or no enzyme activity) may experience weaker pain relief from hydrocodone because they produce less hydromorphone.


• Ultra-rapid metabolizers (UMs) may convert hydrocodone into hydromorphone too quickly, potentially leading to stronger effects or side effects.





So while CYP2D6 contributes to hydrocodone’s potency, it is not required for the drug to work, and its analgesic effect is still present in poor metabolizers, just potentially weaker.



But it seems to me that dilaudid should have worked on you

Dilaudid (hydromorphone) does not require CYP2D6 for activation because it is already in its active form. Unlike codeine, tramadol, or even hydrocodone (which partially depends on CYP2D6 for conversion into a more potent metabolite), hydromorphone works directly at opioid receptors without needing metabolic activation.





How Dilaudid Is Metabolized


• Hydromorphone is mainly metabolized in the liver by glucuronidation (via UGT2B7) into hydromorphone-3-glucuronide, which is inactive.


• CYP enzymes, including CYP2D6, play little to no role in its metabolism.





Implications


• CYP2D6 poor metabolizers (PMs) and ultra-rapid metabolizers (UMs) will generally not experience significant differences in response to hydromorphone.


• Patients who do not respond well to codeine or hydrocodone due to CYP2D6 issues may still get effective pain relief from hydromorphone.






So my best thinking is that you have a problem metabolizing opioids in your liver.

Something like this might be true for you.

If you don’t feel the effects of hydrocodone, several factors could be at play. Here are the most likely reasons:





1. CYP2D6 Poor Metabolism (Reduced Conversion to Hydromorphone)


• Hydrocodone is partially metabolized by CYP2D6 into hydromorphone, which is more potent.


• If you are a CYP2D6 poor metabolizer (PM) (due to genetic variations), your body may not efficiently convert hydrocodone into hydromorphone, leading to reduced pain relief.


• You can get a pharmacogenetic test to check your CYP2D6 status.





2. CYP3A4 Overactivity (Rapid Breakdown of Hydrocodone)


• Hydrocodone is also broken down by CYP3A4 into an inactive metabolite.


• If your CYP3A4 activity is high, hydrocodone might be metabolized too quickly before it has time to work.


• Certain medications (e.g., rifampin, St. John’s Wort) can increase CYP3A4 activity, making hydrocodone less effective.





3. High Opioid Tolerance or Natural Insensitivity


• If you’ve used opioids before, you may have a higher opioid tolerance, requiring a stronger dose.


• Some people have naturally lower opioid sensitivity due to genetic variations in the OPRM1 gene (mu-opioid receptor).





4. Pain Type (Neuropathic Pain or Hyperalgesia)


• Hydrocodone is most effective for nociceptive pain (injury, surgery, inflammation).


• Neuropathic pain (nerve damage, fibromyalgia) often does not respond well to hydrocodone or opioids in general.


• Opioid-induced hyperalgesia (OIH) can paradoxically make pain worse instead of better.





5. Absorption and Other Physiological Factors


• If you have gastrointestinal issues (e.g., gastroparesis), your body might not absorb hydrocodone efficiently.


• Food and pH levels in your stomach can also influence absorption.





What You Can Do


• Try a different opioid: Since hydromorphone (Dilaudid) doesn’t rely on CYP2D6, it may work better for you.


• Consider non-opioid pain management: Depending on the cause of your pain, other medications (e.g., NSAIDs, gabapentinoids, SNRIs) may be more effective.


• Get pharmacogenetic testing: This can determine whether CYP2D6 or other enzymes are affecting your drug metabolism.



i used chat gpt to kind of help me with some of the research arriving at the problem metabolizing opioids hypothesis.
 
Yes, some individuals have genetic or physiological differences that make them less responsive—or even completely unresponsive—to opioids. Several factors can contribute to this:


1. Genetic Variability in Opioid Receptors


• The OPRM1 gene encodes the mu-opioid receptor, the primary site where opioids exert their effects. Variations in this gene can reduce opioid binding or signaling, making opioids less effective or even ineffective.


• For example, the A118G polymorphism in OPRM1 is associated with reduced opioid sensitivity in some populations.


2. Differences in Metabolism (Cytochrome P450 Enzymes)


• Opioids like codeine, oxycodone, and tramadol are prodrugs that require activation by the liver enzyme CYP2D6 to become their active forms (e.g., morphine from codeine).


• Poor metabolizers (due to genetic variants in CYP2D6) may not convert these drugs effectively, leading to little or no pain relief.


3. Increased Pain Sensitivity (Opioid-Induced Hyperalgesia or Neuropathic Pain)


• Some people experience paradoxical effects, where opioids make pain worse instead of relieving it.


• Neuropathic pain conditions sometimes do not respond well to opioids because they involve nerve damage rather than traditional pain pathways.


4. Tolerance and Receptor Downregulation


• Chronic opioid users may develop tolerance, meaning they need higher doses for the same effect. However, in some cases, receptors become so desensitized that opioids lose their efficacy entirely.


5. Psychological and Neurological Factors


• The perception of pain is influenced by brain chemistry, mood, and expectation. People with high endogenous opioid activity (naturally high endorphins) or certain psychological traits may not feel much effect from opioids.





Would you like me to elaborate on any specific factor?




It might be that you’re the type two kind of person with the problem with metabolizing opioids.

As I understand it o-dsmt is the metabolite of tramadol so it makes sense that taking that you felt something.

But hydrocodone requires breakdown in the liver



Hydrocodone is metabolized by CYP2D6, but unlike codeine and tramadol, it does not fully rely on it for activation. Here’s how it works:


• CYP2D6 converts a portion of hydrocodone into hydromorphone, which is a more potent opioid and contributes to its pain-relieving effects.


• However, hydrocodone itself is already active and binds to opioid receptors, meaning CYP2D6 metabolism is not essential for its effectiveness (unlike codeine, which must be converted into morphine to work).


• CYP3A4 also plays a role, breaking hydrocodone into less active metabolites.





CYP2D6 Variability and Hydrocodone Response


• Poor metabolizers (PMs) of CYP2D6 (those with low or no enzyme activity) may experience weaker pain relief from hydrocodone because they produce less hydromorphone.


• Ultra-rapid metabolizers (UMs) may convert hydrocodone into hydromorphone too quickly, potentially leading to stronger effects or side effects.





So while CYP2D6 contributes to hydrocodone’s potency, it is not required for the drug to work, and its analgesic effect is still present in poor metabolizers, just potentially weaker.



But it seems to me that dilaudid should have worked on you

Dilaudid (hydromorphone) does not require CYP2D6 for activation because it is already in its active form. Unlike codeine, tramadol, or even hydrocodone (which partially depends on CYP2D6 for conversion into a more potent metabolite), hydromorphone works directly at opioid receptors without needing metabolic activation.





How Dilaudid Is Metabolized


• Hydromorphone is mainly metabolized in the liver by glucuronidation (via UGT2B7) into hydromorphone-3-glucuronide, which is inactive.


• CYP enzymes, including CYP2D6, play little to no role in its metabolism.





Implications


• CYP2D6 poor metabolizers (PMs) and ultra-rapid metabolizers (UMs) will generally not experience significant differences in response to hydromorphone.


• Patients who do not respond well to codeine or hydrocodone due to CYP2D6 issues may still get effective pain relief from hydromorphone.






So my best thinking is that you have a problem metabolizing opioids in your liver.

Something like this might be true for you.

If you don’t feel the effects of hydrocodone, several factors could be at play. Here are the most likely reasons:





1. CYP2D6 Poor Metabolism (Reduced Conversion to Hydromorphone)


• Hydrocodone is partially metabolized by CYP2D6 into hydromorphone, which is more potent.


• If you are a CYP2D6 poor metabolizer (PM) (due to genetic variations), your body may not efficiently convert hydrocodone into hydromorphone, leading to reduced pain relief.


• You can get a pharmacogenetic test to check your CYP2D6 status.





2. CYP3A4 Overactivity (Rapid Breakdown of Hydrocodone)


• Hydrocodone is also broken down by CYP3A4 into an inactive metabolite.


• If your CYP3A4 activity is high, hydrocodone might be metabolized too quickly before it has time to work.


• Certain medications (e.g., rifampin, St. John’s Wort) can increase CYP3A4 activity, making hydrocodone less effective.





3. High Opioid Tolerance or Natural Insensitivity


• If you’ve used opioids before, you may have a higher opioid tolerance, requiring a stronger dose.


• Some people have naturally lower opioid sensitivity due to genetic variations in the OPRM1 gene (mu-opioid receptor).





4. Pain Type (Neuropathic Pain or Hyperalgesia)


• Hydrocodone is most effective for nociceptive pain (injury, surgery, inflammation).


• Neuropathic pain (nerve damage, fibromyalgia) often does not respond well to hydrocodone or opioids in general.


• Opioid-induced hyperalgesia (OIH) can paradoxically make pain worse instead of better.





5. Absorption and Other Physiological Factors


• If you have gastrointestinal issues (e.g., gastroparesis), your body might not absorb hydrocodone efficiently.


• Food and pH levels in your stomach can also influence absorption.





What You Can Do


• Try a different opioid: Since hydromorphone (Dilaudid) doesn’t rely on CYP2D6, it may work better for you.


• Consider non-opioid pain management: Depending on the cause of your pain, other medications (e.g., NSAIDs, gabapentinoids, SNRIs) may be more effective.


• Get pharmacogenetic testing: This can determine whether CYP2D6 or other enzymes are affecting your drug metabolism.
Yes, some individuals have genetic or physiological differences that make them less responsive—or even completely unresponsive—to opioids. Several factors can contribute to this:


1. Genetic Variability in Opioid Receptors


• The OPRM1 gene encodes the mu-opioid receptor, the primary site where opioids exert their effects. Variations in this gene can reduce opioid binding or signaling, making opioids less effective or even ineffective.


• For example, the A118G polymorphism in OPRM1 is associated with reduced opioid sensitivity in some populations.


2. Differences in Metabolism (Cytochrome P450 Enzymes)


• Opioids like codeine, oxycodone, and tramadol are prodrugs that require activation by the liver enzyme CYP2D6 to become their active forms (e.g., morphine from codeine).


• Poor metabolizers (due to genetic variants in CYP2D6) may not convert these drugs effectively, leading to little or no pain relief.


3. Increased Pain Sensitivity (Opioid-Induced Hyperalgesia or Neuropathic Pain)


• Some people experience paradoxical effects, where opioids make pain worse instead of relieving it.


• Neuropathic pain conditions sometimes do not respond well to opioids because they involve nerve damage rather than traditional pain pathways.


4. Tolerance and Receptor Downregulation


• Chronic opioid users may develop tolerance, meaning they need higher doses for the same effect. However, in some cases, receptors become so desensitized that opioids lose their efficacy entirely.


5. Psychological and Neurological Factors


• The perception of pain is influenced by brain chemistry, mood, and expectation. People with high endogenous opioid activity (naturally high endorphins) or certain psychological traits may not feel much effect from opioids.





Would you like me to elaborate on any specific factor?




It might be that you’re the type two kind of person with the problem with metabolizing opioids.

As I understand it o-dsmt is the metabolite of tramadol so it makes sense that taking that you felt something.

But hydrocodone requires breakdown in the liver



Hydrocodone is metabolized by CYP2D6, but unlike codeine and tramadol, it does not fully rely on it for activation. Here’s how it works:


• CYP2D6 converts a portion of hydrocodone into hydromorphone, which is a more potent opioid and contributes to its pain-relieving effects.


• However, hydrocodone itself is already active and binds to opioid receptors, meaning CYP2D6 metabolism is not essential for its effectiveness (unlike codeine, which must be converted into morphine to work).


• CYP3A4 also plays a role, breaking hydrocodone into less active metabolites.





CYP2D6 Variability and Hydrocodone Response


• Poor metabolizers (PMs) of CYP2D6 (those with low or no enzyme activity) may experience weaker pain relief from hydrocodone because they produce less hydromorphone.


• Ultra-rapid metabolizers (UMs) may convert hydrocodone into hydromorphone too quickly, potentially leading to stronger effects or side effects.





So while CYP2D6 contributes to hydrocodone’s potency, it is not required for the drug to work, and its analgesic effect is still present in poor metabolizers, just potentially weaker.



But it seems to me that dilaudid should have worked on you

Dilaudid (hydromorphone) does not require CYP2D6 for activation because it is already in its active form. Unlike codeine, tramadol, or even hydrocodone (which partially depends on CYP2D6 for conversion into a more potent metabolite), hydromorphone works directly at opioid receptors without needing metabolic activation.





How Dilaudid Is Metabolized


• Hydromorphone is mainly metabolized in the liver by glucuronidation (via UGT2B7) into hydromorphone-3-glucuronide, which is inactive.


• CYP enzymes, including CYP2D6, play little to no role in its metabolism.





Implications


• CYP2D6 poor metabolizers (PMs) and ultra-rapid metabolizers (UMs) will generally not experience significant differences in response to hydromorphone.


• Patients who do not respond well to codeine or hydrocodone due to CYP2D6 issues may still get effective pain relief from hydromorphone.






So my best thinking is that you have a problem metabolizing opioids in your liver.

Something like this might be true for you.

If you don’t feel the effects of hydrocodone, several factors could be at play. Here are the most likely reasons:





1. CYP2D6 Poor Metabolism (Reduced Conversion to Hydromorphone)


• Hydrocodone is partially metabolized by CYP2D6 into hydromorphone, which is more potent.


• If you are a CYP2D6 poor metabolizer (PM) (due to genetic variations), your body may not efficiently convert hydrocodone into hydromorphone, leading to reduced pain relief.


• You can get a pharmacogenetic test to check your CYP2D6 status.





2. CYP3A4 Overactivity (Rapid Breakdown of Hydrocodone)


• Hydrocodone is also broken down by CYP3A4 into an inactive metabolite.


• If your CYP3A4 activity is high, hydrocodone might be metabolized too quickly before it has time to work.


• Certain medications (e.g., rifampin, St. John’s Wort) can increase CYP3A4 activity, making hydrocodone less effective.





3. High Opioid Tolerance or Natural Insensitivity


• If you’ve used opioids before, you may have a higher opioid tolerance, requiring a stronger dose.


• Some people have naturally lower opioid sensitivity due to genetic variations in the OPRM1 gene (mu-opioid receptor).





4. Pain Type (Neuropathic Pain or Hyperalgesia)


• Hydrocodone is most effective for nociceptive pain (injury, surgery, inflammation).


• Neuropathic pain (nerve damage, fibromyalgia) often does not respond well to hydrocodone or opioids in general.


• Opioid-induced hyperalgesia (OIH) can paradoxically make pain worse instead of better.





5. Absorption and Other Physiological Factors


• If you have gastrointestinal issues (e.g., gastroparesis), your body might not absorb hydrocodone efficiently.


• Food and pH levels in your stomach can also influence absorption.





What You Can Do


• Try a different opioid: Since hydromorphone (Dilaudid) doesn’t rely on CYP2D6, it may work better for you.


• Consider non-opioid pain management: Depending on the cause of your pain, other medications (e.g., NSAIDs, gabapentinoids, SNRIs) may be more effective.


• Get pharmacogenetic testing: This can determine whether CYP2D6 or other enzymes are affecting your drug metabolism.



i used chat gpt to kind of help me with some of the research arriving at the problem metabolizing opioids hypothesis.



i used chat gpt to kind of help me with some of the research arriving at the problem metabolizing opioids hypothesis.

Holy shit brother 😂 thank you for all the info you are a real
 
Any update on this? As someone who's taken hydrocodone for years before I got switched to Percocet, I will tell you everyone is different. I don't think that 45 mgs is enough to OD, even still, I would keep some Narcan on hand. Remember this. The morphine equivalent of hydros to Percocet is 1.5. Meaning that for every 10 mgs of oxy, it is like 15 mgs of hydro. So, when you were taking 20mgs of Percocet, that was like 30 mg of hydro. So you aren't too far off. I hope that helps.
 
I was prescribed hydro 7.5s have 6 left and want to get high.


Here’s the issue, opiods don’t ever seem to work for me? I’m a male, 26, 5’11 185lbs.
I typically do benzos because they always did what I wanted them to, I have done opiods to the extent of:

Prescribed Percocet 5s (up to 20mg dosage)
Prescribed hydrocodone (up to 30mg)
Someone’s grandmas hydros (up to 80mg)
Street Percocet that I believe was real (10s &20s up to 80mg)
ODSMT (unsure of dose)

The only time I felt anything close to euphoria or relaxation was on the ODSMT. I only got nauseous from 80mg oxy. I have never gotten that warm fuzzy feeling. I know I should be thankful to not have the addiction to opiods but I have my battles with other substances.

When I took the prescription Percocet I thought maybe I didn’t get much of an affect since my body had been gettting IV dilaudid for a few days in hospital, (no crazy affects there either besides feeling heavy for a bit)

I wonder if I didn’t feel other substances because I started with too low of doses like 10-20mg oxy several times and developed a tolerance before I reached correct dose.

I haven’t done any drugs recreationally apart form weed in 6 months. And taken 15mg hydro a day for last few days.
How can I assure the best outcome for my planned 45mg hydrocodone dose? And why do you think I don’t ever get that warm fuzzy feeling of wellbeing everyone talks about in opioids?
Hydrocodone is nowhere near as euphoric as oxycodone. For almost 8 years a single 10mg oxycodone ( the good no Tylenol ones which have 11 most instead of 8.9 for the ones with that liver killing Actemetaphane, paracetamol, Tylenol or whatever you want to call that liver killing shit)would actually make me happy and kill pain.
I use it for pain, but up until recently it made me happy. I am still getting mood lifts.
People are sometimes a little shocked that 10mg for over 8 years. I am responsible with opiods and Benzos.
Totally the opposite when I use to drink.
Unfortunately I need more now after on and off for a year( prescribed) then 8+ years steady low dose. Sometimes 2 now. But my fucking state lowered the morphine equivalent guidelines and doctors get arrested all the time. Thank you Obama. I suffer because of the bullshit war on pain patients you started. Then hundreds of thousands died in from fentanyl and now we have
Narcan, Good Samaritan Laws and the opiod deaths hit levels that were unreal.
1. Usually before fentanyl and Narcan availability 5,000+ deaths in America a year from Heroin. 17-18 thousand deaths per year off prescription opiods.
How many were suicides or people getting high?This also before Narcan availability.
This bullshit war is to hide a very expensive flaw in the left wing health care bs.
First in 2000 we spent 1.4 trillion in Healthcare.
By 2023 we nearly tripled that. Thank you Uncle Sam.
Here's the thing about opiods: There is a provision in the Healthcare Laws that the Health Care Companies that are part of the big network of companies; they have to pay for as many trips to rehab as needed as long as people can pay their premiums.

What is the average cost of a 30 day stay? $6,000-$30,000( The six thousand dollar ones are probably dumps)
What is the success rate5%-10%
Can't have too many drug addicts, because they are expensive.

Ah, fentanyl to thin the herd?
Drug addiction costs a lot of money to deal with. Is their a conspiracy?
 
I could never figure it out for myself either. I was on a small regular regiment of 1 to 2 mg of alprazolam a night. Along with 10 to 30 mg of hydrocodone a day.
I'd save up my doses and go into acute withdrawal a few times every other month due to shortages. Sometimes I'd wait a full week only taking the bare minimum one pill a night.

I'd plan out a few days in advance when I got a new amount of pain meds to take a larger amount to get nice and high. I took 4 hydrocodone one afternoon and was only as high as if I took one for a couple hours.

Other times I'd take one or two pills and have extreme euphoria for the majority of the day.
I would experiment with other variables such as amount of sleep, food on my stomach, activity level, other sedatives.

The best results were as follows:

The night before I'd take my normal amount of 1mg alprazolam, 10mg hydrocodone. I'd stay up all night
(simi normal occurrence as if often wake up from not breathing and stay up until the effects subsided).
Take another hydrocodone around noon with another piece of a Xanax.
Proceed to nod in and out due to lack of sleep and the pill combo. Around 3 pm or whenever Id start to feel the effects calm down I would take my last two hydrocodone and go get a steak at a restaurant. I'd be nodding out in the booth and my partner would often have to shake me awake. I'd eat like a champ. Smoke a cigarette, go home and have the best dead fish sex while slipping in and out of consciousness.

That was a normal day off for me back when I used.
People say mixing benzos and opiates is dangerous and I'm sure it is. So purely talking about your ingestion of the hydrocodone, I'd suggest to take with food and lack of sleep.

Also look up the "cold water extraction" for your hydrocodone pills. It's a rudimentary way to filter out some of the Tylenol before you ingest them. You said you had 7.5 and planning on taking 45 mg so thats 6 pills with 325 of Tylenol per pill. 6 times 325 is nearly 2000 mgs of Tylenol all at once.

Now that's not necessary going to kill you or your liver but it's not healthy either. 4000+ mgs of Tylenol is considered the LD , so anything you can do to limit your daily Tylenol intake should be considered.

Be safe , don't be surprised if you have a less than the desired effect. There's lots of variables to consider at play.
 
I was prescribed hydro 7.5s have 6 left and want to get high.


Here’s the issue, opiods don’t ever seem to work for me? I’m a male, 26, 5’11 185lbs.
I typically do benzos because they always did what I wanted them to, I have done opiods to the extent of:

Prescribed Percocet 5s (up to 20mg dosage)
Prescribed hydrocodone (up to 30mg)
Someone’s grandmas hydros (up to 80mg)
Street Percocet that I believe was real (10s &20s up to 80mg)
ODSMT (unsure of dose)

The only time I felt anything close to euphoria or relaxation was on the ODSMT. I only got nauseous from 80mg oxy. I have never gotten that warm fuzzy feeling. I know I should be thankful to not have the addiction to opiods but I have my battles with other substances.

When I took the prescription Percocet I thought maybe I didn’t get much of an affect since my body had been gettting IV dilaudid for a few days in hospital, (no crazy affects there either besides feeling heavy for a bit)

I wonder if I didn’t feel other substances because I started with too low of doses like 10-20mg oxy several times and developed a tolerance before I reached correct dose.

I haven’t done any drugs recreationally apart form weed in 6 months. And taken 15mg hydro a day for last few days.
How can I assure the best outcome for my planned 45mg hydrocodone dose? And why do you think I don’t ever get that warm fuzzy feeling of wellbeing everyone talks about in opioids?
I've been taking them over a decade and I've NEVER got high from them
 
Not everyone finds opioids euphoric or recreational in any manner. I never have. If anything they are frequently dysphoric. I think you’re expecting an effect that just isn’t necessarily going to ever be there.
 
Top