Help Finding Academic Papers

[4DQSAR]

We used to have a thread where people could ask those still in further education or working in an institution with access to journals.

So I've spend a good three days trying to find this BUT it may only be available in paper format (old school):

Zmerman, D.M., Smits, S.E., Hynes, M.D., Cantrell, B.E., Reamer, M., Nickander, R.
'Structural requirements for affinity and intrinsic activity at the opiate receptor defined in 4-phenylpiperidine and related series.
In Committee on the Problems of Drug Dependence 1981. Harris, L.S., ed. Washington, DC: National Institute on Drug Abuse Monograph 41, 1982: 112-1 18.

PMID 6289111

NIDA monographs do not appear to be in any digital archive.

 

[4DQSAR]

NIDA Research Monograph Series #41: Problems of Drug Dependence, 1981: Proceedings of the 43rd Annual Scientific Meeting, the Committee on Problems of Drug Dependence, Inc. : Harris, Louis S. (editor) : Free Download, Borrow, and Streaming : Internet

Presents abstracts and reports on a wide range of issues and research concerning substance abuse. Also: tolerance, precursors of addiction.

archive.org

And to answer my own question - archive.org HAS digitized the thing - but it's (C) so get it while you can.

While DL Zimmermann was clearly a very talented medicinal chemist, I've NEVER seen someone reference themselves on an almost 'industrial' scale. Or, maybe, it's just that in the 80s when full agonists were out, Eli Lilly were prepared to investigate the unusual activity of picenadol.

But why is one enantiomer a potent agonist, the other a weak antagonist? That chiral enantiotropic methyl group. But CIS, not TRANS (so the opposite of prodine). It seems possible phenolic opioids bind at a different part of the receptor domain but the very last paper notes that the analgesic activity is equally mediated by mu and delta activity.

 

[someguyontheinternet]

I suspect you may be able to find many papers using ILL. Libraries are usually happy to scan in paper copies if they get requested

 

[4DQSAR]

Yeah - I tend to be looking at stuff only a few university libraries would have. But all credit to archive.org - I found the index paper I wanted.

BTW severely physically disabled so going places kind of tricky.

Still, thanks for thinking of me.

 

[Skorpio]

I don’t have academic journal access anymore, but for papers at least 5 or so years old, scihub has a pretty good hit rate.