Etyhlphenidate

[BothHands]

I recently found this chemical on a vendor website, which led me to do a bit of research. Turns out if you have methylphenidate (which is extremely easy to get), you can make your own my coingesting it with ethanol. Much like coingesting cocaine with ethanol produces cocaethylene.

I'm enormously intoxicated, so forgive me if I have trouble organizing my thoughts.

But some background: I'm incredibly sensitive to stimulants, and even half a cup of coffee causes me to become extremely anxious and I get severe jitters. I think it has something to do with damage caused by the 2 years I was on a 300mg/day seroquel regimine. Stimulants have never been the same for me.

Even when I was prescribed methylphenidate, I never took more than 2.5mg due to shakes, sweats, and anxiety. But even such low doses significantly improved my ability to retain information in class.

But since I discovered that ethlyphenidate has a very low affinity for the norpinephrine receptors, I've been experimenting with it, and it works amazing. It's stimulation clear anxiety-free stimulation like I've never felt before.

But anyway, here's what I'm here for. I'm looking for some more literature on the chemical. I can't seem to find a whole lot of stuff out there.

What's the half life?

About how much ethanol needs to be taken per mg of methylphenidate for optimum conversion?

Is there a particular enzyme responsible for the conversion? Know of any enzyme inducers for this particular enzyme?

Anything else to add that might be helpful?

Thanks!

 

[atara]

Ethylphenidate is the closest thing to a pure DRI ever to show up on any sort of drug market. I'm kind of interested in trying it.

I, like you, was once prescribed methylphenidate, though I took 30 mg / day and it was still not as effective as the doctors would have liked. I'm not really sensitive to stimulants...

Also, consuming ethanol with methylphenidate does produce some ethylphenidate in vivo; however, this is not an efficient way of consuming ethylphenidate! Methylphenidate is significantly more potent than ethylphenidate, and so the experience will be dominated by the effects of methylphenidate. It's the opposite of cocaethylene, which is more potent than ordinary cocaine (and so combining cocaine and alcohol will effectively produce cocaethylene intoxication).

 

[Transform]

Perhaps it's just the alcohol which is calming the anxiety, as opposed to an effect from any conversion to EPH?

 

[adder]

This conversion is enantioselective, no appreciable amounts of active isomer of methylphenidate are converted.

 

[sekio]

Perhaps it's just the alcohol which is calming the anxiety, as opposed to an effect from any conversion to EPH?

I think this is the most likely case.

 

[Wizzle]

IME ethanol potentiates methylphenidate, so I'd say adder is right.. I'll get symptoms like jaw clenching when taking my normal dose with a moderately high amount of ethanol (At least 6 six drinks)

 

[negrogesic]

I thought ethylphenidate had stronger NE uptake-inhb? I haven't seen the binding data, but from what i vaguely recall from some methylphenidate SAR study..........

Personally, however, i do not think ethanol and MPH gives an accurate representation of pure ethylphenidate, simply due to the profound CNS activity of ethanol....

 

[atara]

http://en.wikipedia.org/wiki/Ethylphenidate

http://journals.lww.com/behavioural...=2007&issue=02000&article=00005&type=abstract

Ethylphenidate has 10x selectivity for DAT over NET. Pretty good, I'd say.

 

[BothHands]

Perhaps it's just the alcohol which is calming the anxiety, as opposed to an effect from any conversion to EPH?

Alcohol doesn't cause a reduction in caffeine induced anxiety/jitters, which leads me to believe there is something else going on.

This conversion is enantioselective, no appreciable amounts of active isomer of methylphenidate are converted.

Want to explain further? I'm not exactly a chemistry expert, but you're saying the conversion produces far more of the inactive l-isomer than the active d-isomer, right? I guess this could be partially responsible for the reduction in anxiety - there's a reduction in total active chemical. But I still feel significant stimulation.

Do you have any literature on the amounts of each isomer produced? I have a feeling that the levels of the d-isomer are not negligible. But placebo is a powerful thing.

Thanks for the help guys. Anyone have anything else to add?

 

[negrogesic]

^^^have you tried d-MPH (focalin)..............it is feels subjectively far superior than the racemate, not in terms of potency, but qualitatively superior.....

Than are many specific potent to ultra potent specific DRIs.......but, I personally believe these drugs must be well rounded (like cocaine) for maximum "recreational" potential. Sure, the self-admin can be high with these compounds. But, if you give a very DAT specific compound to a experienced coke-head, they may keep on using it, but it doesn't fully sub for cocaine...

More to the point........many compounds will get you wired, alert, buzzed, talkative, anxiolytic-anxiogenic (d-MPH, particular moderate intranasal doses, initially produce anxiolysis, and further redosing/comedown become eventually anxiogenic and in time, psychotomimetic). They will and do make one feel "uplifted", can positively modulate mood, reduce appetite and have you redosing like a fiend.......but in the end.....do they really get you" high?

There is a compound that I've only seen administered, an r-labeled DRI of greater potency called" "DatSCAN", and I've never heard of any abuse by healthcare workers. Furthermore, I never say patients appear particular high after imaging, though these are neurologically impaired individuals.

Point being, finally, is that the dopamine-reward mechanism is, while well documented in countless elaborate studies, does NOT entirely explain the phenomena in humans. Cocaine studies in particular have hampered on the dopaminergic role of this compounds abuse. Some more progressive and newer studies show the flaws in this ultra-narrow focus.

There is a reason why a drug like cocaine, produced exclusively in one remote corner of the world, can be found in any major city on EARTH. It is a good drug, a unique drug, and is not easily replicated. Cocaine users have been know to continually use the drug even after given anti-psychotic agents (the best "anti-cocaine" agent in my opinion is seroquel).

I think 4-iodo MPH, from what I vaguely recall, has some interesting SERT affinity, but still, not nearly as well balances as cocaine...........

 

[mad_scientist]

There is a compound that I've only seen administered, an r-labeled DRI of greater potency called" "DatSCAN", and I've never heard of any abuse by healthcare workers. Furthermore, I never say patients appear particular high after imaging, though these are neurologically impaired individuals.

The dose probably isn't high enough; from the prescribing information the largest dose that would be administered to a patient would be around 0.65ug of ioflupane, and it says explicitly "Due to the low quantities of ioflupane injected, pharmacological effects are not expected following intravenous administration of DaTSCAN at the recommended dosage."

Even the stronger phenyltropanes have an active dose of a few milligrams at least, so most likely it would take numerous vials of DatSCAN before any stimulant effects are apparent, especially as it has a short duration so even taking lots of vials over an extended period wouldn't be any stronger, it would have to be all at once. They note that pharmacological (i.e. stimulant) effects were noted in the animal toxicity studies, but these were at some 6500x the maximum dose used in humans - and on a bodyweight basis would correspond to a dose of around 4mg of ioflupane, which is about what you would expect for an active dose in humans. The radiation exposure from taking this much of the radiolabelled commercial DatSCAN product probably would be quite bad for you I'd imagine...

 

[negrogesic]

Exactly, even the techs know not to mess with this r-labeled drug.........

The larger point........DAT specific drugs are certainly, interesting, but hyperfocus on dopaminergic qualties of compounds without a "broader" perspective is, on a qualitatively recreational basis, narrow minded.

And, given its relative prevalence (DatSCAN), some moron, along the way, got ahold of enough of the compound to get high, and perhaps develop some carcinoma years later.........Healthcare professionals are fiends...........but, most perioperative physicians are able to keeo their hand out of the "cookie jar".....

 

[adder]

Alcohol doesn't cause a reduction in caffeine induced anxiety/jitters, which leads me to believe there is something else going on.

Alcohol doesn't reduce anxiety by any means. It may happen at very low doses but it makes your heart beat faster and other symptoms appearing rather show that it's subjectively stimulating at doses one doesn't lose consciousness. Also, euphoria from alcohol weak intoxication is gone once more is ingested and mood gets labile. And when we're dealing with an overdose, i.e. a state in which an intoxicated person vomits, panic attacks are very probable. Alcohol more often will cause anxiety than reduce it. It has too many targets in CNS for its depressing action to be subjectively felt as an anxiolytic at doses people experience some short-lasting euphoria.

 

[ebola?]

There is a compound that I've only seen administered, an r-labeled DRI of greater potency called" "DatSCAN", and I've never heard of any abuse by healthcare workers.

ebola

 

[Kilfer]

Ethylphenidate is the closest thing to a pure DRI ever to show up on any sort of drug market.

The birth of a God. Hard to imagine that RC's biggest hit ever is barely two years old but then, how often do RC's promising chemical structure as cocaine-like substances actually do deliver the goods? And this one's structure is not really close to cocaine's, at least not in this lowly amateur's eye, and yet... Not really coke but the best widely available substitute IMHO.

Methylphenidate is significantly more potent than ethylphenidate[..]

So were we led to believe indeed. But the reality was so different it's even hard to compare EPH with MPH other than on a chemical structure base.