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  • N&PD Moderators: Skorpio | someguyontheinternet

Endorphins

No, endorphins don't cross the BBB.

There is no legitamite evidence that the post workout high is caused by endorphins (that's something the media ran with). Though if you injected into your brain, you'd probably like it.
 
What is it that allows a drug to cross the BBB? I've been looking around and it seems that the only guides as to what can cross come down to size of molecule and polarity. Furthermore, if the technology doesn't exist currently to figure out what allows a chemical to cross the BBB, what would it take?
 
Size and polarity... yup... that's it. Oh, and they can't be substrates for multidrug transporters.
 
Check out the distribution section in the new chapter on pharmacokinetics in the BlueLight/Erowid textbook here
 
We don't know. It could be other endogenous opioids, but it's probably a mix of a huge number of things (I suspect noradrenaline and adrenaline are big players)
 
Yeah, there was a paper that caused a bit of a stir in the popular media [1]. The anandamide was quantified with mass-spec, so I believe that the exercisers had higher blood anandamide levels, though I strongly doubt they came from the brain (though they may have). But under exercise, you get all kindsa changes, because it's a physiologically stressful event that requires large changes in bodily functions so you're gonna get heaps of changes. Serotonin in the -brain- goes up during exercise[2]. So does Glutamate, dopamine and noradrenaline[3].
 
I'm not sure... I can't find any evidence of anyone giving it IV.
 
^ Yeah, um, No. I'm so fucking sick of that.

No one knows what beta-endorphin feels like because no one has been sitting there, and then been informed, "in 3 seconds beta-endorphin is exclusively being released in your brain".

As I have said about a billion freaking times, the evidence that exercise releases beta-endorphin was completely methodolically flawed. Furthermore, even if it wasn't, it still wouldn't mean anything, because it was looking at beta-endorphin levels in the blood, not in the brain. Finally, there is good evidence that excersie DOES NOT increase plasma beta-endorphin levels.

Likewise, the evidence on sex was blured by the same methodological flaw.

Finally, there is no evidence one way or another, that I can find, that actually shows endorphin release before, during or after feeding.
 
Thats what I've heard my whole life at least, I believed it.

So if thats not the answer Bilzor, I'd expect you to be able to give it to us.

Its not the food/sex/exercise thing, its going to be more complicated than that.
Any ideas?
 
Sphinx (Afterlife) said:
Would injecting exogenous human recombinant endorphin peptides be able to cross the BBB?

What endorphin(s) control mood? In otherwords, when I workout and I get 'happy', what endorphin is causing this, and could I inject it and get 'high' ?
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I printed off a whole section on peptides a few weeks back and have still been preoccupied to read it yet. It might seem a bit sad to you something as snazzy as peptide synthesis to do make an opioid. However on the otherhand it seems like a neat idea!

The ability to program peptide synthesis has a host of other medical uses as well. I also read that if you use D-a.a's instead of the naturally occuring L-a.a residues then enzymes find the drug more resistant to metabolism. The draw back of this is that the a.a's are then more expensive since they have to be made artificially in a laboratory.

http://rapidshare.de/files/3899022/centan.zip.html

The 2nd section in the above e-book deals with this topic extensively although I have not personally read it yet.
 
Thats what I've heard my whole life at least, I believed it.
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Yeah well they say lots of shit on TV, and then people repeat in on here, and then lies get repeated over and over again.

So if thats not the answer Bilzor, I'd expect you to be able to give it to us.

Its not the food/sex/exercise thing, its going to be more complicated than that.
Any ideas?
Click to expand...
Well there is evidence that some endogenous opioids are released by stress, but so are serotonin, dopamine and noradrenaline, as well as the endocannabinoid evidence: all kinds of physiological changes go on, so it's pretty hard to narrow it down. The evidence isn't there to make a solid conclusion.
 
51144endorphins_and_excerise.gif
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A) is blood endorphin as measured by the methodologically flaw method (you can see the peak after the exersise, which lead to the false reports). B) is real Beta-endorphin, and you can see there is no real correlation between exercise and endorphin levels
 
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