• Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Misc GHB + amphetamines - Weird problem

iconoclast56

Bluelighter
Joined
Feb 4, 2012
Messages
94
I take GHB to sleep after I'd been on amphetamines during the day but something very strange and worrying has happened a few times now. Usually I wake up the next morning with an uncomfortable dopamine rebound and when I take dexedrine, the dopamine rebound goes away much quicker than usual. Today though, I woke up and I felt good. No dopamine rebound at all. This doesn't make sense because I ingested way too much GHB yesterday in my attempts to get to sleep so if anything, the rebound should have been worse than usual. Anyhow, I took some dexedrine and felt fine for 4 hours but then something changed, my hearing has got much poorer, I'm feeling pressure and tingling on my head and face and I'm nervous. This has happened to me before, a few weeks ago when I was studying for my exams. It happened 3 days in a row. Last time this happened, it got very bad and lasted something like 8 hours. Its only just started now so I'm worried. I don't want to deal with this again but I have no idea what it is, let alone how to stop it. My only theory is that I might be physically addicted and that the combination of the dexedrines effects and the GHB withdrawal is doing this to me. I'm considering taking a small dose of GHB to see if it makes it stop but I'm reluctant because I have never tried taking GHB WHILE I was on dexedrine. Then again, theres usually some dexedrine still left in my system when I go to bed at night so if it was a dangerous combo for me, I'd probably know it by now. Any advice? I don't know what to do. This always happens at the worst possible times, right now I have lots of work to do and was planning on spending the next 15 hours working on something.

EDIT: I should mention that the physical symptoms are pretty worrying. I went to the doctor the day after it happened last time and she said my ears were actually swollen, which would explain the hearing loss. Right now I feel like my whole head is swelling.
 
I figured I have nothing to lose at this point so I took .5g of GHB and I no longer feel like I'm going to die which is a good sign lol. I still feel very strange though. At least now I can work but I'd like to know what the hell is going on.
 
The same situation made me so panicked that I went to the hospital.

It sounds like a case of panic disorder from withdrawals.

What you need to do is to not ingest any GABA-ergic type drugs for a fairly long time. Restore your body's natural ability to lower glutamate levels. When the brain is sped up, and cannot slow down thoughts due to deficiencies, a person will have very uncomfortable feelings that can explode into full-blown panic attacks.

GHB should not be used to sleep, and if you use it in conjunction with amphetamines, you will need to taper off the high dose you probably needed to get high.

All in all. You should save a little emergency GHB to taper off any withdrawals you may have in the future. Do not take stimulants during withdrawals. Withdrawals begin (for me) roughly 4-6 hours after the last dose. Mild withdrawals can be snuffed out with as little as a gram of GHB.
 
Last edited:
Really, you had the same kinda situation? Can you describe it. I'm still fairly freaked out about the whole thing. If it is what you say it is then I'm still in trouble because I read that excessive glutamate kills neurons. I know very little about this neurotransmitter, does it bond to the NMDA receptor? If so, the magnesium supplements I took should help a bit.
 
Yes, addiction to GHB is neurotoxic and if you're suffering withdrawals you should discontinue taking it immediately. In conjunction with amphetamine you have a pretty nasty depression upon immediate cessation of your meds. I was using amphetamines and GHB for a short amount of time, but after a few days I felt fine.

To be honest, I believe GHB should only be used once a week at most in doses of about 1.5 to 2 grams. With as little as 2 redoses.

What helped me the best was L-tryptophan to be honest. It slowed my thoughts down quite a bit.
 
Lately I've only been taking dexedrine on the weekends and only been taking GHB to sleep for 4 days of the week. So the neurotoxicity of GHB is caused by glutamate excitotoxicity? Would a good NMDA antagonist protect the brain in this case? I'm a chem student, I can't afford to be losing braincells like this. I hadn't taken GHB at all for 3 days but last night I messed up my sleeping doses and ended up staying awake and repeatedly redosing for half the night and consumed over 10g of the stuff in total.
 
Lately I've only been taking dexedrine on the weekends and only been taking GHB to sleep for 4 days of the week. So the neurotoxicity of GHB is caused by glutamate excitotoxicity?

As far as I know, yes. ADD will be more lucid on prevention on information concerning the NMDA receptor.
 
Can you describe the experience you had that prompted you to check into the hospital. I want to see if it is indeed the same experience that I have been having.
 
Withdrawal Experience:

My hands start feeling warm and a light tickling sensation is flowing through them as if they are in a tub of warm water. My head and face start to feel warm as well, but sort of numb as well. Especially my lips.

The most key part is the painful bout of anxiety at the pit of my stomach. Butterflies in the stomach? No. These butterflies are more like a heavy lump.

I will sometimes start shaking uncontrollably. During certain points of withdrawal I will become extremely cold despite being in a warm environment. I will get goosebumps and generally feel very ill. It is nearly impossible to sleep, so I will lie down. When people ask me for anything, I feel too weak to help, or like strenuous activity will kill me. Fortunately time seems to go by very quickly.

I believe this is because my memory is completely shot at this point. During the peak of the experience I will believe things that are not real fairly easily. Sometimes I will have very strange psychedelic thoughts. I kept picturing moving fractals and objects in black and white that were flying. (If you are having those symptoms then it's definitely best to stop.)

Now as for when I mixed amphetamines and GHB and went to the hospital: http://www.bluelight.ru/vb/entries/5300-Methamphetamine-The-Last-Line.
 
I'm not convinced that they are the same type of experience but there are similarities. My hands and feet just stayed ice cold the whole time. My hands went blue. All that was an indication of poor circulation. I took some ginkgo biloba to remedy that but it didn't do much. I was regularly checking my pulse and blood pressure with a home blood pressure monitor and surprisingly, it was always normal. Well not exactly. My pulse was always extremely low for being on amphetamines. I checked my blood glucose level and it was a bit low but in the normal range. GHB regulates my body temperature well for some reason. Now that I redosed, my hands and feet have warmed up. This is the first time I've dosed 24/7. This drug causes me mad trouble, its not worth the ability to sleep it gives me. I wish I had an alternative.
 
I'm not convinced that they are the same type of experience but there are similarities. My hands and feet just stayed ice cold the whole time. My hands went blue. All that was an indication of poor circulation. I took some ginkgo biloba to remedy that but it didn't do much. I was regularly checking my pulse and blood pressure with a home blood pressure monitor and surprisingly, it was always normal. Well not exactly. My pulse was always extremely low for being on amphetamines. I checked my blood glucose level and it was a bit low but in the normal range. GHB regulates my body temperature well for some reason. Now that I redosed, my hands and feet have warmed up. This is the first time I've dosed 24/7. This drug causes me mad trouble, its not worth the ability to sleep it gives me. I wish I had an alternative.
Stop. You wont regret it. If you dont drink Water it can make your hands and feet feel kinda weird when you bend them around.
 
I'm not convinced that they are the same type of experience but there are similarities. My hands and feet just stayed ice cold the whole time. My hands went blue. All that was an indication of poor circulation. I took some ginkgo biloba to remedy that but it didn't do much. I was regularly checking my pulse and blood pressure with a home blood pressure monitor and surprisingly, it was always normal. Well not exactly. My pulse was always extremely low for being on amphetamines. I checked my blood glucose level and it was a bit low but in the normal range. GHB regulates my body temperature well for some reason. Now that I redosed, my hands and feet have warmed up. This is the first time I've dosed 24/7. This drug causes me mad trouble, its not worth the ability to sleep it gives me. I wish I had an alternative.

Well GHB alters your potassium levels- this can effect circulation and cause an irregular heart rate.

Amphetamine is a vasoconstricter and it can cause coldness in the extremities, therefore one may feel like their hands and feet are cold. (This is probably your best explanation of the coldness)

One important thing to note about anxiety disorder is that: the very fact you're so self-conscious of your body and that you probably have an above-average understanding of medicine will exacerbate the effects. Even if you knew 100% what was wrong with you during a panic attack, you will still find a way to doubt yourself or the doctor that diagnosed you.

It's hell on earth and there is no greater way to castrate your sense of logic than to have a panic attack. If anyone has shook hands with death, it's anyone with Panic disorder. A nurse at a doctor's office said she phoned the ER when she was having one; proof that it causes a person to completely lose sight of whats true and false.

My best word of advice is to not use GHB and discontinue using stimulants for at least 3 days to let your receptors repair. You may still experience anxiety while on your medication for a long time, try halving the dose. Best of luck.

Renz, what dosing regimen of L-tryptophan were/are you using?

Anywhere from 500mg to a 1,500mg - Going above a gram is pretty pointless IMO. If I am experiencing withdrawals it won't put me to sleep, but it helps slow my mind and get through the day. I believe it makes the withdrawals less lengthy.
 
Last edited:
Interesting, I've used 5-HTP and l-tyrosine during amphetamine WDs and its certainly effective...

L-phenylalinine, caffeine or DMAA are what helps me the most during a stimulant withdrawal.

But Stimulant w/ds and GHB w/ds are the complete opposite issue in treating.
 
I managed to ingest a total of 30g yesterday which is a lot for someone who isn't a 24/7 user. I thought the dopamine rebound would be pretty hardcore but its not that bad. Its been 3 hours since I woke up and I'm just feeling a bit nervous. I'm feeling this tingling in my head every now and again though which probably isn't a good sign.
 
Its been about 5 hours since I woke up and I feel great. I'm suddenly bursting with euphoria. Does this mean I'm not addicted? In other words, if I were addicted, wouldn't withdrawal kick in about now?
 
Well GHB alters your potassium levels- this can effect circulation and cause an irregular heart rate.
Thats sodium GHB. When you ingest large amounts of sodium oxybate, you're ingesting large amounts of sodium ions which alters the ratio of sodium to potassium ions in your body. I've been taking potassium GHB. Most people have too much sodium and not enough potassium so I think its better to be ingesting large quantities of potassium than sodium but shifting the balance in the opposite direction will also cause potentally life threatening physiological changes. The healthiest way to take GHB would be to take a mixture of sodium, potassium, magnesium and calcium GHB in the right proportions. The magnesium would help prevent glutamate excitotoxicity by partially blocking NMDA receptors and calcium facilitates absorption of magnesium.

Amphetamine is a vasoconstricter and it can cause coldness in the extremities, therefore one may feel like their hands and feet are cold. (This is probably your best explanation of the coldness)
Yeah, amphetamine always makes my hands and feet cold but GHB dopamine rebound is WAY more extreme. Right now I have 3 pairs of socks on and my feet are still cold. When I wake up in the morning under the blanket with a dopamine rebound, its the other way around, I'm way too hot. This is definitely poor circulation.

One important thing to note about anxiety disorder is that: the very fact you're so self-conscious of your body and that you probably have an above-average understanding of medicine will exacerbate the effects. Even if you knew 100% what was wrong with you during a panic attack, you will still find a way to doubt yourself or the doctor that diagnosed you.

It's hell on earth and there is no greater way to castrate your sense of logic than to have a panic attack. If anyone has shook hands with death, it's anyone with Panic disorder. A nurse at a doctor's office said she phoned the ER when she was having one; proof that it causes a person to completely lose sight of whats true and false.
I think the anxiety I've been getting is pretty mild but its still horrible. I'm completely immune to it ordinarily, the only time I've experienced it is coming down off GHB. I strongly suspected GABA_B receptors are the most significant factor behind ones susceptibility to anxiety. I had never messed with my GABA_B receptors before trying GHB.

My best word of advice is to not use GHB and discontinue using stimulants for at least 3 days to let your receptors repair. You may still experience anxiety while on your medication for a long time, try halving the dose. Best of luck.
First time this happened, I stopped taking dexedrine for a week. The next time I used it, I was fine. This is a very bizarre drug interaction. Today, I didn't take any dexedrine and after the 4 hour mark, I entered this weird euphoric state. I'm still in this state now. If I took dexedrine right now, I bet it would turn back into that horrible state I was in yesterday. It seems to be the combination of dexedrine and the state that I am in now that produces that horrible state I described in the OP.


Anywhere from 500mg to a 1,500mg - Going above a gram is pretty pointless IMO. If I am experiencing withdrawals it won't put me to sleep, but it helps slow my mind and get through the day. I believe it makes the withdrawals less lengthy.
Tyrosine does nothing to me. I'm going to order some l-dopa which is definitely superior since its used to treat Parkinsons disease.
 
Top