how much should i take if i can take 15 or more of the 10mg vic's with no side effects other than just kinda tired . i usually take 5 at once then a few every hour. i tried nucynta but only one a day i am looking for recreational value or how to beat the time release? i took tramadol and it didnt do anything to me i would take as many as i could without thinking i was gonna die and nothing from tramadol.
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N&PD Moderators: Skorpio | someguyontheinternet
Has anyone had personal experience with Nucynta/Tapentadol
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sekio
Bluelight Crew
If you are tolerant enough to not get an effectoff 150mg hydrocodone I doubt you will feel tapentadol.
iowabobby69
Greenlighter
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Hi, I have been on the 50mcg fentanal for about a year and half changing every 48hrs. I started having WD's. and my doc gave me the script for nucynta. Do you know how it compares to oxy? I take 50mg 4 times a day and I still have pain but the WD's went away. The cost of the nucynta is killing me and I would prefer a generic but there isn't one. Do you think a doc would switch it to oxy for the cheaper price. Plus it doesn't do much for pain control.
sekio
Bluelight Crew
Oxycodone is much stronger than tapentadol, and no I do not expect a doctor would substitute oxy for tapentadol.
This is not the place to discuss prescribing guidelines anyway.
This is not the place to discuss prescribing guidelines anyway.
weekend addiction
Bluelighter
Its a cool drug similar to tramadol a bit pscyhadellic in high doses. Would love to do some again soon!
Condumbpope
Bluelighter
Personally Nucynta is a a decent painkiller, I've been prescribed some in the past... however it did make me irritable, and "wired"... more so than Tramadol.
XR Tramadol has less of a jittery feeling than either, and is the best IMO.
XR Tramadol has less of a jittery feeling than either, and is the best IMO.
SaosinEngaged
Bluelighter
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I think, like it's little brother (sister? 
) Tramadol, Tapentadol ends up being widely variable in effects from person to person. IME, some people report euphoric effects, others do not feel a thing other than a hydrocodone style body buzz. I have personally experienced Tapentadol on several occasions back in the days when my Oxy tolerance was negligible to low and I've taken 50mg (to test the waters), 100mg, and 150 mg doses and never really noticed any effects to write home about. For me, it had a "slight mood lift" and a generalized feeling of body load. That was about it, even on a dose of 150mg which, at the time, was "more" than any equivalent Oxy dosage I'd taken.
IMHO, I think Tapentadol is highly variable from person to person, just like Tramadol.
This is also before I needed opiates for pain management (hadn't had my back EXPLODED by a drunk driver yet
) so I can't comment too much on its efficacy as a painkiller, although I'm certain it's more than adequate in most cases. Personally, I don't think the FDA would approve (in this day and age) a new CII narcotic centrally active painkiller unless it demonstrated fantastic analgesia in the trials.
) Tramadol, Tapentadol ends up being widely variable in effects from person to person. IME, some people report euphoric effects, others do not feel a thing other than a hydrocodone style body buzz. I have personally experienced Tapentadol on several occasions back in the days when my Oxy tolerance was negligible to low and I've taken 50mg (to test the waters), 100mg, and 150 mg doses and never really noticed any effects to write home about. For me, it had a "slight mood lift" and a generalized feeling of body load. That was about it, even on a dose of 150mg which, at the time, was "more" than any equivalent Oxy dosage I'd taken.IMHO, I think Tapentadol is highly variable from person to person, just like Tramadol.
This is also before I needed opiates for pain management (hadn't had my back EXPLODED by a drunk driver yet
) so I can't comment too much on its efficacy as a painkiller, although I'm certain it's more than adequate in most cases. Personally, I don't think the FDA would approve (in this day and age) a new CII narcotic centrally active painkiller unless it demonstrated fantastic analgesia in the trials.
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fastandbulbous
Bluelight Crew
My personal experience is with talpentadol administered rectally for the back and foot pain that are a result of not acting my age (bones break easily when you're my age). It was meant to be administered orally, but at only 30% bioavailability (due to 1st pass metabolism by the liver), I opted for rectal administration (NOT what the doctor ordered! 
).
While primarily an opioid, there is a distinct stimulant character to noradrenaline reuptake inhibition (where you get noradrenergic effects, dopaminergic effects are common & vice versa), which I quite like, as I'm not a fan of the inertia of morphine. There is an element of anxiety, but that is easily dealt with
by small doses of benzodiazepines, when they occasionally occur.
Dosage wise, I find 50mg rectally every 4-6 hours keeps the pain away and keeps me amused. I hope there aren't significant w/d effects: at least no more than my permanent prescription for dihydrocodeine will deal with.
In terms of structure, it overlays opioids like hydroxypethedine, but the amine group being 3 carbon atoms from the benzene ring makes it slightly similar to amphetamine (or cocaine) and that's what I think the noradrenergic effects come from (there's a Ph.D. thesis paper that covers the structure of the dopamine receptor and associated dopaminergic SAR that makes for interesting reading).
Anyway, it gets my vote
).While primarily an opioid, there is a distinct stimulant character to noradrenaline reuptake inhibition (where you get noradrenergic effects, dopaminergic effects are common & vice versa), which I quite like, as I'm not a fan of the inertia of morphine. There is an element of anxiety, but that is easily dealt with
by small doses of benzodiazepines, when they occasionally occur.
Dosage wise, I find 50mg rectally every 4-6 hours keeps the pain away and keeps me amused. I hope there aren't significant w/d effects: at least no more than my permanent prescription for dihydrocodeine will deal with.
In terms of structure, it overlays opioids like hydroxypethedine, but the amine group being 3 carbon atoms from the benzene ring makes it slightly similar to amphetamine (or cocaine) and that's what I think the noradrenergic effects come from (there's a Ph.D. thesis paper that covers the structure of the dopamine receptor and associated dopaminergic SAR that makes for interesting reading).
Anyway, it gets my vote
Smyth2
Bluelighter
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- Jul 26, 2011
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That hydrocodeine thing you have going on has been with you from almost as far back as i can remember. I noticed that one of the reasons buprenorphine is being scripted is for chronic pain. I never tried any of it, but maybe for you, you would be able to get some of it?My personal experience is with talpentadol administered rectally for the back and foot pain that are a result of not acting my age (bones break easily when you're my age). It was meant to be administered orally, but at only 30% bioavailability (due to 1st pass metabolism by the liver), I opted for rectal administration (NOT what the doctor ordered!
While primarily an opioid, there is a distinct stimulant character to noradrenaline reuptake inhibition (where you get noradrenergic effects, dopaminergic effects are common & vice versa), which I quite like, as I'm not a fan of the inertia of morphine. There is an element of anxiety, but that is easily dealt with
by small doses of benzodiazepines, when they occasionally occur.
Dosage wise, I find 50mg rectally every 4-6 hours keeps the pain away and keeps me amused. I hope there aren't significant w/d effects: at least no more than my permanent prescription for dihydrocodeine will deal with.
In terms of structure, it overlays opioids like hydroxypethedine, but the amine group being 3 carbon atoms from the benzene ring makes it slightly similar to amphetamine (or cocaine) and that's what I think the noradrenergic effects come from (there's a Ph.D. thesis paper that covers the structure of the dopamine receptor and associated dopaminergic SAR that makes for interesting reading).
Anyway, it gets my vote
fastandbulbous
Bluelight Crew
I've tried buprenorphine before and it turned into a sad tale of nausea and anxiety. TBH, talpentadol is too nice and I find myself taking doses when the pain is under control. Think it may be time to initiate my w/d free dosage regime.
I think it says something that the BNF even cites specific papers to undertake the detoxification of patients dependent on tapentadol. Briefly, 'see-sawing' is the most effective strategy i.e. for formulations taken twice daily, one of the two doses is reduced until symptoms abate, then the other is reduced... and repeat.
Why? Because it appears that while tapentadol doesn't have particularly good affinity for the MOR, it is a SUPERagonist.
It's fascinating to read the clinical development. We have sufficient research to assert that phenolic opioids with a benzylic side-chain, a methyl will be an antagonist, an ethyl a partial agonist and an n-propyl, a full agonist. BUT the fact that in this case an ethyl moiety acts as a superagonist does rather present the question 'so, what's the n-propyl analogue like' and the answer is that we don't know. The developers very carefully avoided any record of such compounds ever being produced.
I think the thought that the (S,S) enantiomer of 3-methyl ketobemidone may actually be a potent agonist. When Otto Eisleb researched the phenylpiperidine class of opioid, either optical resolution wasn't practical (at least for production quantities) or it's important wasn't appreciated. Sadly, Otto is just one more person who likely knows for certain but sadly for us, has passed on.
But I would be pretty confident that tahexadol would be a more potent opioid. FYI 3 of the 4 possible enantiomers of 'tahexadol' are available to researchers. Guess which one ISN'T available? Can we infer that those who supply such chemicals have decided that they do not wish to offer what might be a novel and legal MOR? Who knows.
Why? Because it appears that while tapentadol doesn't have particularly good affinity for the MOR, it is a SUPERagonist.
It's fascinating to read the clinical development. We have sufficient research to assert that phenolic opioids with a benzylic side-chain, a methyl will be an antagonist, an ethyl a partial agonist and an n-propyl, a full agonist. BUT the fact that in this case an ethyl moiety acts as a superagonist does rather present the question 'so, what's the n-propyl analogue like' and the answer is that we don't know. The developers very carefully avoided any record of such compounds ever being produced.
I think the thought that the (S,S) enantiomer of 3-methyl ketobemidone may actually be a potent agonist. When Otto Eisleb researched the phenylpiperidine class of opioid, either optical resolution wasn't practical (at least for production quantities) or it's important wasn't appreciated. Sadly, Otto is just one more person who likely knows for certain but sadly for us, has passed on.
But I would be pretty confident that tahexadol would be a more potent opioid. FYI 3 of the 4 possible enantiomers of 'tahexadol' are available to researchers. Guess which one ISN'T available? Can we infer that those who supply such chemicals have decided that they do not wish to offer what might be a novel and legal MOR? Who knows.
Smyth2
Bluelighter
- Joined
- Jul 26, 2011
- Messages
- 439
This looks like an interesting observation.
It will be interesting to test your hypothesis that tahexadol has a qsar overlay that corresponds to profadol and picenadol.
You can't set it up for free though so most likely you will have to wait for someone else to consider it.
It's a good idea if it works but to the best of my knowledge it is still only an educated guess and is not empirically proven.
Are you saying you would ask the Chinese to set it up for you? I thought you have a phd though so are you too disabled to do it yourself?
It will be interesting to test your hypothesis that tahexadol has a qsar overlay that corresponds to profadol and picenadol.
You can't set it up for free though so most likely you will have to wait for someone else to consider it.
It's a good idea if it works but to the best of my knowledge it is still only an educated guess and is not empirically proven.
Are you saying you would ask the Chinese to set it up for you? I thought you have a phd though so are you too disabled to do it yourself?
Mushoku_Sensei
Bluelighter
My personal experience is with talpentadol administered rectally for the back and foot pain that are a result of not acting my age (bones break easily when you're my age). It was meant to be administered orally, but at only 30% bioavailability (due to 1st pass metabolism by the liver), I opted for rectal administration (NOT what the doctor ordered!
While primarily an opioid, there is a distinct stimulant character to noradrenaline reuptake inhibition (where you get noradrenergic effects, dopaminergic effects are common & vice versa), which I quite like, as I'm not a fan of the inertia of morphine. There is an element of anxiety, but that is easily dealt with
by small doses of benzodiazepines, when they occasionally occur.
Dosage wise, I find 50mg rectally every 4-6 hours keeps the pain away and keeps me amused. I hope there aren't significant w/d effects: at least no more than my permanent prescription for dihydrocodeine will deal with.
In terms of structure, it overlays opioids like hydroxypethedine, but the amine group being 3 carbon atoms from the benzene ring makes it slightly similar to amphetamine (or cocaine) and that's what I think the noradrenergic effects come from (there's a Ph.D. thesis paper that covers the structure of the dopamine receptor and associated dopaminergic SAR that makes for interesting reading).
Anyway, it gets my vote
I have to try it rectal then!! 200 mg oral is a good buzz for me and I'm still very functional+ pain free. How's the rectal bioavailability then compared to 30% oral??
fairnymph
Ex-Bluelighter
I hate tapentadol. It’s almost completely useless for pain and gives a very dirty body load with a nasty headache. Tramadol is much the same for me.
Mushoku_Sensei
Bluelighter
Hmm. Clearly different metabolism.. both work very well for me, but ik that they don't for many...
Mushoku_Sensei
Bluelighter
So I tried and half the dose rectal gave me a nod (maybe 30-60 min max) but it didn't even last 3 hours 
- double dose oral definitely lasts longer!
- double dose oral definitely lasts longer!
fairnymph
Ex-Bluelighter
Rectal doesn’t work well for me, regardless of the drug. I need WAY more than I would need nasally or sometimes even orally, and I just don’t get a very strong effect.So I tried and half the dose rectal gave me a nod (maybe 30-60 min max) but it didn't even last 3 hours
Mushoku_Sensei
Bluelighter
I like it normally because it's safe and convenient, but that much shorter is too much
