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How did you personally become knowledgeable about drugs?

Rio Fantastic

Bluelighter
Joined
Feb 19, 2009
Messages
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Location
Birmingham
Hello,

This especially applies to anyone who's knowledge about drugs is entirely self taught and not derived primarily from university educations, but I'd love answers from anyone. How did you become so knowledgeable about drugs? What was the most important subject to learn - chemistry, pharmacology, neuroscience, or some mix of all of them? Are there any websites or books you can point me to to get a good foundation to start building up my knowledge? I know the basics but only know enough to vaguely be able to follow the threads in this forum, I'm nowhere near good enough to be able to extrapolate drug effects from molecular structure, a skill I'm extremely envious of. I'd really love any answers at all :)
 
That's a good question, I'd like to hear answers from other people as well.

As for me, my overall knowledge about drugs is limited to knowing what receptors some drugs affect, in what way and what that means. I haven't good SAR knowledge or in-depth pharmacological understanding of many things. I'm university-educated in chemistry, but the rest of my knowledge comes from hobby-reading Wikipedia, science journals/articles in my free time. So for me the most important subject to have learned is definitely chemistry, because pharmacology is mostly chemistry after all. Besides, I find that the understanding of chemistry provides not only knowledge in that field but a more general understanding of the material world and also the ability to think logically in that context, which helps here and elsewhere too.

I understand that my point of view is most certainly biased (everyone loves their own field, right?), but I'd say the most solid base for pharmacology and understanding drugs is chemistry, because pharmacology relies on chemistry. I can't recommend any particular books, but I think you could start with something like "basics of organic chemistry" and "basics of pharmacology/biology" and work your way up from there. University education would certainly help a lot, but if that's not an option for you, then I'm certain you can educate yourself through books and this forum to a reasonable degree. Scientific articles are also good for bedtime reading. Remember that thinking and asking questions is very important!
 
I don't know about chemistry and molecular , but everything I know about drugs I have learnt from Google or light , it would be interesting to read some books on how which drugs affect which receptors :)
 
I have a history of mental problems where genetics might have contributed (mother severely suffering, one half-brother father wise committed suicide at an early age due to unknown reasons - explosive mixture) as well as other factors. So I ran into our far-from-optimal psychiatric care system while knowing nothing at all about pharmacology or drugs, didn't even drink harder alcohol back then ... they tried various prescription meds on me which had profound effects but were mostly rather bad than good. Also as it seems to be unavoidable in such therapy settings, I've heard people talk about drugs and the effects they have. Being naturally curious and interested in how things work etc. I quickly became interested in these topics. It finally got me when I've tried DXM and experienced such an indescribable relief from that life-long depression (besides the usual trippy effects).

But as these topics aren't that liked to see in the general public, good information is rare and I had nobody to talk about with (this is still the case these days), well.. I made some of the usual mistakes. But with the internet all that exciting information is available to everyone interested in it - okay, if we forget about all this abstract-only paywall shit for now - I've managed to educate myself to some degree over the time.. which tends to make doctor consultations somewhat exhausting, as they usually don't like to get confronted with semi-educated self-taught hobby neuroscientists that have complicated disorders too.

On the other side, it got me around some really nasty things that could well have turned me really down (e.g. my strange adverse reactions to strong dopamine antagonists, aka neuroleptics), if I had just blindly trusted the professionals as usual.. and it's a truly interesting and intriguing matter after all.

Learning the basics of chemistry and biology in evening high school (how do you call that? where adults can catch up their graduation) has filled many gaps but I finally need to read though more advanced textbooks.. and I would love to be allowed to university, be it for a related subject or something new.. but I'll have to do 2 more years of high school before that, and then I'll have a hard time to get a place at all and pharmacology / chemistry / etc will be out of question due to criminal record (fuckin' legislation).

I truly think and believe that responsible and knowledge-/science-based drug use, therapeutical as well as recreational, is a very real possibility and it's much more about the circumstances, social environment, learning, educating, reflecting ... than 'the substances being dangerous' or 'too powerful' or 'bad', whatever prohibition shit.
Having said that, I've never been into any 'drug scene' or anything, I've always been the more or less lone researcher ... and while I made numerous mistakes too, I truly can't believe how incredibly reckless so many people / users act, some having varying degrees of knowledge but very few seem to know about the actual science or are even interested in it.. also I really hate being 'wasted' or 'fucked up'- what does a black out give me, really? This is something I don't understand. Altered states can be exciting and intriguing of course, but there are such and such ones ...
 
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I'm nowhere near good enough to be able to extrapolate drug effects from molecular structure, a skill I'm extremely envious of.

I was pretty much in your position like 6 months ago. Getting a good understanding of organic chemistry and simple molecular biology (the former being way more important though imo) is crucial.

If you want to predict effects from structures, all you need to do is: identify what set of compounds this belongs to/ what pharmacophore is present in this compound. I'll give an example. Look at the basic structure of amphetamine:
1-phenyl-2-aminopropane.png


This skeleton is the basic structure which most dopamine releasing stimulants follow. There needs to be a phenyl ring and a nitrogen spaced about 2 carbons away from the ring. If you identify this skeleton in a molecule then there'd be a good chance that it'll have psychostimulant properties. E.g:
1-phenyl-2-methylaminopropane.png

1-phenyl-2-ethylaminopropane.png

1-phenyl-2-methylaminobutane.png


The reason why all these compounds release dopamine is more of a biological question, but to be brief, all these compounds bind to the dopamine transporter (that's why they all have to have the basic properties common to all of them - phenyl ring and nitrogen), get transported into the neuron, release dopamine from vesicles and make the transporter work in reverse and pump dopamine into the synaptic cleft. The electrical impulse is then passed on to the next neuron by the pumped out dopamine.

The next thing to observe about this set of compounds is that substituted atoms on the ring of the molecule lead to release of serotonin.
1-(4-fluorophenyl)-2-methylaminopropane.png

1-(4-chlorophenyl)-2-methylaminopropane.png

1-(1%2C3-benzodioxol-5-yl)-2-aminopropane.png


And so on. Basically looking at loads of structures of a set of compouds will eventually make you understand what will work and what won't for a compound to have the effects of that set.
 
I have a history of mental problems where genetics might have contributed (mother severely suffering, one half-brother father wise committed suicide at an early age due to unknown reasons - explosive mixture) as well as other factors. So I ran into our far-from-optimal psychiatric care system while knowing nothing at all about pharmacology or drugs, didn't even drink harder alcohol back then ... they tried various prescription meds on me which had profound effects but were mostly rather bad than good. Also as it seems to be unavoidable in such therapy settings, I've heard people talk about drugs and the effects they have. Being naturally curious and interested in how things work etc. I quickly became interested in these topics. It finally got me when I've tried DXM and experienced such an indescribable relief from that life-long depression (besides the usual trippy effects)

First of all, thank you very much for your detailed and intelligent response. I must say, I have been very surprised by the similarities in our personal stories. One key difference is that my interest in drugs predates the development of my own mental health problems - ever since I was twelve and got a grasp on what drugs actually were, even the very idea of them appealed to my natural curiosity and thrill-seeking tendencies, and this desire for experimentation thankfully came years before I had the resources or the like-minded social circle to begin my forary into experimentation with my consciousness. However, like you, I too developed mental health problems, although later than you - the mild symptoms began when I was 18 but my first full-blown episode didn't occur until I was 19 where I was diagnosed as Bipolar when I was was committed to a psychiatrist institution. If you don't mind me asking, although you weren't specific I'm guessing that you suffer from dysthymia or perhaps unipolar clinical depression? I too also have had primarily negative experiences with prescribed psychiatric medication - some just an unhelpful annoyance at best, and some completely awful;. Like you, the interest in psychiatrist medication that any sensible person would cultivate upon development of a mental illness was compounded by my interest in all psychoactive substances, until it bloomed from an interest into a total passion.

But as these topics aren't that liked to see in the general public, good information is rare and I had nobody to talk about with (this is still the case these days), well.. I made some of the usual mistakes. But with the internet all that exciting information is available to everyone interested in it - okay, if we forget about all this abstract-only paywall shit for now - I've managed to educate myself to some degree over the time.. which tends to make doctor consultations somewhat exhausting, as they usually don't like to get confronted with semi-educated self-taught hobby neuroscientists that have complicated disorders too.

On the other side, it got me around some really nasty things that could well have turned me really down (e.g. my strange adverse reactions to strong dopamine antagonists, aka neuroleptics), if I had just blindly trusted the professionals as usual.. and it's a truly interesting and intriguing matter after all.

Hahaha, this certainly hits home. No, in my experience they certainly are not too fond of patients who don't shut up and take what they're told to take. I don't know if I've just had bad luck with psychiatrists or if it's something about the profession - perhaps being made to deal with un co-operative patients who aren't in their right mind means that they naturally develop a lesser regard for a patient's own sense of agency and dealing with paranoia/lack of insight fosters their "I always know best" mentality.

I have had several debates with psychiatrists, one of the most recent ones that sticks in my mind is having a psychiatrist insist to me that neuroleptics cannot cause a dysphoric reaction, and the intensely negative, hopeless and depressed feeling of malaise that hits me every time I took the fucking poisonous shit was all in my mind. All it takes is a quick google search or even reading the leaflet that comes with the damn tablets to find out that what he was saying was patently untrue, but I digress. I think I am particularly sensitive to anti-psychotics as well, and I lost faith in the psychiatric system when I was locked in an institution for an entire Summer and despite the manic episode burning itself out a month or so in, being kept in there for a further two and a half months solely on the basis of my refusal to take neuroleptics ON TOP OF a mood stabilize with the justification being that my refusal to take them showed a "lack of insight", culminating in me being forcibly given a long-lasting depot injection against my will and all of this despite me taking the Depakote as prescribed and the fact that my manic episode had long ended. There are very few neuroleptics I haven't tried, and with varying degrees of severity they all do the same thing to me - leave me feeling permanently tired, sleeping 12-14 hours a day, feeling totally apathetic/numb at best and depressed & dysphoric at worst, draining all the personality and life out of me, anhedonia ranging from incredibly frustrating to so total as to make me feel suicidal with the bleak misery it inflicts on me and a slowing of my mind to the point of always feeling like a zombie. Horrible shit. When I was forced on haloperidol during my time in there, I even had severe and painful dystonia, where my neck and shoulder muscles would keep locking, and it mounted in severity to the point of total agony whilst I begged the nurses to help me when it became too painful to bear, and they ignored me for forty minutes, thinking that I was lying/exaggerating, so indeed, I share your distrust of the psychiatric system and your dislike of neuroleptics. Out of curiosity, what is it antipsychotics did to you that you found intolerable?

Learning the basics of chemistry and biology in evening high school (how do you call that? where adults can catch up their graduation) has filled many gaps but I finally need to read though more advanced textbooks.. and I would love to be allowed to university, be it for a related subject or something new.. but I'll have to do 2 more years of high school before that, and then I'll have a hard time to get a place at all and pharmacology / chemistry / etc will be out of question due to criminal record (fuckin' legislation).

Ahh, I see. Indeed, the consensus does appear to be that I need a good foundation in organic chemistry as my best bet to become more knowledgeable about psychopharmacology. By the by, I do plan on going to university myself, and am taking an Access to HE course next year as a kind of fast track towards that, but in the meanwhile want to do the same as you've done and teach myself as much as possible. The science in being able to understand the nuances of drug design and being able to have a reasonable idea of how a drug will work from looking at its structure is something that fascinates me, and it appears this somewhat specialist knowledge lies at the intersection of several subjects, but I feel like the answers in this thread have simplified the path ahead of me somewhat now. By the way, if you live in Europe or the UK, is there no chance your conviction will ever become spent? Here in the UK at least, most minor offences become spent and no longer have to be declared unless the institute you're applying for does a special, enhanced check, of which only a few institutions are authorized to do so, which are mainly just schools and groups working with vulnerable adults etc. A minor conviction should not prevent you from getting work in the field of chemistry or pharmacology, especially if it's something like simple possession. If you've been caught drug dealing or have a violent offence that will always be on your record, it might be a different story.

I truly think and believe that responsible and knowledge-/science-based drug use, therapeutical as well as recreational, is a very real possibility and it's much more about the circumstances, social environment, learning, educating, reflecting ... than 'the substances being dangerous' or 'too powerful' or 'bad', whatever prohibition shit.

Having said that, I've never been into any 'drug scene' or anything, I've always been the more or less lone researcher ... and while I made numerous mistakes too, I truly can't believe how incredibly reckless so many people / users act, some having varying degrees of knowledge but very few seem to know about the actual science or are even interested in it.. also I really hate being 'wasted' or 'fucked up'- what does a black out give me, really? This is something I don't understand. Altered states can be exciting and intriguing of course, but there are such and such ones ...

I totally agree with you here. It would take an enormous cultural change, and though it sometimes feels like one step forward and two steps back, I think there are positive signs, the legalization of cannabis that is sweeping through the USA being a HUGE step in the right direction. I think that all drugs should be legal on principle, and have never heard a compelling argument to the contrary. And yeah, many people are irresponsible with drugs, and though I think for as long as there are drugs there will be idiots misusing drugs, I think the statistics of deaths and injuries could drop vastly if in the context of legalization there was widespread education to try and dispel all the misinformation that surrounds drug use. And indeed, the amount of people who love to take drugs and will consume any pill, powder, drink or smoke offered to them but have zero interest in what it's actually doing in their body when it's inside. However, I think as the information becomes more easily accessible, there will hopefully be more and more educated and intelligent drug users. I also suspect that there may be more educated, intelligent drug users interested in the science behind drugs than there may appear - they may not mix with other users as much and may be forced to keep it somewhat hidden, and would have more to lose if the information did come out, whereas compared to the idiots who mix with other idiots and end up in the headlines for killing or injuring themselves doing idiotic things, the intelligent ones go through life unnoticed if that's what they choose. Also, as far as I can tell the quest to get as wasted/fucked up as possible & the pursuit of total oblivion is usually people looking for a complete escape from their lives, usually rooted in deep seated depression or discontent.

Didn't realize till I looked back this is an awfully long post! I'd love to hear your answers to the questions I posed but I realize it is very very long, so I'll understand if I don't get a response or not a timely one, but I hope I get one, you seem very intriguing and I feel like we hold similar viewpoints on quite a few topics. Thanks again for your reply :)
 
I was pretty much in your position like 6 months ago. Getting a good understanding of organic chemistry and simple molecular biology (the former being way more important though imo) is crucial.

If you want to predict effects from structures, all you need to do is: identify what set of compounds this belongs to/ what pharmacophore is present in this compound. I'll give an example. Look at the basic structure of amphetamine:
1-phenyl-2-aminopropane.png


This skeleton is the basic structure which most dopamine releasing stimulants follow. There needs to be a phenyl ring and a nitrogen spaced about 2 carbons away from the ring. If you identify this skeleton in a molecule then there'd be a good chance that it'll have psychostimulant properties. E.g:
1-phenyl-2-methylaminopropane.png

1-phenyl-2-ethylaminopropane.png

1-phenyl-2-methylaminobutane.png


The reason why all these compounds release dopamine is more of a biological question, but to be brief, all these compounds bind to the dopamine transporter (that's why they all have to have the basic properties common to all of them - phenyl ring and nitrogen), get transported into the neuron, release dopamine from vesicles and make the transporter work in reverse and pump dopamine into the synaptic cleft. The electrical impulse is then passed on to the next neuron by the pumped out dopamine.

The next thing to observe about this set of compounds is that substituted atoms on the ring of the molecule lead to release of serotonin.
1-(4-fluorophenyl)-2-methylaminopropane.png

1-(4-chlorophenyl)-2-methylaminopropane.png

1-(1%2C3-benzodioxol-5-yl)-2-aminopropane.png


And so on. Basically looking at loads of structures of a set of compouds will eventually make you understand what will work and what won't for a compound to have the effects of that set.


Thank you for breaking down the analysis of the molecular structure to give me a basic idea of how its done. You've demystified the process for me somewhat, although I'd need a lot more studying, research and practice in order to get a solid grasp of it like you've obtained. What books or websites did you use to build up a solid chemistry foundation? Also, this is going a little off topic here, but if dopamine releasing agents all conform to roughly the same pattern, and it's tiny variations in this structure that can make or break a decent stimulant - i.e. the difference between pseudo-ephedrine and methamphetamine - is it not feasible that at some point the perfect dopamine releasing agent will be discovered, which is the absolutely ideal fit for the receptor and bonds the strongest to it, that will release the maximum amount of dopamine possible and after which no stimulant based around the same structure will be able to better it, because the ideal "key" for that receptor has been found, so to speak? I'm pretty tired at the moment so I hope I'm making sense here.
 
Bluelight (haha), erowid, and my own personal experience.. also did a lot of research on said "drugs" and their effects on the human brain..interesting stuff.
 
The theoretical knowledge I gained from reading, both on the internet and from some textbooks.

The "practical knowledge" (like, for example, softly exhaling on a piece of hard tar heroin to soften it up with the moisture of your breath & make it easier to divide without pieces flying everywhere) I learned from drug addicts.
 
I am a gardener and into horticulture. That is my specialty I guess. I grew mushrooms, and marijuana, as well as a san pedro cactus. I learned everything from older growers, books, and online sources. I don't know much about chemistry...but I know a lot about creating the right conditions to produce very strong plant based drugs. I have yet to grow opium poppies but I am reticent to do so because I had a very bad opiate problem for a while.
 
I am a gardener and into horticulture. That is my specialty I guess. I grew mushrooms, and marijuana, as well as a san pedro cactus. I learned everything from older growers, books, and online sources. I don't know much about chemistry...but I know a lot about creating the right conditions to produce very strong plant based drugs. I have yet to grow opium poppies but I am reticent to do so because I had a very bad opiate problem for a while.

Have you given trying to grow kratom any more thought?
 
Thank you for breaking down the analysis of the molecular structure to give me a basic idea of how its done. You've demystified the process for me somewhat, although I'd need a lot more studying, research and practice in order to get a solid grasp of it like you've obtained. What books or websites did you use to build up a solid chemistry foundation? Also, this is going a little off topic here, but if dopamine releasing agents all conform to roughly the same pattern, and it's tiny variations in this structure that can make or break a decent stimulant - i.e. the difference between pseudo-ephedrine and methamphetamine - is it not feasible that at some point the perfect dopamine releasing agent will be discovered, which is the absolutely ideal fit for the receptor and bonds the strongest to it, that will release the maximum amount of dopamine possible and after which no stimulant based around the same structure will be able to better it, because the ideal "key" for that receptor has been found, so to speak? I'm pretty tired at the moment so I hope I'm making sense here.

I don't really have a solid chemistry foundation, I'm still learning. If you studied chemistry in school then Organic Chemistry by Clayden is good. If not then you might need to read a more basic book first and then that book. As for the other question, yeah certainly agents that bind better to the dopamine transporter are possible and yet to be found. For a compound to release dopamine it needs to unbind from the transporter once inside the cell though. Compounds which either don't unbind from the transporter or prevent it from flipping into the cell will act as reuptake inhibitors instead (like methylphenidate). If a compound permanently and irreversibly binds to a receptor (e.g if it forms a covalent bond to it), the receptor will after some time fall back into the cell and get recycled.

For your specific example, there is another factor effecting the relative stimulant properties of the said compounds. For a compound to be active in the brain it needs to bind to its target/receptor properly and it needs to cross into the brain effectively. The brain is guarded by the blood-brain barrier which only allows fat-soluble compounds to pass through it (it has some transporters for specific compounds like amino acids). Methamphetamine is much more fat soluble than pseudoephedrine because it doesn't have that hydroxyl group on the beta carbon. The hydroxyl group can form hydrogen bonds to surrounding water molecules meaning more of it would stay solvated by water rather than cross the BBB. If pseudoephedrine was injected directly into the brain I'd say it would compare similarly to methamphetamine in dopamine releasing properties.
 
Have you given trying to grow kratom any more thought?

actually yes I have. I have been researching exactly what they need. Kratom is especially fickle when it comes to soil and lighting conditions...not to mention I am going to have to find a way to raise the temperature but also allow more light during winter months in florida. I also have to replicate monsoon season. I am thinking maybe a Hot House type setup that pours a deluge of water for a predetermined amount of time daily. Also, I have read that it takes a long time for a tree to develop any significant amount of alkaloids in it. I worked at a vineyard in new york....I learned about grafting trees on to roots, which I think is going to be what is needed. Maybe find a similar type of tree, and graft the new plants onto it. Same way we grow apples in the states. Start off by growing a crab apple tree (which grows well here) chopping it down and putting a slit in the stump, and using a compound to join a better tasting fruit bearing tree to it.
 
actually yes I have. I have been researching exactly what they need. Kratom is especially fickle when it comes to soil and lighting conditions...not to mention I am going to have to find a way to raise the temperature but also allow more light during winter months in florida. I also have to replicate monsoon season. I am thinking maybe a Hot House type setup that pours a deluge of water for a predetermined amount of time daily. Also, I have read that it takes a long time for a tree to develop any significant amount of alkaloids in it. I worked at a vineyard in new york....I learned about grafting trees on to roots, which I think is going to be what is needed. Maybe find a similar type of tree, and graft the new plants onto it. Same way we grow apples in the states. Start off by growing a crab apple tree (which grows well here) chopping it down and putting a slit in the stump, and using a compound to join a better tasting fruit bearing tree to it.

Hmm, actually seems quite complicated, but thrilling nonetheless. Good luck if you do attempt it and definitely do post some results! Sometimes I wish I was a gardener or knew how to grow plants. But well I guess I'll stick to growing molecules in a glass pot. I digress...
 
My family are all addicts so I was prone to research from a young age.
Silly me thought I could help them by trying to understand.

So I went with a few short stints in formal chemistry education but mostly just reading scientific journals & looking for hardcovers/ebooks.
Hope to speciaiize as proces-operator (petrochemistry)
Might aswell utilize this knowledge into something that makes me money...
 
Rio Fantastic, thanks for your detailed & intelligent response too, nice to read from you :)! This is exactly why I write here on bluelight and especially on NSPD. I know I can't always hold the standards as we are all humans & I'm still learning every day, but this here is the only place where one can talk about the matter (neuroscience, whatever) on par without all these trolls flooding in ;)

Indeed I have been somewhat fascinated by dreams at a very early age and having been a technic geek back then, this ultimately lead to the thought of altering one's consciousness with exogenous things / finding ways to escape reality and enter dreamscapes or virtual worlds in my brain, but I knew just nothing about the matter (luckily, maybe). I've been fascinated too by the idea of nano bots for example, being able to repair cells from inside the blood stream, as well as improving our bodies etc.. At first I felt somewhat disenchanted when I realized that most drugs are just about getting fucked up etc.. but as you say, this is just the part that unfortunately is most public. What comes most close to my initial 'dream drug' probably really are the dissociatives.. well, my drugs of choice. But they have numerous other benefits I would never have thought of ...

(As a side note, I could mention now that I fantasized about things like some VR technology like the now-real Ocular Rift as well as a community network like Facebook - I've called it CommuniCity back in 1997 or so - years before these went public.. there are a few people who probably remember these ideas, and I think many other people will have had similar ideas but just not the right connections at the right time to push them through... this might sound delusional or whatever, but it is true!)

I'm somewhat tired now but I'll answer you fully tomorrow or so!

manboychef, did you already try to cultivate erythroxylum novogranatense or other related species? There are many - completely legal - phenyltropanes one could more or less easily synthesize out these leaves ... of course, just plain leaf tea would be interesting too, but the legality thing about the derivates somewhat intrigues me! Enough motivated people could possibly lead to a breakdown of these ugly organized structures in mid-south America..

But this is just the very first thought of course. Give me some time and I'll come up with some much more fascinating, completely legal species that I would love to see them grow and having the biosynthesized molecules available for those interested in them then... ;)
 
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Reading Shulgin's PIHKAL was a big education for me; it didn't make me an expert, but I started to understand what he called the "music" of the chemistry and pharmacology.
 
@dopamimetic...if I could find a place to grow a decent sized crop I would do so...I believe what I read there is that they keep producing leaves, so if you can keep the plants alive they will continue to grow constantly regardless of dry season or wet season....and that cocaine content is amazing...the coca varieties they grow in some parts of south america don't even contain that high a percentage. It would be a cool experiment. I bet if I could get some property I could grow them. The only problem is I would have to use seeds to propagate them because they don't do well as cuttings. I doubt rooting compound would even work on them.
 
I went to pharmacy school so had formal education on all things related to drugs. But when I think about why I went, I go back to my childhood. Whenever I was sick or had a headache or whatever, I always remember asking my mom if such and such is safe (I was a kid so thought mom knew best) and was always fascinated how a little pill can have such a huge effect.

I got to admit, BL has been very instrumental recently for me in my continued learning. A few years ago, I had a bit of a personal crisis and doubted very strongly that I wanted to continue being a pharmacist. When I joined here, the breadth of information triggered that fascination again and I study and read more about drugs than ever before. It is wonderful how there are both professionals (chemists, pharmacologists, doctors etc.) as well as experienced users lacking formal education relaying the info they know here.

I always thought Lippincots was a good concise series of books to start learning from. They arent too in depth so you will eventually need to find better sources, but easy for even a layman to follow.
 
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