Ekscentra
Bluelighter
- Joined
- Feb 20, 2014
- Messages
- 53
Hey,
I haven't found any information on the following, so I decided to create a new thread hoping to get some valuable input here. Yes, I've done both a thread search here and a custom search on Google for the Bluelight forum. Neither of these two methods yielded any useful results, nor did scouring every single drug-related forum on the internet. It seems as though the information simply doesn't exist at the moment. So here goes: I suppose I'll be the first to try and get some information on this topic.
So I've have a bit of a problem with dissociatives lately. At some point, usually a couple hours after dosing, both DXM and MXE cause my sebum production to go crazy. My fingertips are ridiculously greasy, as are parts of my face. I assume this is due to the possible opioidergic effect of MXE and the sigma agonism causing a boost in endogenous opiates for both substances, correct?
I very much enjoy my dissociatives, but this side effect is incredibly annoying and although it was tolerable the first dozen or so times it occurred (strangely enough, I didn't experience this early on with either substance), I'm getting to the point where I'm considering stopping my dissociative use entirely until I can deal with this problem. These substances have been very useful for me in many ways, so it would be a real shame to have to let them go. I'm not going to let that happen until I've expended all viable options first, within a reasonable safety limit, for me that is. This means anything less dangerous than most halogenated amphetamines and nearly all solvents (along with a few other exceptions), so long as the effects look unique and interesting enough, are on the table. Since this topic is about dissociatives, yes, this includes Dizocilpine and possibly both Diphenidine and Methoxphenidine so long as they don't have anything more than a negligible action on the sigma receptors. Being related to MK-801, it's a moderately high possibility that both of these substances fit the criteria I need here.
The first option, and I'm not even sure if this will work to antagonize sigma but nonetheless, I'll mention it anyways: combining a dissociative with Naltrexone (ideally) or Naloxone should block at least some of the negative effects of the former substance on the skin. If anyone has any experience with combining dissociatives and opioid antagonists, please do chime in. Hopefully this combination won't end up causing dysphoria like I expect it to, and instead will only get rid of the effects opioids have on skin. That would be ideal for me. 3-MeO-PCP would likely be my DOC for this combination, as it seems to have the most desirable balance of effects, and it would likely be perfect for functional use, even at moderate doses.
The second option is to find an NMDA antagonist that does not agonize sigma receptors in the first place, eliminating the need for additional substances to reduce or eliminate the side-effects. While there are only a few substances at most that fall into this category, it shouldn't be too difficult to obtain at least one of them. If this option does end up being taken, Dizocilpine is certainly one I'm more than willing to indulge in. I'm more than aware of the supposed dangers, yet I still have a strong desire to try this one. I have yet to read a single report on even suspected lasting mental damage (that was from someone who actually tried the substance), and I may or may not remember reading one that alluded to possible temporary physical damage, of which I'd have to say it seems slightly more dangerous than Ketamine in this aspect, from my own subjective evaluation, but not so much so that I wouldn't consider using it. The bleeding stool report many users mention was that of a user who dosed *far* in excess of anything that could remotely be considered reasonable and at very irresponsible frequencies, and he even admitted his own stupidity in the same line the side-effect was mentioned. Given this, the true damage infrequent dosing is capable of is a complete toss-up. Most, I'm sure, would lean towards severe danger, but given the evidence we currently have (of which we certainly could use some more), I'd say it's only mildly to moderately dangerous at worst, and using frequent low doses shouldn't be a problem. I wouldn't recommend anyone go out and use this stuff despite having said that, as it is still unknown just how much damage you could be doing to yourself, but I have no reservations trying this substance myself considering the anecdotal evidence available.
If anyone knows of any other NMDA antagonists that do not effect the sigma receptor, or that have an affinity below the threshold of any perceivable effects from sigma, I'd highly appreciate it. So far, Dizocilpine has been my only find, though I admit I haven't done nearly enough research on this exact matter yet. Still, I would certainly consider using Dizocilpine at an incredibly low dose, 50-100mcg per day or likely even lower than that, once per day to ward off tolerance from whatever other substances I happen to be using at the time. It may be an incredibly confusing substance for some, causing a profound loss in memory, but it's still an NMDA antagonist, so I have no reason not to believe at *some* point the dose will be low enough to aid with functional uses. We (or I, more likely) just have to find out what that dose is. Still, I'd prefer the first option, if only because 3-MeO-PCP just looks interesting as hell, and not just for some massively crazy novel effects like what Dizocilpine seems to do to users. Rather, 3-MeO-PCP looks both incredibly fun, excellent for nootropic and other functional purposes (or at least not counter-productive in most nootropic stacks), and with surprisingly little to no lasting negative effects reported with long-term 10mg per day dosing, in one report I had previously read. Considering I may dose even lower and take weekends off all substances, this makes 3-MeO-PCP even more attractive to me.
Once again, if anyone has any experience combining Naltrexone or Naloxone with a sigma-agonizing dissociative, I'd very much like to know about it. Thanks in advance for any future contributions, folks, and I hope you all have a nice day.
I haven't found any information on the following, so I decided to create a new thread hoping to get some valuable input here. Yes, I've done both a thread search here and a custom search on Google for the Bluelight forum. Neither of these two methods yielded any useful results, nor did scouring every single drug-related forum on the internet. It seems as though the information simply doesn't exist at the moment. So here goes: I suppose I'll be the first to try and get some information on this topic.
So I've have a bit of a problem with dissociatives lately. At some point, usually a couple hours after dosing, both DXM and MXE cause my sebum production to go crazy. My fingertips are ridiculously greasy, as are parts of my face. I assume this is due to the possible opioidergic effect of MXE and the sigma agonism causing a boost in endogenous opiates for both substances, correct?
I very much enjoy my dissociatives, but this side effect is incredibly annoying and although it was tolerable the first dozen or so times it occurred (strangely enough, I didn't experience this early on with either substance), I'm getting to the point where I'm considering stopping my dissociative use entirely until I can deal with this problem. These substances have been very useful for me in many ways, so it would be a real shame to have to let them go. I'm not going to let that happen until I've expended all viable options first, within a reasonable safety limit, for me that is. This means anything less dangerous than most halogenated amphetamines and nearly all solvents (along with a few other exceptions), so long as the effects look unique and interesting enough, are on the table. Since this topic is about dissociatives, yes, this includes Dizocilpine and possibly both Diphenidine and Methoxphenidine so long as they don't have anything more than a negligible action on the sigma receptors. Being related to MK-801, it's a moderately high possibility that both of these substances fit the criteria I need here.
The first option, and I'm not even sure if this will work to antagonize sigma but nonetheless, I'll mention it anyways: combining a dissociative with Naltrexone (ideally) or Naloxone should block at least some of the negative effects of the former substance on the skin. If anyone has any experience with combining dissociatives and opioid antagonists, please do chime in. Hopefully this combination won't end up causing dysphoria like I expect it to, and instead will only get rid of the effects opioids have on skin. That would be ideal for me. 3-MeO-PCP would likely be my DOC for this combination, as it seems to have the most desirable balance of effects, and it would likely be perfect for functional use, even at moderate doses.
The second option is to find an NMDA antagonist that does not agonize sigma receptors in the first place, eliminating the need for additional substances to reduce or eliminate the side-effects. While there are only a few substances at most that fall into this category, it shouldn't be too difficult to obtain at least one of them. If this option does end up being taken, Dizocilpine is certainly one I'm more than willing to indulge in. I'm more than aware of the supposed dangers, yet I still have a strong desire to try this one. I have yet to read a single report on even suspected lasting mental damage (that was from someone who actually tried the substance), and I may or may not remember reading one that alluded to possible temporary physical damage, of which I'd have to say it seems slightly more dangerous than Ketamine in this aspect, from my own subjective evaluation, but not so much so that I wouldn't consider using it. The bleeding stool report many users mention was that of a user who dosed *far* in excess of anything that could remotely be considered reasonable and at very irresponsible frequencies, and he even admitted his own stupidity in the same line the side-effect was mentioned. Given this, the true damage infrequent dosing is capable of is a complete toss-up. Most, I'm sure, would lean towards severe danger, but given the evidence we currently have (of which we certainly could use some more), I'd say it's only mildly to moderately dangerous at worst, and using frequent low doses shouldn't be a problem. I wouldn't recommend anyone go out and use this stuff despite having said that, as it is still unknown just how much damage you could be doing to yourself, but I have no reservations trying this substance myself considering the anecdotal evidence available.
If anyone knows of any other NMDA antagonists that do not effect the sigma receptor, or that have an affinity below the threshold of any perceivable effects from sigma, I'd highly appreciate it. So far, Dizocilpine has been my only find, though I admit I haven't done nearly enough research on this exact matter yet. Still, I would certainly consider using Dizocilpine at an incredibly low dose, 50-100mcg per day or likely even lower than that, once per day to ward off tolerance from whatever other substances I happen to be using at the time. It may be an incredibly confusing substance for some, causing a profound loss in memory, but it's still an NMDA antagonist, so I have no reason not to believe at *some* point the dose will be low enough to aid with functional uses. We (or I, more likely) just have to find out what that dose is. Still, I'd prefer the first option, if only because 3-MeO-PCP just looks interesting as hell, and not just for some massively crazy novel effects like what Dizocilpine seems to do to users. Rather, 3-MeO-PCP looks both incredibly fun, excellent for nootropic and other functional purposes (or at least not counter-productive in most nootropic stacks), and with surprisingly little to no lasting negative effects reported with long-term 10mg per day dosing, in one report I had previously read. Considering I may dose even lower and take weekends off all substances, this makes 3-MeO-PCP even more attractive to me.
Once again, if anyone has any experience combining Naltrexone or Naloxone with a sigma-agonizing dissociative, I'd very much like to know about it. Thanks in advance for any future contributions, folks, and I hope you all have a nice day.
