N&PD Moderators: Skorpio | thegreenhand
Cannabidiol is psychoactive to some extent, but it does not produce typical cannabinoid effects like THC does. It's a different kind of psychoactivity.
CBD acts as a CB2 agonist, and a CB1 antagonist. In addition it has agonistic effects on serotonin 1a receptors. CB2 agonism is implicated in the antispastic and immune modulatory effects, CB1 antagonism and 5ht1a agonism cause anxiolysis and relaxation.
Part of the reason CBD is still illegal is because it can be converted into THC through heat, improper storage, and from the presence of acid. This is also why cannabis plants almost always have more THC than CBD. Discussion of the legality and sourcing of CBD is not a topic that's really appropriate here though.
Sekio, Let me know what you think: Should I be concerned abou this conversion if CBD is stored in a glycerin base for ~2 months?
Thanks for understanding Hammilton. My problem is I've never even smoked a cigarette, let alone weed. Don't even drink.
I just thought I'd try a small sample cannabidiol having read so much positive stuff about it.
If you've got any ideas let me know.
also ALL antidepressants are ototoxic
try Etizolam too it is a thienobenzodiazepine that will not affect your tinnitus negatively unlike Alprazolam, clonazepam, lorazepam
do you have any evidence at all to back that up? "antidepressants" covers a fairly wide variety of different chemicals.
why? it hits the same targets as alprazolam etc.
why? it hits the same targets as alprazolam etc.
I thought benzos were supposed to help tinnitus.
My informations come from the Book "ototoxic drugs exposed 3rd edition" which get it sources from the Physicians Desk Reference, the compendium of pharmaceuticals and specialties, the American Health Foundation,the United State Pharmacopeia...
now if you want evidence do yourself a favor and spend less in drugs and buy this book you will have all the references you're looking about
So, not from original research then. "I am right because I have a book that says so" does not really fly, for obvious reasons.
How about you point me to some peer reviewed publications that aren't being sold in a cheap paperback format as a collected review, then we can talk more. PubMed is open access. Doesn't cost anything.
If all these drugs are ototoxic - killing cells in the ear and permanently damaging hearing, I would love to see some evidence, other than a single entry in the Big Book Of Everything Bad For Your Ears, by Dr. Whogivesashit. Is it dose related? Is it related to duration of treatment? Are some A/D's more susceptible than others. Is it reversible. What cells are affected? Can coadministration of drugs (i.e. steroids) fix it. What is the underlying mechanism causing this. How come Wikipedia and the prescribing guidelines don't note ototoxicity as a precaution?
Also, just because a drug causes ataxia, tinnitus, dizziness, vertigo, blah blah, it does not make it *ototoxic*. For instance, getting shittered on alcohol can make you real dizzy. Does that make it an ototoxin? How about spinning around in an office chair really fast? Some people get vertigo when they ingest THC; is it ototoxic too?
So, not from original research then. "I am right because I have a book that says so" does not really fly, for obvious reasons.
How about you point me to some peer reviewed publications that aren't being sold in a cheap paperback format as a collected review, then we can talk more. PubMed is open access. Doesn't cost anything.
If all these drugs are ototoxic - killing cells in the ear and permanently damaging hearing, I would love to see some evidence, other than a single entry in the Big Book Of Everything Bad For Your Ears, by Dr. Whogivesashit. Is it dose related? Is it related to duration of treatment? Are some A/D's more susceptible than others. Is it reversible. What cells are affected? Can coadministration of drugs (i.e. steroids) fix it. What is the underlying mechanism causing this. How come Wikipedia and the prescribing guidelines don't note ototoxicity as a precaution?
Also, just because a drug causes ataxia, tinnitus, dizziness, vertigo, blah blah, it does not make it *ototoxic*. For instance, getting shittered on alcohol can make you real dizzy. Does that make it an ototoxin? How about spinning around in an office chair really fast? Some people get vertigo when they ingest THC; is it ototoxic too?
OH yeah wait a susbstance that cause vestibular dysfonction is not ototoxic i'm must be stupid !Many conditions are associated with dizziness. However, the most common subcategories can be broken down as follows: 40% peripheral vestibular dysfunction, 10% central nervous system lesion, 15% psychiatric disorder, 25% presyncope/dysequilibrium, and 10% nonspecific dizziness
How about spinning around in an office chair really fast?
Oh what a surprise you just discovered that THC is INDEED ototoxic ! ask anyone who have tinnitus, THC worsen their symptoms !Some people get vertigo when they ingest THC; is it ototoxic too?
Actually I looked up that book last night and holy Christ it's a poor resource. Dr. Oz wouldn't even cite that thing