ThePharmacist4925
Bluelighter
- Joined
- Apr 10, 2013
- Messages
- 383
I would like to start out by saying I am not a doctor, never will be a medical doctor, do not really want to be a medical doctor, am not a substitute for a medical doctor or whatever the fuck else people might claim I'm trying to be. I'm just an avid reader that dose research by reading studies, forums, patents, erowid, and doing self-experimentation. I think this shit is fun, don't penalize me for my lack of a college education. Thank you for your consideration and cooperation.
Gabapentin is regularly used, whether as a placebo or not, to treat seizures, anxiety, and nerve/neuropathic pain. I'd say many patients find gabapentin useful and would continue its use even if for some reason they had to pay out of pocket for the prescription. This says something in a world of pharmaceuticals that don't really do much of anything perceived as helpful or curative/palliative by patients. Gabapentin is not magical, but it happens to be more useful than many other drugs.
I've heard of people taking massive quantities in an effort to get high and failing miserably, sure its nice, but given what we know about its pharmacokinetics, taking a massive dosage all at once is naive and relatively pointless in the scheme of drug use. I've also seen people post around the web about their addictions to gabapentin, these reports I find rather odd as people are still taking about 3grams at a time
hoping get high, squandering massive prescriptions in a matter of days. I am an addict, the addiction part I get, but the large doses are just a waste of a good pharmaceutical, you would think people might learn. This is a moot point and I will now move on.
I had the good fortune of meeting with the psychopharmacology expert for both The Menninger Clinic and Mclean Hospital this year. I will state bluntly that Mcleans psychopharmacology expert is clearly an avid textbook connoisseur and I congratulate him on his ability to read and regurgitate medical books; boring guy, relatively unhelpful, didn't tell me anything I wasn't already aware of. The psychopharmacology expert for The Menniger Clinic was very personable and I enjoyed my debate with him over the efficacy of different dosing regiments of gabapentin. I know that the human body can only utilize so much gabapentin at one time. Besides using snacks and Aleve to potentiate it, the body seems to put to use about 200mg of a 300mg capsule give or take every 45 minutes to 90 minutes. More can be squeezed through by increasing bioavailability or taking mass doses, this is generally a waste of gabapentin though. Ultimately the stance of the Menninger psychopharm expert was that the area under the curve was the same dosed at 600mg 3x daily or 300mg 6x daily. I couldn't resolve the area under the curve issue with him, I am sure the AUC for gabapentin must be higher if dosed more often if the daily total dosage is the same. My psychopharmacologist when i was at Austen Riggs declined to comment on the matter, so be it. My outpatient psychiatrist let me switch my dosing from 3x daily to 6x daily with the total still being 1800mgs a day, I felt a difference, placebo maybe, but I sincerely doubt it.
Is there any way a pharmaceutical company could do a new study regarding the bioavailability of gabapentin so I could better understand this weird wonder drug, it perplexes me that so many people take it, but no one is debating about the bioavailability differences between different dosing regimens. I'm aware there wouldn't be money to be made in doing this study, but I want to know what the deal is. Am I right or is the psychopharmacology expert correct, everything I've read leads me to conclude there is much we don't know and I'm more correct regarding the AUC issue.
Pardon the length of this.
Gabapentin is regularly used, whether as a placebo or not, to treat seizures, anxiety, and nerve/neuropathic pain. I'd say many patients find gabapentin useful and would continue its use even if for some reason they had to pay out of pocket for the prescription. This says something in a world of pharmaceuticals that don't really do much of anything perceived as helpful or curative/palliative by patients. Gabapentin is not magical, but it happens to be more useful than many other drugs.
I've heard of people taking massive quantities in an effort to get high and failing miserably, sure its nice, but given what we know about its pharmacokinetics, taking a massive dosage all at once is naive and relatively pointless in the scheme of drug use. I've also seen people post around the web about their addictions to gabapentin, these reports I find rather odd as people are still taking about 3grams at a time
hoping get high, squandering massive prescriptions in a matter of days. I am an addict, the addiction part I get, but the large doses are just a waste of a good pharmaceutical, you would think people might learn. This is a moot point and I will now move on.
I had the good fortune of meeting with the psychopharmacology expert for both The Menninger Clinic and Mclean Hospital this year. I will state bluntly that Mcleans psychopharmacology expert is clearly an avid textbook connoisseur and I congratulate him on his ability to read and regurgitate medical books; boring guy, relatively unhelpful, didn't tell me anything I wasn't already aware of. The psychopharmacology expert for The Menniger Clinic was very personable and I enjoyed my debate with him over the efficacy of different dosing regiments of gabapentin. I know that the human body can only utilize so much gabapentin at one time. Besides using snacks and Aleve to potentiate it, the body seems to put to use about 200mg of a 300mg capsule give or take every 45 minutes to 90 minutes. More can be squeezed through by increasing bioavailability or taking mass doses, this is generally a waste of gabapentin though. Ultimately the stance of the Menninger psychopharm expert was that the area under the curve was the same dosed at 600mg 3x daily or 300mg 6x daily. I couldn't resolve the area under the curve issue with him, I am sure the AUC for gabapentin must be higher if dosed more often if the daily total dosage is the same. My psychopharmacologist when i was at Austen Riggs declined to comment on the matter, so be it. My outpatient psychiatrist let me switch my dosing from 3x daily to 6x daily with the total still being 1800mgs a day, I felt a difference, placebo maybe, but I sincerely doubt it.
Is there any way a pharmaceutical company could do a new study regarding the bioavailability of gabapentin so I could better understand this weird wonder drug, it perplexes me that so many people take it, but no one is debating about the bioavailability differences between different dosing regimens. I'm aware there wouldn't be money to be made in doing this study, but I want to know what the deal is. Am I right or is the psychopharmacology expert correct, everything I've read leads me to conclude there is much we don't know and I'm more correct regarding the AUC issue.
Pardon the length of this.