I love threads like this one.
I'm really not sure what I truly have and what is iatrogenic or caused from years of taking various psych meds. I was a bit moody in my pre-teens, partly from a very close sibling's death, partly from just being a bit sensitive and possibly from inattentive ADD as well. It was tough but I think I managed... until about 14.
I was depressed and was very ashamed of admiting it because everyone seemed to think depression=sadness, which it certainly can be with melancholic depression but for me it was just feeling numb. Looking back now I wonder if this was caused from my GP prescribing me imipramine (a very old tricyclic NE and 5-HT reuptake inhibitor with horrible side-effects mostly from its antimuscarinic, alpha1-adrenergic and antihistamine properties) on top of my Dexedrine for ADD and what he thought was depression but looking back was probably just typical teenaged angst. Tricyclics are known to be dysphoric for a lot of people--that and the anxiogenic effects from both of those drugs' inhibition of NE transport, even if it wasn't the cause of the depression and anxiety, certainly didn't help matters.
Perhaps I had been a bit anxious before that, but afterward it was really quite bad. I want to say it was social anxiety but I know some people who have those problems and I'm not sure that's exactly what it was/is. Probably just a lot of embarrassment from being forced into several short-term and one longish-term psych hospitals during my first year of high-school. And then having to return to school the next year trying my damndest to avoid having to explain where I'd been the previous year and always thinking that every one knew and were treating me like I was retarded out of pity... or talking shit behind my back. Neither was probably true but instead I think my friends didn't know any of that and thought that I was being a prick so they seemed to mostly keep their distance. And I mine.
Fast forward to now and my resultingly uneven social skills, periods of self-loathing and perhaps (although this is a new feeling) quite a bit of loneliness. But then I've had some really great times, too. Fell madly in love, met some fantastic people and started to feel like life was worth living. The love ended in heartbreak, the friends moved away, I dropped out of college and moved back in with my parents and while it's sometimes difficult to keep my head above water, I'm starting to feel like everything that happened before will happen again but it's not that bad because for some odd reason I seem to be able to eventually get through it. Maybe it hasn't been the most ideal life but it sure hasn't been boring and with my ADD, that's sometimes all that matters.
A bit of schadenfreude to balance that sappy crap out with some bitterness: most of the people who gave me crap about some of that stuff when I was younger are now on antidepressants themselves.. but probably still as clueless about their own failings as they ever were. I suppose that makes me feel better knowing that these things are quite normal and I may have an advantage later in life by having faced my demons when I did.
I'm taking a lot of Ritalin (too much, probably) these days to focus on classes and not feel overwhelmed by life. I have Xanax for sleep but it's never done anything for my anxiety... just made me feel like an idiot while on it. I've been on multiple antidepressants of every single (FDA-approved) class over the years and, for me, the SSRIs and nearly every other commonly prescribed drug make everything worse.
What has helped a lot, though, are the old MAOIs -- Parnate in particular but Nardil is great for depression with anxiety. People are afraid of the overstated interactions but if you do your research and know exactly what to avoid and what will happen if you don't (in most cases a bad headache and high blood pressure but not a hypertensive crisis or brain hemmorhage unless it's a drug-drug interaction.. but even those are often exaggerated... serotonin syndrome is probably the one thing that isn't).
I tried Lyrica but didn't like the way it made me feel dizzy and it wasn't all that great for my anxiety... or whatever it is. Lamictal, another antiepileptic that has very subtle effects (and few ill-effects if you titrate the dose over a couple of weeks), was almost as good for the depression, etc. as the MAOIs but easier to manage. I think its putative effect is as an antagonist at one of the NMDA receptors so it may be helpful to those who like NMDAr antagonists like ketamine. MXE helped me get through a really rough patch recently but I'm not sure whether the effect will last. What would be nice is to find someone willing to prescribe the partial glutamate and glycine NMDA receptor agonist d-cycloserine. If you don't know about it, it's an old TB antibiotic that has had quite a bit of success with fear-extinction when combined with exposure therapy.