el saint -- There is some Effexor info in Health Q & A if you do a search, but as I've been on it myself, I'll give you my personal input.
Before taking Effexor, I had taken Prozac for a couple months and another time, Remeron (a newer, non SSRI antidepressant) for a couple months as well. My doctor prescribed the Effexor because Remeron didn't work, and although Prozac DID work very well, I also suffered many side effects (no libido, couldn't orgasm, felt dazed all the time, emotional numbness, slept too much/tired all the time, weight gain). Effexor supposedly had a lower incidence of these side effects -- largely due to the fact that Effexor is an SNRI (serotonin norepinephrine reuptake inhibitor). This means that in addition to affecting the serotonin system much the way an SSRI does, Effexor also has a significant effect on norepinephrine (which is one of the chemicals released when you roll, and is a stimulating neurotransmitter), and minor effect on the dopamine system. The NE and dopamine effects of Effexor mean less (usually no)fatigue, less sexual dysfunction, and less weight gain -- all of which I was looking for.
At first I tried Effexor IR (instant release in tablet form -- you can take it all at once or spread out a couple of times a day) -- and it gets into your brain pretty much all at once. I also tried Effexor ER (extended release) in capsule form -- this type is MUCH more commonly prescribed and my doctor even had free samples -- the Effexor is slowly released in your brain. Effexor ER made me tired and gave me headaches -- and Effexor IR woke me up, and when I first was taking it (on days that I would go up in dosage) it even made me slightly high (though it doesn't have real recreational value).
Your doctor should prescribe the Effexor on a very gradual taper...mine was 12 1/2 mg for 4 days, then 25 mg for 4 days, then 50/4 days, then 75/4 days, then 100/4 days, then 150/4 days, then 200/4days...and so on by 50 mg increments till I got to 400 mg (maximum dosage is 450 mg). This taper is REALLY necessary because it takes your body a while to adapt to the Effexor, and you can get nausea and dizziness if you go up too quickly. Because my doctor knew what he was doing, I didn't suffer the side effects when starting Effexor that most people do.
It took about 6 weeks for it to start working.
While on the Effexor, I experienced decreased appetite (and as a result, lost abot 10 lbs then stabilized at that weight for as long as I was medicated), and a fair deal of alertness (esp right after I would take my medicine...it was like an afternoon pick me up!). I experimented with various times to take it...and found out that the best time to take it was around lunch time. Any earlier, and it made me tired and would sometimes upset my stomach. Any later, and I woudldn't be able to sleep at night. My libido was fine (if anything, I was hornier) but I was not able to come...which was rather frustrating.
AS far as it helping my depression -- well, I was taking it mostly for obsessive compulsive disorder and only had mild depression -- but it definitely did help. It was not as effective as Prozac, like I said, but it definitely still helped alot. I also liked the way it made me feel -- I still felt like myself, could still feel a full range of emtotions (yet didn't get stressed out by every little thing like I do unmedicated), and I felt alert all day long. I definitely enjoyed being on and found it very helpful -- and MANY times better than the other meds I had been on before.
I couldn't roll at all on Effexor, I could do meth (though it fucked me up less than it normally would), and coke was stronger and last longer ( a nice little bonus).
After 3 months, I decided to go off Effexor because -- 1) I wanted to be able to orgasm, 2)I wanted to be able to roll, 3) I didn't want to be taking meds for any longer than I needed to. I went of Effexor on a VERY very gradual taper (down by 50 mg every week...then by 25 mg/week after I got down to 100 mg)...and still, despite this, I suffered some withdrawal (esp when I got down to lower dosages). The withdrawal consisted of occasional mild nausea, dizziness, some fatigue (as well as some restlessness at night), and electric shocks.
The dizziness and especially electric shocks got really bad for the last 2 weeks - and even last for a week after I had completely stopped taking the Effexor(and then, rarely, I would get electric shocks for up to a month afterwards). The electric shocks/withdrawal weren't entirely unpleasant, except for a day or two (after which I quickly realized I needed to taper more slowly/take more Effexor). I kind of felt fucked up for a lot of withdrawal, in a weird sense. But it certainly wasn't that great of a feeling either...definitely don't miss or skip doses while on Effexor.
Supposedly going on a low dose of an SSRI while tapering off Effexor can help withdrawal...and this is what I suggest ( I did things the hard way, though I still tapered very gradually).
Anyways, I hope my story is helpful...I dont' know your psychological history or what antidepressants you have taken in the past. I'm sure that you'll hear that Effexor is both terrible and wonderful from a wide range of people -- all I can tell you is that I personally liked it and found it helpful, and that it can never hurt to give it a try.
If you have any other questions, I'd be happy to answer them, or you could email me if you need more advice...good luck!
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You can be rich and still be a fucking moron loser who smokes crack all the time. -- Kyk