aced126
Bluelighter
- Joined
- May 18, 2015
- Messages
- 1,047
Apparently if you take phenobarbital and warfarin together (both metabolised by 2C19), the warfarin loses its effectiveness because it gets metabolised by the enzyme more.
I would've thought the phenobarbital would act as an inhibitor of 2C19 (as well as the warfarin acting as an inhibitor) and that both drugs would potentiate one another. Apparently this is not the case; can anyone explain this in more depth?
I would've thought the phenobarbital would act as an inhibitor of 2C19 (as well as the warfarin acting as an inhibitor) and that both drugs would potentiate one another. Apparently this is not the case; can anyone explain this in more depth?