Opioids FDA warns about serious blood disorder resulting from misuse of Opana ER

[endotropic]

I didn't see this posted yet but feel free to close if this is already up somewhere else.


FDA warns about serious blood disorder resulting from misuse of Opana ER

[10-11-2012] The U.S. Food and Drug Administration (FDA) recently became aware of cases of a serious blood disorder that occurred in individuals abusing the prescription pain medicine Opana ER (oxymorphone hydrochloride extended-release tablets) by injecting the drug into their bloodstream. This serious blood disorder, called thrombotic thrombocytopenic purpura (TTP), resulted in kidney failure requiring dialysis in some cases, and at least one death.

In TTP, blood clots form in small blood vessels throughout the body. The clots can limit or block blood flow to the body’s organs, such as the kidneys, brain, and heart. Certain blood cells called platelets help the blood to clot. In TTP, as platelets clump together in the blood clots, fewer platelets are available in the blood in other parts of the body to help with clotting there. This can lead to bleeding under the skin and purple-colored spots called purpura, or to bleeding inside the body. TTP can cause death or lead to other complications with permanent damage, such as kidney failure, brain damage, or stroke.

TTP appears to occur with Opana ER only when it is abused and injected intravenously. Opana ER is meant to be taken orally, and should only be taken when prescribed and as directed. Taking it any other way may result in serious adverse events, including death.

http://www.fda.gov/Drugs/DrugSafety/ucm322432.htm

No mention of the number of cases or whether users were filtering their injections in any way. Still something to be aware of.

 

[chase_in_56ace]

I wonder if fools like myself that recklessly inject roxies can add this onto our list of risks.

 

[tricomb]

This is basically one of the consequences of mainlining a solution that is contaminated by binders and fillers, especially when the solution has been heated.


Thanks for sharing this endotropic.

 

[bayhead415]

I see no mention of whether it is the Intac or timerx formula... If anyone figure this out update for sure.

 

[tricomb]

^I'm sure it's both. The time release mechanisms may be different, but that doesn't change the issue of injecting particles that are not supposed to be injected.

 

[bayhead415]

I am not saying one is better to inject than other, but it would be good to know as the intac and timerx are a different formula for the most part. It would be good to know so people know if they should get checked if they filtered timerx after iso extracting or if this only applies to people who where desperate enough to try injecting the intac probably by soaking, filtering, and shooting. Either way good to know so no one tried to inject the ER.... I hope that this has not happened because of the opana solution that is sold on the road... That would REALLY suck for that person.

 

[pbuilder]

Pretty fucked up that they spent so much time making these "abuse-able pills", completely "un-abuse-able" because so many people were getting addicted to them and there were some overdoses reported from abusing them, yet now their "new revolutionary tamper-proof extended release formula" is killing the people addicted to the old version anyways and likely at a faster rate because most addicts know their limit to at least an extent so they can make their risk of overdose very low by always being with a good friend and knowing their limits, so they can abuse the opiates with at least some safety. Instead they will die because the new pharmabrand had dangerous chemicals in them that can kill anyone at an equal percent, because the consumer trusts pharmaceutical drugs to be safe to an extent because they know what they are getting.

 

[Jktm]

The types/amounts of polymers probably does have a lot to do with it, but I could see it getting caused by both formulations for sure.

 

[Coraline]

All opiates reduce white blood cells. They can leave you immuno compromised that in chemically related and not Aids related.

If you stop using opiates your immune system returns to normal.

As gor binder and fillers I'm sure they clog your kidneys up pretty bad. Your kidneys filter like 5 liters of blood every hr.

 

[Jktm]

Your kidneys filter like 5 liters of blood every hr.

So basically all of the blood in your body lol.

 

[Coraline]

So basically all of the blood in your body lol.

Yes. Every hr. lol!!

Don't forget about all the fluids you drink too. Your body has to keep homeostasis. If you drink or eat a lot of salt and have little potassium your body will retain salt and lose the potasium. The kidneys are weird. They also have adrenaline glands attached to them. That can release hormones that give you panic attacks.

 

[Captain.Heroin]

I'm glad this has been shared with the community.

I get the sense this is happening due to people not filtering with a micron filter, but regardless, I wouldn't inject Opana ER tablets whatsoever because of this.

 

[bayhead415]

This should be stickied for harm reduction sake... At least for a short amount of time while the news is fresh in case there are any updated.

 

[tricomb]

This should be stickied for harm reduction sake... At least for a short amount of time while the news is fresh in case there are any updated.

you're such a backseat moderator

I guess it's good that the FDA released something about this, but this is just news confirming what we already suspected and have been trying to warn people about for a while.

 

[bayhead415]

you're such a backseat moderator

I guess it's good that the FDA released something about this, but this is just news confirming what we already suspected and have been trying to warn people about for a while.

Hehe you called it... Doing the work without having to deal with the responsibility... Still I think an FDA warning of a specific issue on shooting certain pills would convince people to not shoot those pills moreso than just general warning that is essentially common knowledge.

 

[tricomb]

Making suggestions aint doin work lol

 

[-Guido-]

Pretty fucked up that they spent so much time making these "abuse-able pills", completely "un-abuse-able" because so many people were getting addicted to them and there were some overdoses reported from abusing them, yet now their "new revolutionary tamper-proof extended release formula" is killing the people addicted to the old version anyways and likely at a faster rate because most addicts know their limit to at least an extent so they can make their risk of overdose very low by always being with a good friend and knowing their limits, so they can abuse the opiates with at least some safety. Instead they will die because the new pharmabrand had dangerous chemicals in them that can kill anyone at an equal percent, because the consumer trusts pharmaceutical drugs to be safe to an extent because they know what they are getting.

They were never intended to be injected. Pills should never be injected.

People dying is a shame but it's there own fault, not the the drug companies.

 

[tentram]

^ not only that. they succeeded in their intent to devise a formulation to certainly deter IV use. those who are still willing to do so at their own risk now knowing the consequences. if they decide to still go ahead, that's their prerogative. and they've no one to blame bar themselves for the consequential harm done.

 

[sterling77]

I am not saying one is better to inject than other, but it would be good to know as the intac and timerx are a different formula for the most part. It would be good to know so people know if they should get checked if they filtered timerx after iso extracting or if this only applies to people who where desperate enough to try injecting the intac probably by soaking, filtering, and shooting. Either way good to know so no one tried to inject the ER.... I hope that this has not happened because of the opana solution that is sold on the road... That would REALLY suck for that person.

------Public Service Announcement------- Concerns Impax/Global Pharm Generic Oxymorphone

This is a good point here. I am not 100% positive with what I am about to propose, but I believe there is a new ingredient that is responsible. If I am right, this poses a possible problem because people with the new crushable generics will think they are good to go, and the problems are due to some crazy crisping method used on the un-crushable Endo Opanas.

I believe the culprit here may be partially hydrolyzed Poly Vinyl Alcohol (PVA). This ingredient is common to both the tamper-resistant Endo Opana, and the new Impax/Global Pharm generics. Since it is partially hydrolyzed I believe the PVA's present may be of the high molecular weight variety. This ingredient *IS* WATER SOLUBLE, meaning it will even pass through a micron filter in cold water. It can cause anemia, proteinuria, kidney failure, hepatic failure, clotting issues, fever, chills, embolism, vascular lesions, spleen issues, etc. It can aggregate in organs such as the liver, spleen, brain.

Intravenous use in humans is not too well studied (as far as I can tell), but it is sometimes used in medicine for embolization of abnormal tissues. If anyone has been injecting the new Impax/Global Pharm generics, please post here if you have or have not been having any symptoms or side effects. I may be wrong here, and I hope that is the case. I would like everyone doing these to be on the lookout just in case.

 

[down508]

I see opana as being a huge problem in the near future. the extremely low oral bioavailability spells disaster when people start injecting the pills. and I've posted about this before, but I'll say it here: pharm companys aren't motivated to reformulate to make their drugs safer, they do it for financial reasons. I don't know the spefics about opana but I do know that when a drugs patent runs out the pharm company will do anything in their power to change the drug and get a new patent. look at suboxone strips, look at suboxone in general. there's a reason why doctors love to prescribe suboxone over subutex, and it's not because the naloxone deters abuse.