• N&PD Moderators: Skorpio | someguyontheinternet

How to Upregulate a1 GABA Antagonist/ Receptors (and NMDA) - RX Prescription - Benzo Tolerance?

meeoowwmeow

Greenlighter
Joined
Aug 24, 2023
Messages
3
I have included the relevant information of my subject and question to my post up here (below) for those who don’t desire to read my entire lengthy post; which could and would be relevant to your reply anyway. Nonetheless, hopefully, something comes out of this…, This is my first real post - and I'm new; here we go. Nervous it's going to be ignored.

Subject of question:
Being able to take my prescribed daily dose of Klonopin and Xanax preventing tolerance and withdrawal or at least to some degree by interfering/interacting with my (a1 - or others?) GABA and NMDA antagonists/receptors.

How to Upregulate a1 GABA Antagonist/ Receptors (and NMDA) - RX Prescription - Benzo Tolerance?

How may I accomplish this?

If you have any other methods THAT ARE NOT prescription medication for accomplishing my goal, what may those be (herbal/natural)? I am open-minded.

Please ask me anything as well!

______________________________________________________________________________________________________


Please read, I’ve put a lot of time into this; it’s long but I think it's relevant but no pressure. It’s not straight to the point (sorry), I’m just seeking genuine help due to health problems that have been going on since high school - going on 10 years now, anything that you may have to offer that could improve my standard life of living would be greatly appreciated. Sorry for my format, grammar, and punctuation being off or incorrect, I’m just trying to make it an easier read with how I’ve written this.

OK, I HOPE YOUR STILL WITH ME!

I have a multitude of debilitating systemic health issues at my young age that seems to worsen; I am very healthy - well in other regards - explained later. My health issues mostly consist of, respiratory issues, MAJOR CHRONIC sinus issues; with two major surgeries (affect sleep like you wouldn’t believe), digestive issues (severe - plenty of natural fiber- Metamucil can only remotely help - can go days with no bowel movement making me feel sicker), sleep and insomnia, server anxiety and panic with agoraphobia (worsened as my health diminished), major concussions (2 very severe -i had no memory of ANYTHING for hours - name included) with no proper care or treatment following, severe memory issues, autoimmune; and much more - honestly only maybe a few lol. I’ve tried many avenues of treatment and have been open-minded. I’m fairly young and honestly sick of it; no pun intended. I’ve seen way too many doctors for my age…

I have seen plenty of doctors in and out of state who have been “highly regarded” and the standard referrals but always end up inconclusive despite abnormal findings… Or they're pushing a specific drug I declined for valid reasons. I’ve had the run around for years; IMO. I went to UPMC for treatment once and my ‘doctor’ wouldn’t consider treating me unless I got the COVID-19 vax; also very rude and ‘spoke down to me’. With autoimmune problems… I am not taking something SO experimental and man am I glad I ‘carry’ this ‘mindset and knowledge’ (opinion) I have about the current state of our world; horrific, dystopian, Sci-Fi movie-like. Sorry off topic.

Related or not, I was born with a herniated diaphragm, iirc 60-75% intensities in the lungs, a hole in the lung, and a collapsed lung. Doctors thought I had a respiratory infection… one Rainbow Babies Doctor saved my life; Dr. Cramer (spell check - he went military). I also had a birthmark covering my entire stomach basically that was melanoma and had to get it removed; I have two big scars covering my oblique and lower abs. I don’t feel like asking my mother right now for the exacts but it’s pretty on point.

As I mentioned, I am very healthy; I exercise, eat clean, have great support, an amazing SO who takes AMAZING care of me, and so on. Physically (internally?) I am horrific, but I am muscular and in shape.

As I am trying to manage most to all my health problems listed, anxiety, panic, agoraphobia, sleep, and insomnia; these have been a major hit to me this year. I get 2-4 hours of sleep a night on average - with 4 being good. It’s also not consistent sleep, I will wake up, fall back to sleep then wake up and be up for good; cannot get naps in either. With my sinus issues, it’s also impossible to sleep, i cannot describe how thick and big my mucus plugs are and nasal polyps; let alone the thick nasal congestion that’s never-ending. It’s thicker than peanut butter and almost as sticky as THC oil. The inflammation makes it feel like I’m suffocating.

Due to the severe anxiety and panic disorder, agoraphobia, sleep, and insomnia, my doctor has me on 2mg Klonopin daily with 1mg Xanax for panic attacks; and to help with sleep. I have to say I feel my tolerance has shot up fast and the effects are diminished. I haven’t been on them long too as well… Sleep is still bad and 1mg Xanax doesn’t seem to do the trick when needed.

How can I upregulate my a1 GABA and NMDA antagonist/receptors to prevent tolerance and withdrawals? I have attempted to research myself but cannot understand the medical language. I have seen the mention of NMDA; a lot of it I find confusing. A lot of my research that seems ‘cookie cutter’ proven has to do with opiates and I’m not looking for that.

Then Reddit has a million different answers or suggestions that may or may not work. I am unemployed and cannot afford to simply buy and try all of this stuff if you feel me. I understand some may work better than others but I have no idea where the best is to start.

Some of these Reddit posts I’ve read are a few years old or older so has anyone had any success with what I’m trying to accomplish?

Which is: being able to take my daily dose of Klonopin and Xanax preventing tolerance and withdrawal or at least to some degree by interfering with my a1 GABA and NMDA antagonists and receptors.

I hope all my language here is clear enough for you to understand what I’m trying to figure out and accomplish. If I misspoke or was unclear about anything, please comment and I will do my best to explain my misunderstanding.
 
Top