Hydrochlorid form

[Survival0200]

I've figured that if some substances are in hydrochlorid form it means that those substances are water soluble. Am I correct? Well, if that's the case, then I've got an idea.

We all well know that e.g. diazepam isn't water soluble and it's stupid to try prepare Valiums for IV. Anyway, there are diazepam injection liquids that are meant for IV use - so we can figure out that IVing diazepam has some sense.

If we would turn the diazepam in Valium tablets to diazepam hydrochlorid would it make it soluble in water and this way we could IV them?

Anyway, if the process of turning diazepam base to diazepam hydrochlorid would make it water soluble - would that kind of process be hard to perform? Would it be legal?

I'm sorry if I was posting nonsense - I'm just a rookie.

 

[fastandbulbous]

You need a basic function (generally an amine) to allow for the formation of any salt (hydrochloride, sulphate, tartrate etc). None of the functional groups of diazepam are basic enough to form stable salts. You can always go the other route and form sodium salts of drugs containing a carboxylic acid group (eg the barbiturates), but unless you have one of those highly polar groups to form a salt, like THC, you're left with either severe molecular modification (like the N-heterocyclic analogue of THC, which is water soluble in salt form and suitable for injection) or making emulsions for injection (which is a lot more intricate than it seems)

 

[BigBenn]

I suggest you take some chemistry classes. If things like that interest you, those are exactly the things you would learn. I'm glad to see a quest for knowledge.

For some compounds that don't have a basic functional group (like the nitrogen in alkaloids) you can get them to dissolve in water using HPBCD. It is a water soluble sugar that encapsulates non-polar compounds and will dissociate in water. I have used it with steroids but never with benzos.

 

[BilZ0r]

The problem is, that if you made diazepam HCl, when it was dissolved in water, it should turn back into freebase as Diazepam HCl would be a pretty strong acid... (or am I wrong... someone correct me if I am)

 

[jasoncrest]

I've figured that if some substances are in hydrochlorid form it means that those substances are water soluble. Am I correct? Well, if that's the case, then I've got an idea.

We all well know that e.g. diazepam isn't water soluble and it's stupid to try prepare Valiums for IV. Anyway, there are diazepam injection liquids that are meant for IV use - so we can figure out that IVing diazepam has some sense.

If we would turn the diazepam in Valium tablets to diazepam hydrochlorid would it make it soluble in water and this way we could IV them?
D

It's not necessary to convert Diazepam to a hydrochloride salt to shoot it.
You just need to use some solvents in which Diazepam is soluble.

As you know, Diazepam is insoluble in water.

The Diazepam ampoules prepared for injection contain Propylene Glycol and Ethanol (and water), because Diazepam is soluble in Propylene Glycol and Ethanol.

So if IVing pills wasn't dangerous, you could crush the pills in water, add a little bit of Ethanol (pharmaceutical grade 90% ethanol or Everclear) and Propylene Glycol, stir, filter, and shoot...


[It's easy to find Propylene Glycol, there are many OTC medications, which are vials containing a solution, and to be taken as drops. Just find something that is OTC, that contains only water, Propylene Glycol and Ethanol, and an active substance that you can shoot with no problems, and you have your perfect solvent in which Diazepam is soluble...
Again, if pills were not dangerous to shoot, this would be the way to go]