Well, I don't want to get all anal, and rip up every little thing, slide 11 is where things start to get rock; in regards to serotonin receptor binding "a critical amount of receptor binding occurs then the axon will fire, causing the release of other neurotransmitters into other synapses", thats not the case at all. You could completely saturate your average cortical pyramidal cell with serotonin and it would fire at all, in fact, it would probably become hyperpolarised, and be less likely to fire.
" When you are happy, it is likely that you have more serotonin receptors activated" <--Huh?
It gives the impression that 5-HTP binds to a 'decarboxylase' to become serotonin.
In regards to receptor downregulation "One theory says they do this in order to avoid getting damaged from over-stimulation" Whos theory, no theory I've ever heard, it doesn't make sense.
" Notice that the prozac fits pefectly into the transporter. Researchers refer to this as "affinity" and say that prozac has a greater affinity for the uptake transporter than other things in the synapse, including serotonin. In other words, Prozac will bind to the transporter first" Not the case. Higher affinity means you need less drug to get higher binding, nothing to do with "first", the impotant this is that the prozac is at high enough concentration to compete for the transporter. And prozac DOESN'T even have higher affinity than serotonin at the transporter.
"Only the animals who got the Prozac during the first six hours showed no damage." No, animals at the 6 hours mark showed marked damage, it was just that it was just significantly different from the untreated animals, i.e. 6 hours was the longest gap they could use and still see any protection.
Their explanation of how MDMA release serotonin is wrong. Slide 21 shows an ancient theory, then slide 21-b shows a newer, but still old theory. Amphetamines probably cause release by stimulating the enzyme Protein kinase C (PKC) to add some phosphate molecules (phosphorylate) to the serotonin/dopamine/noradrenaline transporter, cause it to increase its rate of outward transport.
Oh, and somewhere along the lines they say, MAO-B mediated dopamine degredation directly liberates hydrogen peroxide, which I strongly doubt.
I could go on and be more picky, but those are the ones that stuck out.
