dilated_pupils
Bluelighter
The Basics:
Intro and basic description:
Etizolam is a benzodiazepine analog. The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring, making the drug a thienodiazepine.
Timeline of Experience:
Onset: 10-35 minutes
Peak: 1.5 hrs-2.3hrs
Plateau: 1-2 hours
Afterglow: 1-5 hours (depending on reason of use - anxiety relief/recreation etc.)
Baseline: 12-14hrs after use
Effects:
The effects of etizolam compare to those of the benzodiazepine class of drugs such as diazepam, lorazepam, and alprozolam. As such other drugs it includes amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.
Dosages:
Oral: .5mgs to 2mgs for anxiety relief
Method Of Administration:
Oral
Slang:
Etilaam; Etizola; Etizest; Sedekopan; Arophalm; Depas; Pasaden *cited from https://www.erowid.org/pharms/etizolam/
Contraindictions and Overdose:
Like benzodiazepines, the possibility of blacking out (similar to alcohol and increased when alcohol is mixed with these types of drugs) is possible from a non-tolerant user, or someone who neglects the potency of said chemicals and misuses the drug or accidently overdoses due to having the chemical in powder form. People have been known to re-dose to quickly, as well as re-dose while blacked out, and end up in situations where their motor skills are needed such as driving and end up in an accident.
Make sure to watch out for such adverse reactions, it's always good to know your dose, and stick to it. Having someone close by for your first initial tests may provide a safety net from you and an accidental overdose or an accident. Do not drive while impaired, no matter what!
Itraconazole and fluvoxamine slow down the rate of elimination of etizolam, leading to accumulation of etizolam, therefore increasing its pharmacological effects.[24][25] Carbamazepine speeds up the metabolism of etizolam, resulting in reduced pharmacological effects.[26]
Etizolam, similarly to other GABAergic agonists including the benzodiazepines has a strong synergistic effect with ethanol and the consequences of co-ingestion of the two drugs can drastically compound the side effects of either drug. This can result in (among other effects) anterograde amnesia (blackouts) and severe respiratory depression which in extreme cases can lead to death.***
Neg. Short-Term Side effects: short term memory loss
Negative Long-term side effects:
Possible tolerance build up after prolonged use.
Addiction and withdrawal issues: Abrupt or rapid withdrawal from etizolam, as with benzodiazepines, may result in the appearance of the benzodiazepine withdrawal syndrome, including rebound insomnia.[9] Neuroleptic malignant syndrome, a rare event in benzodiazepine withdrawal, has been documented in a case of abrupt withdrawal from etizolam. Elderly patients should start on a lower dose as they are more susceptible to the sedative effects of etizolam. It is not recommended to be taken during pregnancy or breastfeeding. However, Etizolam has been shown to have a reduced liability to induce tolerance, and dependence, compared with classical benzodiazepines [When multiple doses of etizolam, or lorazepam, were administered to rat neurons, lorazepam caused downregulation of alpha-1 benzodiazepine binding sites (tolerance/dependence), while etizolam caused an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects).[13] Tolerance to the anticonvulsant effects of lorazepam were observed, but no significant tolerance to the anticonvulsant effects of etizolam were observed.] *cited from http://en.wikipedia.org/wiki/Etizolam
Harm Reduction:
Watch out for re-dosing, as the effects may be nil and quickly become overpowering. Blackouts may occur, and for those prone to such occurrances, please use special caution when dosing and always alert someone if you're using said substances. This will help prevent black outs and from re-dosing on blackouts/driving while blacked out.
Legal Issues:
None currently, as Etizolam remains unscheduled.
Background and Chemistry:
History of Drug:
Chemistry:
Pharmacology:
Preparation:
Mechanism of Action:
Trip reports and links:
Trip reports: https://www.erowid.org/experiences/subs/exp_Etizolam.shtml
Links: https://www.erowid.org/pharms/etizolam/
Category: Drugs FAQS [Category: Thienodiazepines]
Intro and basic description:
Etizolam is a benzodiazepine analog. The etizolam molecule differs from a benzodiazepine in that the benzene ring has been replaced by a thiophene ring, making the drug a thienodiazepine.
Timeline of Experience:
Onset: 10-35 minutes
Peak: 1.5 hrs-2.3hrs
Plateau: 1-2 hours
Afterglow: 1-5 hours (depending on reason of use - anxiety relief/recreation etc.)
Baseline: 12-14hrs after use
Effects:
The effects of etizolam compare to those of the benzodiazepine class of drugs such as diazepam, lorazepam, and alprozolam. As such other drugs it includes amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.
Dosages:
Oral: .5mgs to 2mgs for anxiety relief
Method Of Administration:
Oral
Slang:
Etilaam; Etizola; Etizest; Sedekopan; Arophalm; Depas; Pasaden *cited from https://www.erowid.org/pharms/etizolam/
Contraindictions and Overdose:
Like benzodiazepines, the possibility of blacking out (similar to alcohol and increased when alcohol is mixed with these types of drugs) is possible from a non-tolerant user, or someone who neglects the potency of said chemicals and misuses the drug or accidently overdoses due to having the chemical in powder form. People have been known to re-dose to quickly, as well as re-dose while blacked out, and end up in situations where their motor skills are needed such as driving and end up in an accident.
Make sure to watch out for such adverse reactions, it's always good to know your dose, and stick to it. Having someone close by for your first initial tests may provide a safety net from you and an accidental overdose or an accident. Do not drive while impaired, no matter what!
Itraconazole and fluvoxamine slow down the rate of elimination of etizolam, leading to accumulation of etizolam, therefore increasing its pharmacological effects.[24][25] Carbamazepine speeds up the metabolism of etizolam, resulting in reduced pharmacological effects.[26]
Etizolam, similarly to other GABAergic agonists including the benzodiazepines has a strong synergistic effect with ethanol and the consequences of co-ingestion of the two drugs can drastically compound the side effects of either drug. This can result in (among other effects) anterograde amnesia (blackouts) and severe respiratory depression which in extreme cases can lead to death.***
Neg. Short-Term Side effects: short term memory loss
Negative Long-term side effects:
Possible tolerance build up after prolonged use.
Addiction and withdrawal issues: Abrupt or rapid withdrawal from etizolam, as with benzodiazepines, may result in the appearance of the benzodiazepine withdrawal syndrome, including rebound insomnia.[9] Neuroleptic malignant syndrome, a rare event in benzodiazepine withdrawal, has been documented in a case of abrupt withdrawal from etizolam. Elderly patients should start on a lower dose as they are more susceptible to the sedative effects of etizolam. It is not recommended to be taken during pregnancy or breastfeeding. However, Etizolam has been shown to have a reduced liability to induce tolerance, and dependence, compared with classical benzodiazepines [When multiple doses of etizolam, or lorazepam, were administered to rat neurons, lorazepam caused downregulation of alpha-1 benzodiazepine binding sites (tolerance/dependence), while etizolam caused an increase in alpha-2 benzodiazepine binding sites (reverse tolerance to anti-anxiety effects).[13] Tolerance to the anticonvulsant effects of lorazepam were observed, but no significant tolerance to the anticonvulsant effects of etizolam were observed.] *cited from http://en.wikipedia.org/wiki/Etizolam
Harm Reduction:
Watch out for re-dosing, as the effects may be nil and quickly become overpowering. Blackouts may occur, and for those prone to such occurrances, please use special caution when dosing and always alert someone if you're using said substances. This will help prevent black outs and from re-dosing on blackouts/driving while blacked out.
Legal Issues:
None currently, as Etizolam remains unscheduled.
Background and Chemistry:
History of Drug:
Chemistry:
Pharmacology:
Preparation:
Mechanism of Action:
Trip reports and links:
Trip reports: https://www.erowid.org/experiences/subs/exp_Etizolam.shtml
Links: https://www.erowid.org/pharms/etizolam/
Category: Drugs FAQS [Category: Thienodiazepines]
Last edited:
).
