N&PD Moderators: Skorpio | someguyontheinternet
Dope_User said:gotta go shovel snow (expected up to 2 FEET in Northern NJ) so I'll edit this is a a bit.
5-HT2 said:[VERY USEFUL AND INFORMATIVE STATEMENTS REMOVED BY A STUPID PARANOID MODERATOR]
Thanks again 5-HT2
who mE? said:Not to hijack the thread, but Ketamine is widely reported to bind to Kappa opioid receptors, and there are several reports of mu-agonism... Please do a search for a thread titled "Ketamine the Opioid" in Other Drugs by myself.
I also personally find GHB and its analogues EXTREMELY euphoric (on par with MDMA or oxycodone), and read several abstracts on The Hive (R.I.P.) regarding the idea that its euphoria was GABA-B mediated.
Several reputable sources say that the "GHB receptor" is dysphoric and is pro-convulsant
I would LOVE to personally taste test a non-toxic GABA-B agonist, because I think it might just be my idea of "the perfect drug".
BilZ0r said:The molecular identy of the GHB is known. PMID 12958178
Still, I'm very dubious of this idea that the GHB receptor is dysphoric, or more, that its part to play in GHBs effect is pointless... anyone who says that, needs to compare baclofen to GHB, and it will be blatently obvious. Sure some people find baclofen a little fun, but it's not GHB.
But isn't GHBs "pro-seizure" effect ... I mean, it's absence seizure, not tonic-clonic seizures....
baclofen does the same thing.
Anyway, as far as this whole, ketamine opioid thing goes, as far as I'm awear, there is only one study which looks at that (here), now I would have liked it if they had done the experiment and shown a negative result.. "Racemic ketamine inhibited the formation of cyclic adenosine monophosphate (naloxone insensitive) in a dose-dependent manner (concentration producing 50% inhibition approximately 2 mM) in all cell lines, including untransfected CHO cells" makes me very nervous. Finally, even if we assume they are correct, these affinities are around 40, 30, 270µM (mu, kappa, delta) respectively, in comparison to its 900nM NMDA affinity... i.e. they're about 100x too weak. [/B]
Does baclofen do the same thing as GHB? I don't think it is widely (if at all) used to pharmacologically model absence.