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  • BDD Moderators: Keif’ Richards | negrogesic

Bupe How long after carisoprodol should I wait before taking suboxone?

SuperPsych

Bluelighter
Joined
Apr 29, 2012
Messages
771
I am currently dependent on kratom, somewhere between 20-30gpd I'd say. However, I am much lower than I thought. I have maybe one more dose. I start to experience withdrawal about 4 hours after my last dose.

I've taken 1000mg of Carisoprodal over the last maybe 6 hours or so. I'll probably feel the need to take the suboxone in less than 12 hours. I will probably take a decent amount of gabapentin later to buy more time between my last kratom dose and the suboxone.

I'm worried about the metabolite of Carisoprodal, meprobamate, the half-life of which is 10 hours or so. I'm not certain how much of Carisoprodal is metabolized into meprobamate. I may be being overly cautious but I figured that it's best to ask
 
I am currently dependent on kratom, somewhere between 20-30gpd I'd say. However, I am much lower than I thought. I have maybe one more dose. I start to experience withdrawal about 4 hours after my last dose.

I've taken 1000mg of Carisoprodal over the last maybe 6 hours or so. I'll probably feel the need to take the suboxone in less than 12 hours. I will probably take a decent amount of gabapentin later to buy more time between my last kratom dose and the suboxone.

I'm worried about the metabolite of Carisoprodal, meprobamate, the half-life of which is 10 hours or so. I'm not certain how much of Carisoprodal is metabolized into meprobamate. I may be being overly cautious but I figured that it's best to ask

So you are dependent on kratom and planning to switch to suboxone? Or are you just taking that on and off?
One paper I found seems to have the info you seek. It comes to the conclusion that carisoprodol is indeed active on its own and that meprobamate has indeed a much higher peak plasma concentration of 20.4±1.4 ng/mL while the carisiprodol only has a concentration of 1.53±0.07 ng/mL.

Therefore I indeed would recommend that you wait out 5-7 times the half-life of mep., so 50-70 hours.
 
So you are dependent on kratom and planning to switch to suboxone? Or are you just taking that on and off?
One paper I found seems to have the info you seek. It comes to the conclusion that carisoprodol is indeed active on its own and that meprobamate has indeed a much higher peak plasma concentration of 20.4±1.4 ng/mL while the carisiprodol only has a concentration of 1.53±0.07 ng/mL.

Therefore I indeed would recommend that you wait out 5-7 times the half-life of mep., so 50-70 hours.
I am dependent on Kratom and switching to Suboxone.

I was on Suboxone for 1.5-2 years. Lost my insurance and had to switch back onto kratom which I've been on for a year or so. Finally got my insurance back and am switching back to suboxone.

Well that's a bummer. I have around 5g left of kratom which I'll need before too long. I can probably make it through today with that and plenty of gabapentin. I'll see if I can make it through tomorrow with fistfuls of gabapentin but we'll see.
 
Let me ask you if you got by with kratom - why the need to switch to Suboxone? A kratom taper should generally be more relaxed and shorter than trying to get off subs. At least when measuring your doses. Everyone is different but personally I would prefer maintenance on kratom instead of Suboxone any day. Feels like a step back. Especially if you get by on 5 grams per dose.
 
Let me ask you if you got by with kratom - why the need to switch to Suboxone? A kratom taper should generally be more relaxed and shorter than trying to get off subs. At least when measuring your doses. Everyone is different but personally I would prefer maintenance on kratom instead of Suboxone any day. Feels like a step back. Especially if you get by on 5 grams per dose.
Multiple reasons. With kratom I start to feel withdrawals often after 2 or 3 hours. A 5g dose usually gets me thru every 4 hours okay but there are also lots of times where I experience inter-dose withdrawal symptoms. My sleep also isn't great because I have to wake up at least once a night to dose kratom. Being able to just take one dose a day is nice and suboxone is more discreet. Never liked going to the break room and shoveling spoonfuls of brown powder down my throat.

I've never had luck tapering kratom. I can get down to 15g or so but any less and it really starts to become difficult. My dose always goes back up because at that point even lowering my dose by 500mg is really rough.

My plan is to become stabilized on the lowest dose of suboxone possible and work on a taper with the doctor. I'm also interested in the sublocade shot which I hear is sort of a built in taper with some people doing just one shot and being fine with no need for a second.

And most importantly, I am recently out of a job and can't afford kratom. Insurance should cover my suboxone so it's either suboxone or withdrawal. I've attempted a kratom cold turkey twice in the last year. Made it to 6 days or so both times and broke because the pain was just as bad on day 6 as it was on days 2-3. I'm In the process of looking for another job (which I need ASAP) and can't really afford to be laid up in withdrawal for a week, especially with interviews and everything.

So a lot of factors went into it. Main driving factor is the finances, 2nd being the stability
 
Wow seems you have it really bad. Makes sense for sure. Good luck with your plan.
I've survived much worse. I've just been on either kratom or suboxone ever since the beginning of the Covid pandemic so it's pretty difficult to come off of at this point. I appreciate the kind words
 
In general, Carisoprodol (Soma) and its active metabolite Meprobamate (Miltown) are considered to be on the more dangerous side when taken in combination with Opioids. It's hard to say objectively without data in front of me, though my understanding has always been that Meprobamate is very similar to a short-acting Barbiturate in terms of its effects and its potential for causing overdose. Confusingly, there is a class of pharmaceuticals known as "non-Barbiturates". This class contains pharmaceuticals that mimic the effects of Barbiturates in almost every way, while being distinct from Barbiturates in terms of their chemical composition. Another example of a "non-Barbiturate" drug would be Methaqualone (Quaalude), a drug also known for being dangerous in combination with other CNS depressants.

1,000mg Carisoprodol isn't an insanely high dosage. So long as that is all that you're going to take and you're also waiting several more hours before taking the Buprenorphine, I doubt you would be in any danger here. The worst case scenario would be heavy sedation provided you don't throw anything else into the mix.
 
I appreciate the thorough reply. Can always count on you Keif'. I figured I'd probably be fine. It's been almost 12 hours since my First 500mg of carisoprodol. The other 500mg was taken in chunks over the next few hours. Oh yeah, I did also through up shortly after my first 2 doses. Soma has never made me vomit before but I was also on allylescaline and ate too many spicy chips.

I hate to do this but I have a friend who may help me get an ounce of kratom tomorrow. That'll buy me one more day or so before needing to start suboxone, in which case I'm certain that I'll be safe. I have read posts of people taking Xanax with bupe and also soma at the same time and being fine, but I also don't have the tolerance to suboxone anymore so I am expecting some respiratory depression when initiating the subs.

Thanks again for the help, that was very informative 👍
 
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