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OD Moderators: Keif’ Richards | negrogesic
Misc etifoxine in combination with benzos
- Thread starter murder
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adder
Bluelighter
- Joined
- Mar 28, 2006
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- 2,851
Both etifoxine and alprazolam (Xanax) bind to GABA(A) receptors, however distinctly. GABA(A) receptors are formed of 5 subunits combined in various ways. Most GABA(A) receptors have 2 alpha subunits, 2 beta subunits, and one gamma subunit, e.g. you can have a GABA(A) receptor built from two alpha-1's, two beta-2's, and one gamma-2 (these are actually the most common subunits).
Benzodiazepines are positive allosteric modulators at GABA(A) receptors, which means they bind at a different site than GABA does and they change the conformation of the receptors, so GABA can bind stronger, hence the anxiolytic and muscle relaxing effects among other effects. Etifoxine seems to be doing the same thing but it does that binding to different subunits.
Now classic 1,4-benzodiazepines mostly bind to alpha-1, alpha-2, alpha-3, and alpha-5 subunits, and etifoxine binds to beta-2 and beta-3 subunits. So alprazolam will bind to GABA(A) receptors at alpha-1 subunits while etifoxine will bind at beta-2 subunits. The idea of taking both drugs together is that they bind at different sites, so they don't interfere with each other, but possibly complement each other creating a stronger effect. However, I don't really know why you would do that. Prolonged use of benzodiazepines changes conformation of GABA receptors for a very long time, that's simply damage. Etifoxine is said to have fewer side effects, but I've no idea whether it may cause a withdrawal similar to withdrawal from benzodiazepines. I suspect yes, but the question is how severe it is.
Benzodiazepines are positive allosteric modulators at GABA(A) receptors, which means they bind at a different site than GABA does and they change the conformation of the receptors, so GABA can bind stronger, hence the anxiolytic and muscle relaxing effects among other effects. Etifoxine seems to be doing the same thing but it does that binding to different subunits.
Now classic 1,4-benzodiazepines mostly bind to alpha-1, alpha-2, alpha-3, and alpha-5 subunits, and etifoxine binds to beta-2 and beta-3 subunits. So alprazolam will bind to GABA(A) receptors at alpha-1 subunits while etifoxine will bind at beta-2 subunits. The idea of taking both drugs together is that they bind at different sites, so they don't interfere with each other, but possibly complement each other creating a stronger effect. However, I don't really know why you would do that. Prolonged use of benzodiazepines changes conformation of GABA receptors for a very long time, that's simply damage. Etifoxine is said to have fewer side effects, but I've no idea whether it may cause a withdrawal similar to withdrawal from benzodiazepines. I suspect yes, but the question is how severe it is.
tricomb
Bluelight Crew
I bet that would be one of the worst withdrawals imaginable
phatass
Bluelighter
^^ No i don't think it's recreational on it's own, having got some otc here if i remember correctly, more of a "potentiator" of benzos i read on Wiki.
der-a-morphine
Greenlighter
- Joined
- Feb 20, 2014
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- 4
Ya ive tried etifoxine. I personally am not a huge fan. Nothing like benzos even though information says its actions are similar to benzos. I think they mean the therapeutic value is similar to benzos as an anticonvulsant and anxiolytic. They are mildly effective for anxiety therapeutically, but theres nothing recreational about it by itself. Though it is one powerful benzo potentiator. I took two 50mg caps with some alpraz one night and pretty quicky the night became a blur. It may have some potential I suppose. But I think there are better anxiolytics out there, specially ones that dont have such a high risk of possible liver damage.