• Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Misc Healthier alternatives to mirtazapine

Artificial Emotion

Bluelighter
Joined
Jan 19, 2009
Messages
5,314
Location
UK (Kent)
I've been taking mirtazapine for years and cannot sleep without it. I went for 15 months without it once and for the whole period was unable to get any quality sleep at all which drove me crazy. It's as if the drug has permanently changed my brain chemistry. However I do not want to go on taking the drug since I am not suffering from clinical depression (and neither are the 80% of people who take antidepressant drugs!!) so I'm looking for an alternative that acts on a similar part of the brain. Promethazine and diphenhydramine are useless so I need something else. If anyone has any suggestions it would be great.
 
Are you thinking about looking more specifically at sedative-hypnotics? Sounds like you want a very specific acting drug, targeting issues of insomnia?

I wonder though, is why you'd want to switch it up if it's working for you. Even though you don't suffer from depression, why change your medication is it's working, just because it is also used in others as an anti depressant? Many meds are used off label to treat other illnesses than they were otherwise intended - and work really good at it.

Since almost all your alternatives are either going to be likely too weak for your needs (melatonin, valerian root, etc.), others with too many side effects (seroquel, risperdone, etc.) and yet others that are highly prone to addiction (z-drugs, benzos, ect), why not just stick with what you got? I mean, from what you've said, I don't see any benefit in trying something else?

Why did you go off it for 15 months? I don't mean to be argumentative here, but, coming from someone who's been there, a lot of sleeping meds come at a huge cost. So one with fewer side effects, such as the one you're on, comes are and works well for someone, well shoot, that sounds like pretty good news.

Ime, I found that my insomnia was mostly a routine/lifestyle issue. Eating right, exercising, and healthy sleep habits (and even more so healthy living habits), along with melatonin once in a while, well, that was enough to get me back on track.
 
Begin the OP hasn't come back maybe I can answer some of these as I was scripted this before for sleep.

Mirtazapine, when used for sleep, is a very odd drug. Yes it will knock you down but it isn't like a benzo or the z-drugs at all. It gives you the most insane, wacky, and just plain crazy dreams you've ever had. I'd compare those to delirium because you're nearly lucid (not enough so that you know you're dreaming) and the dreams are just so odd....

Some examples:

- Looked for my father for hours while he randomly appeared behind stuff in my bedroom, waved, then hid behind whatever object. I'd go look behind the object just to see him somewhere else.

- Ran a con on my grandmother and convinced her to give me xanax and Tussionex a little at a time. This dream felt like it went on for weeks, because I was saving what she gave me for like a week to get high on it on Fridays. I dunno, don't ask me, as far as I know she isn't even scripted those anymore.

- Robbed a gas station (something I've never done or would do) with two friends that I have not seen in 5 years. We had a big shoot-out and everything.

- Helped my friend fix his truck, that he sold about 10 years ago.

- Had sex on the moon (this one was alright).

Anyway you see my point, the dreams are enough to get anyone to think twice before taking this stuff. I only take it as a last resort these days. I still have a bottle from two years ago with about 10 tabs in it.

Another concern in price, I won't give you an exact number but lets just say this stuff doesn't come cheap if you don't have health insurance.

Finally, the effects you get if you take it everyday. About two weeks in it starts putting me in a "manic" state of mind and I'm just not me... Again, this is enough to make you think twice about taking it.

I also took myself off of it, and told the doctor I was doing so. He didn't complain because it was like the third anti-depressant I had tried taking for sleep, all of them having bad side effects. Don't even get me started on trazadone...

To the OP: If you're like me, you might have to face reality and start considering a benzo or z-drug for your problems. Some of us are just in that group I'm afraid. If you have a regular doctor he should be more than willing to try something like a benzo if you've gone through the anti-depressant dance already. Just make sure you give this stuff at least a month to work its way out of your system. I was not on it as long as you, but I was on it long enough to feel the effects of it begin constantly in my system and like you I did not like it one bit. You're not "perma-fried" by any means, it'll just take some time before the chemical balance in your brain returns to normal.

I am not a doctor and my sleeping problems are a direct result of brain trauma. Don't assume my situation is anything like yours or that I know what I'm talking about. ;)

One last bit of advice: If you go on benzo's or a z-drug try not to take it every night. Use it as a last resort. I'll pull 48 hour wake cycles before I even think about taking a xanax these days.
 
Benzos and z-drugs are way way out of the question. I've been on them long term and whilst they worked for me for the first couple of weeks, eventually they stopped working. Benzos are probably more of a threat to my health than the mirtazapine. Long term benzo use has been linked to cancer I believe, as we saw in the news recently. How strong the link is, I don't know, but I don't want to put up with another drug dependency.

I might try a pure indica to see how that works. Something like a pure afghani would be great, especially if eaten as edibles.

One thing I wanted to know about the mirtazapine, could it be responsible for my appetite problems? I get so hungry, especially during the middle of the night, that I have been known to eat whole jars of peanut butter (seriously). Weed would probably be an issue in that respect, so I might have to play with different strains.

As for the question about why I stopped the mirtazapine - I was an inmate in a nut house and they decided to take me off it against my will in favor of something else. I was a political prisoner there imo but that's a whole different story.
 
I've used mirtazapine on and off for several years, both because of it's antidepressanta and hypnotive effects. I mean it's still better for sleep than quetiapine (Seroquel) which is just a nasty drug in every way (I used it for many years for sleep). I'm on 15 mg mirtazapine now, mainly for sleep and social anxiety but it has never made as lethargic as now. The first few weeks you always feel tired, spaced out and lethargic but this has lasted far longer. I'm going to switch back to escitalopram which I used before because it was much more effective for soxial anxiety.

Mirtazapine increases appetite and usually produces a significant weight gain, both due to water retention and an absolute horribly strong craving for anything sweet. This is one of it's most common side effects and one of the reason it's effective in treating anorexia.

But the sleep issue is a problem indeed. After years of quetiapine and mirtazapine I had problems finding anything that puts me to sleep (I'm already a benzo addict so benzos and z-drugs are out the question). Strangely enough I found remedy in one of the mildest sleep aids there are; melatonin. In some (maybe most?) countries it's prescription free. Have you tried melatonin? For some it has virtually no effects and for others it's quite effective (as for me). It makes you tired in a "normal" way, you don't get knocked out by it. The downside with using melatonin as a a supplement is that as it's your brains natural sleep hormone, taking it as a supplement may interfere with you brains normal production of melatonin, and it can be hard to get sleep when stopping it. On the other side it's probably the safest sleep aid there is with no addiction or nasty side effects. After all, it's your brains natural sleep hormone.

Oh and regardin vivid and bizarre dreams, they are indeed that on mirtazapin, but add melatonin in to the mix and THEN you'll have some seriously twisted dreams they feel so real that they can haunt you for days after (literally).
 
Last edited:
Yea, OP, this drug is known to increase one's appetite, and ridiculously so at time. I can totally understand not wanting to take it just for that reason, especially if it compels you to eat a whole jar of peanut butter (again, I can sympathize).

So, what about melatonin, as the above post also asks?
 
Yea, OP, this drug is known to increase one's appetite, and ridiculously so at time. I can totally understand not wanting to take it just for that reason, especially if it compels you to eat a whole jar of peanut butter (again, I can sympathize).

So, what about melatonin, as the above post also asks?

Yea it did that too me as well, I would eat all the ice creme and candy in the house when I was on this stuff. For me it wasn't effective for putting on weight because I have other issues.

I've tried melatonin and just about every other OTC and "home" remedy for sleep. None of them were effective for me and I've just gotten to the point where I have to put "knocked out" to sleep. I can achieve that either through staying up for about 48 hours or taking something that will put me down. Usually that something is a benzo these days but as I said before I like to space out when I take it so that it will remain effective.

I'm this way as a direct result of multiple concussions, and I know that because I never had issues with sleep before I had them. I had to go through lots of doctors before one would finally look into this without sending me out with a prescription for "random sleep remedy of the month". I don't know if the OPs situation is the same as mine, and I agree Melatonin would be a good place for the OP to start. But there are people out there that have to been "knocked out" to achieve sleep at the times society deems acceptable.

Honestly if I were allowed to keep my own hours I'd just stay up for two days then sleep for a day, but society says I can't do that and hold a regular job so I eat a benzo three days out of the week. :(
 
mirtazapine is a very strong H1 receptor antagonist, and as a result causes intense sedation and hypnotic effects. substitute in 50mgs diphenhydramine (benedryl) as a "healthier" alternative. hydroxyzine would be the best bet, but that requires a prescription from a doctor in most countries.
 
Top