Also, avoid use of haloalkanes such as DCM and chloroform, and of course the notorious carbon tet...although good luck ever finding any CCl4 to begin with, its got a reputation to being the 'organic' solvent spawned from hell, avoid using any of them, as according to a journal article, which I will do my best to dig up from the bowels of my collection on beta-carbolines and decarboxylation of tryptophan and impurities...or might have been another one on analytical impurities found in samples of n,n-DMT that found significant quaternization to give the n,n,n-trimethyltryptammonium quaternary salt (as the chloride of course) produced by reaction of the DMT with the solvent.
This is going to be A-inactive, such a molecular beast possesses a charge, and is thus incapable of crossing the BBB, and B-be as such restricted to the periphery to exert unknown toxic effects (I am not saying it IS toxic....but it WILL be centrally inactive and is an unknown with potential toxic properties..which will then be concentrated in the peripheral nervous system) and might just be quite unpleasant, if not actually dangerous.
I recall that rather uncommon little mushroom by the binomial Inocybe aeruginescens, a member of a large family of relatively nondescript gilled fungi notable for having a somewhat radially fibrous cap, and on the whole, reddish, reddish brown to light brown or tan, along with in many of them a potentially lethal concentration of muscarine, a cholinergic neurotoxin (granted one for which almost without par amongst mycotoxins, with the probable exception of giving either kids/animals who ingest Amanita muscaria benzo treatment in hospital to control seizures and the necessity for GABA agonist+pyridoxal phosphate in the far more serious monomethylhydrazine poisoning that arises from either consuming 'correctly prepared' false morels, incorrectly prepared ones, being the poor bastard that has to COOK the false morels on occasion being poisoned by the fumes they give off, or otherwise being in an enclosed space with a large harvest of a mushroom family its a fairly awful idea to pick for consumption to begin with)
Anyhow...this little Inocybe is different, it produces instead of muscarine, some smallish quantities of psilocybin (and/or psilocin, don't ask me the ratio, or if only one is present, which one. I only just woke up, and I'm about to only just go back to bed

) and as far as it is currently known is the sole producer of the trimethyltryptammonium quat version of psilocybin and IIRC both it, and the bufotenine derivative (bufotenidine is the name of this one IIRC) are quite potent 5HT3 agonists. Central actions of 5HT3r agonists are downright nasty, including nausea, vomiting, anxiety and if not seizure, at least a lowering of seizure threshold. Being a quaternary amine, neither of these will cross the BBB. The peripheral actions aren't much better either, still severe nausea and vomiting and according to wikipedia also acts as an excitatory agent at nociceptive neurons (I.e stimulates pain nerve endings from the sounds of them)
I am not certain that chloroform will alkylate DMT to form the same quaternary ammonium compound that dichlor can, but I wouldn't risk A-wasting DMT and B-turning it into something unknown, but fairly likely to be something pretty unpleasant.