Ham-milton
Bluelighter
- Joined
- Jul 20, 2007
- Messages
- 5,738
I was looking for any new information about how gabapentin works, and I came across this article about XP12512.
As I'm sure many are aware, Gabapentin itself is poorly absorbed, and as you take more and more, the percentage absorbed is less and less.
The researchers got around that by creating a prodrug designed for optimal absorption and named it XP13512. I've decided that whoever sells it is gonna name it Pronrontin, so that's what I'm gonna call it here.
Anyway, Gabapentin itself is virtually impossible to overdose on- a 32 gram overdoser managed to live and tell the tale with (fairly) minimal support from the ER. I don't think he was even put on a ventilator.
Will Pronrontin maintain this, or do you suppose the inability to die from it is directly related to the inability of the body to absorb it?
Will Pronrontin have a quicker method of action? I mean, neurontin takes about 2 hours to kick in at all, do you suppose that'll be the same or not?
It's pretty interesting, I think most of the problems with gabapentin itself are due to it's pharmacokinetic properties, but this should eliminate many of them, hopefully.
Here's the link: Pronrontin
It does talk about the synthesis at the very begining, though, so I hope I'm not violating policy. The information about the pharmacokinetics are towards the end (maybe halfway through?).
The synthesis, starting from gabapentin is pretty simple, I think. I'm no chemist, but it sounds like the sort of thing anyone with a bottom of neurontin and a handful of chemicals could handle.
As I'm sure many are aware, Gabapentin itself is poorly absorbed, and as you take more and more, the percentage absorbed is less and less.
The researchers got around that by creating a prodrug designed for optimal absorption and named it XP13512. I've decided that whoever sells it is gonna name it Pronrontin, so that's what I'm gonna call it here.
Anyway, Gabapentin itself is virtually impossible to overdose on- a 32 gram overdoser managed to live and tell the tale with (fairly) minimal support from the ER. I don't think he was even put on a ventilator.
Will Pronrontin maintain this, or do you suppose the inability to die from it is directly related to the inability of the body to absorb it?
Will Pronrontin have a quicker method of action? I mean, neurontin takes about 2 hours to kick in at all, do you suppose that'll be the same or not?
It's pretty interesting, I think most of the problems with gabapentin itself are due to it's pharmacokinetic properties, but this should eliminate many of them, hopefully.
Here's the link: Pronrontin
It does talk about the synthesis at the very begining, though, so I hope I'm not violating policy. The information about the pharmacokinetics are towards the end (maybe halfway through?).
The synthesis, starting from gabapentin is pretty simple, I think. I'm no chemist, but it sounds like the sort of thing anyone with a bottom of neurontin and a handful of chemicals could handle.
