Stimulants Ethylphenidate with dexedrine - safe?

[RobotRipping]

Just wondering if this is a safe combo...

EPH being a DNRI and dextroamphetamine being a releaser at a high enough dose, is this a safe mix if dexedrine was taken 4 hours ago? (30mg)

do they cancel each other out? i can't find any solid info on this combo in particular, so all i have to go on is adderall or dexedrine mixed with methylphenidate which some people say cancel each other out and others say there's no problem at all.

I won't be mixing EPH with d-amp at the same time, just taking EPH on the tail end of the d-amp, so in theory at least, bad idea? good idea? synergy? cancel each other out?

Thanks for any help and sorry i know drug combos go in basic discussion but i find OD gets more intelligent responses in regards to pharmacology and drug combos.

 

[sekio]

Depends on the order you take them in, and the dose.

Taking a high enough dose of high-affinity NDRI before amphetamine will stop some of the the amphetamine from binding, reducing the effects.

Otherwise it would work pretty much like you expect. There's a pretty significant risk of getting uncomfortably tweaked out and having a hypertensive crisis/panic attack if you overdo it.

ethylphenidate is pretty close to methylphenidate in terms of effects.

 

[RobotRipping]

^i don't personally find so, MPH is much more tweaky as it is more of an NRI than a DRI like EPH. Then again some people prefer straight up stimulants that work on NE (ethcathinone is fucking great) so perhaps it's just a matter of preferences.

My only concern is that my d-amp dose over the last 26 hours in total is 120mg (been up for 26 hours as well) and i was reading at high doses d-amp starts to just straight up release DA and NE, and then adding a DNRI in there, would somehow lead to too much dopamine/NE in the brain but i'm not very well read on the pharmacology of EPH or amphetamines in general.

Thanks for the prompt answer, snorted a small line before reading it though lol

so EPH after d-amp and not the other way around; works for me, so long as my heart doesn't give out i'm cool.

 

[sekio]

snorted a small line before reading it though lol

Why do you even bother asking these questions then? I don't understand, why do people take drugs first and then figure out if it's safe?

would somehow lead to too much dopamine/NE in the brain

That is exactly what the risk is. Hypertension (high blood pressure), palpitations, panic attacks, paranoia, akathisia, repetitive behavior, and so on.

Not sleeping, relatively high doses of amphetamine (>10mg a day), and compulsive redosing will all make it more likely you'll experience these bad effects.

Not to mention doing NDRIs will only worsen the eventual crash.

 

[RobotRipping]

well after doing enough looking around and seeing others mixing amps with MPH, and seeing that Drs sometimes prescribe an amp with MPH, i figured a small line wouldn't hurt and if it did, i could just etizolam it out.

I just wanted to know if there were serious risks involved with moderate use, like something like serotonin syndrome but for dopamine or perhaps something like a seizure/cardiac arrest but couldn't find anything for EPH in particular, so went off on info based on MPH reports; yeah not a great idea in terms of harm reduction I agree.

what's a relatively high dose of amps anyway? i get scripted 100mg/day just for add lol

 

[mrflowers00]

i'm not sure about and NDRI with a drug that releases dopamine and N cause i can't spell it but SSRIs taken before MDMA make it much less effective but haven't noticed anything different when taking the next dose of the SSRI after taking the MDMA

 

[RobotRipping]

^seems the same thing happens with DNRIs when taken before a releaser but i'm not exactly sure why (receptor affinities?), as i'd think more DA and NE would be in the brain making for a better high. A DNRI like EPH, MPH or the many others seem to diminish the effects of a DA/NE releaser if taken before the DA/NE releaser but user reports seem to vary on this as well. I also understand that at lower doses amphetamines also act as inhibitors for transporters of DA/NE but at higher doses, release them as well so i'm assuming it varies with dose.

I can't really tell if taking d-amp earlier made a difference, it's a much better stimulant than EPH but EPH also has a much different feel to it, less euphoria, more of a rush and tweak to it but i don't fiend for it nearly as bad as i used to, maybe being on d-amp daily helps with that, not sure, hopefully it helps with the hell of a crash i'll probably face tomorrow!

overall though, probably snorted 80mg of EPH tonight and no negative effects other than being scatter brained from being awake for 36 hours, probably going to feel like shit tomorrow but that's normal. At least the shadow people haven't made an appearance yet.

just in case anyone is wondering; it's just simply not the case that if you take EPH even at high doses before d-amp that it blunts the effects of the d-amp, it's additive if anything. Unless there is some evidence against that all anecdotal reports suggest that this is indeed the case, EPH, MPH, cocaine will not block amphetamines when taken before, and are relatively safe if taken afterwards so long as you don't over do it and go into cardiac arrest, definitely have benzos around if you do such things tho! EPH and d-amp is a shit combo tho, too much dopamine, not enough NE. d-amp would go amazing with ethcathinone i bet.