Holy Trinity (lsd, mushrooms, mescaline)

[psood0nym]

I suppose you would have to know the binding affinity data for each of the active compounds to know which compound would displace the others at any one particular receptor site, and then account for what other site the displaced compound is then likely to bind to. That is, if you're going in with the idea of "filling in the gaps" in the 5HT receptor profile by taking all the heavy hitters. The whole idea that we can use affinity and efficacy data to write recipes for making the perfect receptor profile cocktail strikes me as a bit brash in its reductionism. Doctors are now often advised NOT to give fMRIs of the lower back because their misinterpretations of complex and ambiguous features of the readings too often results in deleterious over treatment of patients. The lower back is too complicated for physicians to make sense of with fMRIs, and we're talking about trying to use binding data to back up a theory that predicts radical subjective states?

In my opinion, the only semi-reliable predictor of good psychedelic combos we have is user reports. You just have to try it. I don't see any reason to believe that combining LSD, psilocin, and mescaline would result in anything particularly special. But it might. Try it, and let us know.

 

[greenmeanies]

On my last car ride I brought three friends.
Alice, Pedro, and Max.
I've known alice for ONE year, pedro for about 650 days, and Max for 5 years, dig?

The first time I hung out with Alice we just hung out for 1 minute. We are good friends and have hung out as many as 6 minutes at once.
The first time I hung out with Pedro we hung out for 750 minutes. This is the longest we have ever hung out.
The first time I hung out with Max we hung out for 1.75 minutes. We are good friends, and have hung out for as many as 7 minutes at once, on a few occasions.

The reason we don't SWIM here is because it makes it difficult to decipher what exactly were the doses and times used in the experience.

Am I correct in my interpretation: You combined 1 tab of LSD, 650mg of Mescaline, and 5 grams of mushrooms on this particular journey?

And in the past you have had experiences with up to 6 tabs of LSD, or up to 750mg of mescaline, or up to 7 grams of mushrooms?

 

[IamMe90]

Ismene is correct. After much experimentation, I've concluded that it seems more or less pointless to combine multiple 5-HT psychedelic drugs in order to attempt to achieve a significantly novel or synergistic high. A far more interesting and useful combination of psychedelic drugs would be one that spans multiple receptor types, such as 5-HT, NMDA, k-opioid. (Like DMT, Ketamine, Salvia.)

I disagree that combining multiple 5ht psychedelics is pointless. Some combinations seem moot but I have a lot of experience with plenty that seem so synergistic to the point where the combo is like its own drug. 2c-x + LSD (especially 2c-e and 2c-i), 25i + LSD, mescaline + LSD are just examples. 2c-e + LSD and 25i + LSD in particular were some of the most jaw dropping experiences of my life, going far beyond what each drug could do individually.

 

[greenmeanies]

^indeed. Some people feel that it's best to combine drugs that are very similar (2C-E and 2C-I) to get a more "rounded trip" that exceeds either one on its own.

Others feel that two very different drugs (2C-E and 4-AcO-DMT) help give a totally new experience.

I will agree that psychedelic+empathogen is a very special combo class of its own, as well as psychedelic+dissociative.

But this thread is mainly about different psychedelics, specifically the "big three classics" that are relatively safe and well established in terms of dose and effects. It would be far more dangerous to suggest that people start combining various amounts of new and potent research compounds, especially if they have not yet established their own safe dose for the drugs individually.

 

[dragonstripe]

The reason we don't SWIM here is because it makes it difficult to decipher what exactly were the doses and times used in the experience.

Am I correct in my interpretation: You combined 1 tab of LSD, 650mg of Mescaline, and 5 grams of mushrooms on this particular journey?

And in the past you have had experiences with up to 6 tabs of LSD, or up to 750mg of mescaline, or up to 7 grams of mushrooms?

You have correctly interpreted what I said.

Here are some details so you can imagine some of the mindset:

5g psilocybe cubensis dry
500mg vial + 250g of peruvian torch = 650mg of mescaline
1 tab (100-150ug) dropped from "Owsley's last batch" on double-sided Ganesha print/Alex Grey print blotter. I ate the eyes.

Previously:
The first time i ever dosed anything was around 600mg of mescaline. I thought the police were coming after me for having a vial of mescaline in my pocket. I ended up in my friends closet when she wasn't even home, calling her frantically. Then the anxiety and fear subsided and I had a great time, I saw the sky open and turn into heaven. This opened my mind to more trips.
I have taken 2 mescaline vials before (so thats 800-900mg depending on how liberal the lab was) but it was not on an empty stomach, so i say 750g.

Mushrooms:
I have taken various quantities - 1.75g, 3.5g, 5g, 7g. When i take mushrooms, i lock myself in my room, alone.

Acid:
1 tab, 2 tabs, 3 tabs, 6 tabs (3 double+ dosed tabs, unknowingly)
The double dose trip was the worst fucking thing ive ever been through. Firstly, i was pooping as i came up, all of a sudden the rust in the bathroom started attacking me, my poop turned orange, i threw up liquid, then clowns with chainsaws started disemboweling me. I eventually got out of that and made it to my room, where my girlfriend came and I told her i loved her, she didnt believe me, got mad at me for tripping so much, and left. My friends came to my room and tried to talk to me, but i was hallucinating too strongly. Here's what happened:
I "woke up", my friend offered me a beer. He said, today you're going to die, buddy, im sorry. You broke your brain with too much acid and now the consciousness police have to kill you so you can be reincarnated and have a new brain. This was to happen when i went outside. This scenario happened over and over with every one of my friends, until i said "no. i dont want to." That's when i hallucinated that i was going to prison.

Because i didnt want to die, i had to go to prison for life, because i had done a terrible thing abusing my brain like this. So i went to prison, where i was instantly dismembered by prison gangs. All my parts were put in a toilet and flushed down. When i got flushed, i came out into a city.

In the city, i couldnt tell what was happening. it was like a mix of every memory i have of cities. I had to re-figure-out geometry to discern the shapes that make reality, and the city turned into my room. Everything was normal, except things were split into lines where i had drawn the shapes. I got mad and threw cheetohs all over my room because they were orange. It had been 5 hours since i dosed. My trip remained like this for the next 6 hours and when i mustered the strength to go outside everything was glowing pink/red/white and had weird tendrils coming off of it.

Mushrooms + Acid:
A friend and I took 3.5g of mushrooms and a tab of LSD around 1 AM, one night. The come up was intense. Everything got very small, i felt like i was running around in a videogame at hyperspeed. Later in the night i was overcome with an intense feeling of knowledge of self and had a ridiculously sharp sense of humor the next day.
Mixing mushrooms + LSD is a different drug than LSD or mushrooms on their own; the playfulness of mushrooms combined with the headfuck from LSD is enough to drive somebody insane, anybody who does this should do it with extreme caution and care for others.
Personally, i locked myself in my room. My friend sexually assaulted a girl and destroyed many relationships on this mix (that night) and i unlocked my door for him to come in, where he told me he loved me and then tore my room apart when i told him i wasnt bi and this was weird. I cant stress this enough - BE CAREFUL WITH YOUR THOUGHTS.

In short:
Anyway, LSD can bind to all sites except 5-HT(3) and 5-HT(4); Psilocin binds to 5-HT(1a) 5-HT(2a) 5-HT(2c). In a recreational dose of LSD, it is more likely than not that it will not bind to all possible receptors at once, leaving room for the psilocin to bind at the same time. Although LSD and psilocin change where they bind as they are metabolized, it does not change the fact that dosing both creates a bank of LSD AND psilocin, not one or the other, that will be drawn upon instead of serotonin. Thus, mixing LSD and mushrooms DOES work (adding mescaline does too); you need to be an experienced user of all three in order to be able to notice the nuances.
In addition, you should be an experienced SELF if you are to take this kind of dose. If you are uncomfortable with your own head, you will undoubtedly hurt yourself on any strong dose of psychedelics. I have done this many times, it is what i love about psychedelics - the ability to hurt myself, see what i am doing to myself, and then come out of it - the triumphant return.

I would strongly advise AGAINST the recreational use of such substances in public to semi-public places such as communal housing or concerts - you can do things you are unaware of, just by thinking about them (if you are on a high enough dose). Anybody thinking of attempting to mix doses or take heroic+ doses should be COMFORTABLE ON THEIR OWN and in a LOCKED ROOM.

Treating yourself like an insane person upon metabolizing such substances is the only way to stay 100% safe (remove all sharp objects, I once [very seriously] asked my friend to kill me and easily would have done it myself because i felt so worthless while on LSD).

psood0nym:
it is not so much that it is a special mix of drugs, but that it is a special state of mind. at least for me, the amount of hype in my own brain surrounding this type of "trinity flip" caused me to call it a "buddha flip" because of the amount of concentration needed not to spiral into a bad trip.

Disclaimer:
1) Don't forget about the fact that you can overload your serotonin receptor sites. This will effect them for a very long time. The come down from the DMT after the "trinity flip" was intense - for 2 days my thoughts were being said by other people AFTER i thought them. No matter what people say, schizophrenia is a very real side effect of hallucinogens and can be provoked by an "ongoing trip" post comedown.

2) Nobody has to agree with anything i say - this is just my knowledge (which is also other people's knowledge) and experience.

 

[Help?!?!]

I would think the holy trinity would be LSD and mescaline....DMT or 5-MeO-DMT at the peak.

Well its always been my personal opinion that everyone's "holy" trip would be a mixture of there own personal favorites, I can say that LSD+Mesc with vaped DMT throughout is a magical ride. To me though, said it a thousand times, but mine is LSD+Mesc+2c-e. Its just so.....perfect. It has everything I want and need in an experience. DMT vaped on that is spectacular as well, thinking on it though I honestly can't think of a time vaped DMT during a trip has failed to make it at least a bit more spectacular, usually leaning more on highly though. I didn't read the entire thread just because theres many long response and i'm simply in quick cruise mode so, for those of you wondering, for me personally theres no difference in potency that I can notice as long as the timing is perfect. I've said this in other threads as well, to truly maximize the experience's potential you must dose each substance accordingly. My plotted dose style for my holy trip is as follows, dose the mesc and 2c-e at T-0, they both begin for me at around 1:30 almost exactly(obviously give or take some time but most its fairly consistent), then at T+1:30 I would dose the LSD. Doing it in this manner, the 2c-e+Mesc are really kicking into gear just as the LSD is begin its magic and by T+2:30 I will be peaking on all three most times. If you fuck the timing up like say take the LSD first it won't work as well, maybe its the truth of the affinities or its just a mental block from that thinking but it seemed that way to me(i'm not talking about simple tolerance either as that won't come into play with much of a real degree as long as you time it right IMO). I will also note that taking extra substances during the trip also works well too, if its LSD and its already T+4:00, say 12 mgs of 4-HO-MET wouldn't add as much if I dosed before T+3:00h. I find though as long as i'm still tripping, dosing on other substances is fairly effective and I can myself bump it up to extremely effective most times if I want by upping the dose further or taking a small 2ish mg bump when the oral dose has really began to set in amongst the others. Adding dissociatives to the mix is really the way to achieve pretty much the most high plateaus attainable IMO. From time to time I stop doing combos and stick to one singular psych, but I just find the experiences so much more colored upon the arrival of multiple players. Once you find your perfect mixes, its just the best. You can reach fairly similar, fairly perfected psychedelic states(obviously anyone experienced knows there will always be a level of variation but to a certain degree...). You can also tweak them to tune them more to your liking by switching doses or changing between DPT/DMT/n2o or K/MXE(obviously be a bit more weary of what you mix MXE with but i've found it plays pretty fairly with most things). Also as always I forgot to add noids in the mix but they are added to everything I do.