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Etoxadrol and Dexoxadrol

Unlike PCP/Ketamine they have no FX@dopamine receptors not sure about sigma tho(altho i think not), altho no one still knows what sigma agonists do yet or how it would effect the trip. I still think pure NMDA antagonists will still be fun but perhaps not as fun as the classical mixed FX dissociatives. I'm still tryin to get my hands on some MK801, a synth of "proxadrol" is in the works in where the ethyl of etoxadrol is replaced by a propyl, the bigger alkyl is the more potent it is, this would make it closer to the potency of TCP.
 
should call it propoxadrol, better ring to it.

Why not switch it with dodecyl? Are you sure that it continues to increase from doxoxadrol to etoxadrol to propoxadrol? Ethyl could easily be the most potent. Amphetamine obviously increases potency from ethyl to propyl, but it stops there. alpha-ethyl-pea (the butyl amine amp analogue.

It seems that for NMDA antagonists to be well accepted, they need to have some additional activity- DAT inhibition, opioid affinity, etc, and a relatively short duration. They're too intoxicating to enjoy for eight hours.
 
true, the initial trip is fun but gets scary if it lasts to long, PCP is cool cuz the after effects are amazing, like a whole nother drug/high itself. People like n2o, even tho its real short it has no opiate/dopamine/sigma fx, altho i don't care for it, mk801 trips still sound fun(to me).

I think the most potent of the etoxadrol analogs had a 1-chloroalkyl, but it is a rule with etoxadrol analogs that the heavier the alkyl the more potent which is different than most drugs i know of.
 
eople like n2o, even tho its real short it has no opiate/dopamine/sigma fx
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But that's not true. It definitely has some sort of effect on opioid receptors. I believe it also causes mild DAT inhibition.
 
"irreversible inhibitor at PCP site" I stopped reading right there. Someone who's not typing this on a phone from work should dig up some binding assays.
But, just with that first bit I wouldn't want to mess around with it.
 
Epsilon Alpha said:
"irreversible inhibitor at PCP site" I stopped reading right there. Someone who's not typing this on a phone from work should dig up some binding assays.
But, just with that first bit I wouldn't want to mess around with it.
Click to expand...

I doubt this. Having tried dexoxadrol, it didn't do anything insane. Wasn't particularly fun, but no unexpected reactions for an NMDA antagonist. And considering etoxadrol has an ethyl substituted for the phenyl, it's not exactly introducing any reactive groups that would be prone to irreversible binding.

Also, the second reference for that statement on wikipedia says nothing about irreversible binding. Can't get the full text on the first though.
 
It's not an irreversable NMDA blocker, it works by the same mechanism as PCP

duration of effects is very strongly correlated to dose though, from what I've read (again like PCP)
 
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