how long after taking Zoloft to Trip LSD

[jakejake678]

hey Bluelight
2 days ago i was prescribed 1 mg klonopin (hell yeah) and 100 mg zoloft's. now i took 100 mg of the zoloft for 2 nights now, when today i forget theirs the STS9 concert, where my buddies are picking up a 10 strip of fire doses. i plan on eating 2. anyway im just wondering, the concert is on friday and im wondering if the SSRI zoloft will interfere and if 3 days off the drug will interfere with the LSD trip. I know you can't mix SSRI's and other drugs such as MDMA or Psicillin. any advice would be nice. thanks!!!

 

[clubberdude]

Well I took 4 strong (apparently) doses of LSD around 12 hours after dosing 50mg of Sertraline and I barely felt a thing, just very minor visual distortions. I believe LSD will be particularly sensitive to the dosing of an SSRI (just a hunch I have - the exclusively serotonergic chemicals being more affected than those with serotonergic and dopaminergic actions), so you'd probably be looking at around 4-5 half lives of Sertraline/LSD dosing gap before the interference between the 2 becomes minimal. Thats around 5-8 day abstinence from using Sertraline (factoring in metabolism etc.). Of course, this is neither safe nor practical in most cases to miss that number of doses - especially if your symptoms are not well controlled. 3 days is probably not going to be long enough. I would imagine in my case (though I do agree everyone is different - a few reports suggest SSRI's don't nullify the effects of LSD that badly, though I believe this is likely idiosyncratic, rather than common), I'd expect at least a 30-40% reduction in effect. You'd feel something, but it may be disappointing.

SSRI's, despite being physically quite subtle in effects, tend to trump the effects of the serotonergic antidepressants (I believe it is because the drug sits on the receptor, blocking the other, psychedelic agent from occupying the receptor), meaning a severe nullification in effect when on SSRI's.