Easest way of modifying Methamphetamine, to something else and keep most of effects?

[Reminisant B]

Wont work as it'll rearrange into the N-methyl imine (which will hydrolyse to benzyl methyl ketone/phenylacetone and methylamine) a la keto-enol tautomerism

thankyou, had been pondering why such a simple molecule hand't been looked at but that would make a lot of sense. Put my mind at rest.

 

[snowblowjoe]

what is 4-f-ma? and what does it suppose to feel like?

 

[/navarone/]

I've always been curious about the effects of 3,4-dihydroxyamphetamine which is practically identical to dopamine but with a CH3 on the alpha carbon, it should have a higher affinity for the receptor i guess. also 3,4-dihydroxymethamphetamine sounds good huh?.

anyone got info on these substances?

btw phenylephrine (a common decongestant) which is 3,beta-dihydroxy-methyl-PEA might become a cousin of ephedrine since those 2 hydroxyl groups can be easely converted to form plurious kinds of new phenylethylamines.
hehe, what do you thing bout that?

 

[vecktor]

I've always been curious about the effects of 3,4-dihydroxyamphetamine which is practically identical to dopamine but with a CH3 on the alpha carbon, it should have a higher affinity for the receptor i guess. also 3,4-dihydroxymethamphetamine sounds good huh?.

anyone got info on these substances?

btw phenylephrine (a common decongestant) which is 3,beta-dihydroxy-methyl-PEA might become a cousin of ephedrine since those 2 hydroxyl groups can be easely converted to form plurious kinds of new phenylethylamines.
hehe, what do you thing bout that?

known metabolite of alphamethyl DOPA, not centrally active but has interesting effects on the kidneys also the heart causes drop in BP if I remember right. ring hydroxy amps are not centrally active as a rule. 4 hydroxy amp is a known metabolite of amp and has been investigated, inactive as CNS stimulant though has cardiovascular activity.