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Easest way of modifying Methamphetamine, to something else and keep most of effects?

I

InsaneSpeedball

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Joined
Feb 7, 2007
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8
This has proble been discussed, or been done to death already. Cased close of something. Anyway, I take my chances for humilation. =D

The object: Alter the methamphetamine, add/sub an atom or more somewere, making it a slight different substance, that would make a legal with some luck. And still have most of the potential, proporties of meth.

Does adding things to the molecule, wherever you put it, change, remove, charataristic of Meth very dramatic? Or worst case scenario, making it complety unactive.

The OH group in the top, which make it efedrine, makes it very different, probably the same with 0, methcat.

But on the benzen ring...? And trying to beware creating some extreme 60hours amphetamine based psychedelic as a result.

Anyone cares to lecture me. ;)
 
giantsquid said:
it would fall under the analog laws of some countries
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Ok, that means that every substance that is very simular to an illegal one, will be by auto, illegal to? How long does is stretch? And what is the exakt defination, rules for calling something an analog, how simular must it be?

Ok, were I live, I don't think we have that law...yet. Some new substances that comes up, either get schedule narcotic, or some is just put under a section called, something like "Unhealthy Goods", which means they are not allowed to be selled. But not illegal to possess. And things takes time here.
DOI for example is still legal so far. Which is a pretty heavy drug.
 
You can oxidize it to N-hydroxymethamphetamine with hydrogen peroxide, which should have exactly the same effects.

But it is no use probably as it would be hard to get out all traces of the starting methamphetamine.
 
ralf2 said:
You can oxidize it to N-hydroxymethamphetamine with hydrogen peroxide, which should have exactly the same effects.

But it is no use probably as it would be hard to get out all traces of the starting methamphetamine.
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Doing some finetuned destillation? But I guess the boiling point difference would be to small, to make it work. But who knows, I wonder what the boiling point for N-hydroxymethamphetamine is.
 
To my knowledge, it is VERY easy to stick a halogen (except Fluorine) on the 4-position. The problem? They are all very, very, verty toxic (again, except for fluorine, funny eh?). :\ (I mean plain 4-halo-meth, without the 2,5-dimethoxy)
 
Jamshyd said:
To my knowledge, it is VERY easy to stick a halogen (except Fluorine) on the 4-position. The problem? They are all very, very, verty toxic (again, except for fluorine, funny eh?). :\ (I mean plain 4-halo-meth, without the 2,5-dimethoxy)
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I guess iodine is quite stable. Not climbing visciously out of the bottle when you open it. But I would pefer bromine. (Silly, just because I like 2-CB very much, and DOB was nice to. Not same feel with 2C-I and DOI.

But 4-Br-Meth. Wonder what ta would be, when the 2,5 dimethoxy is cut off.

A monster speed DOB like drug with minamal, none or different psydelic properties.

TI will take a look in PIKHAl.

/off topic
Haven´t scene a meth version of DOB, wonder what kind of monster that would be. But scins I havnt read any info about it, I guess it wasn´t anything useful.
 
the 4 bromo and 4 chloro and 4-iodo methamphetamines have the potential to permanently alter your state of mind, but not in a good way.
 
I can't think of anything more interesting than meth than can be synthesized from it off the top of my head.
 
InsaneSpeedball said:
I guess iodine is quite stable. Not climbing visciously out of the bottle when you open it. But I would pefer bromine. (Silly, just because I like 2-CB very much, and DOB was nice to. Not same feel with 2C-I and DOI.

But 4-Br-Meth. Wonder what ta would be, when the 2,5 dimethoxy is cut off.
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I'm telling you, its a known fact that these things are VERY TOXIC.

In fact, they are usually blamed for much of Meth's toxicity because 4-Iodo-meth is found as an impurity in street meth.

PLEASE don't do this!

EDIT: I WANT TO STRESS THE TOXICITY. These compounds are KNOWN to cause long-term serotonin depletion.
 
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Well, so is MA itself... using MA on a frequent basis is terribly bad for your head, it's a standard as a neurotoxin without any substitution.
 
N-propylamphetamine would be somewhere inbetween regular amph and meth in effects but be "legal" (but an analog..)

N-ethyl-amphetamine is banned but even better than propyl (from what i've heard)
 
InsaneSpeedball said:
Doing some finetuned destillation? But I guess the boiling point difference would be to small, to make it work. But who knows, I wonder what the boiling point for N-hydroxymethamphetamine is.
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hint n-hydroxy methamphetamine is convertable to base (freebased) at a lower pH than methamphetamine.
 
^ Isn't it a tad unstable though? There#s a case on the UK legal reports of soimeone trying to circumvent the MoDA by manufacturing N-hydroxy DOB. Unfortunately it wasn't the most stable of compounds so when he was caught with some, a percentage of it had decomposed back to DOB. Result being,'do not pass go. do not collect £200...'

4 halo amphetamines & N-alkyl analogues are incredibly neurotixic to serotonogic neurones and are used to destoy said neurones in experimantal animals. A one off dose of one of the 4-Cl/Br/I meth would cause more damage than a lifetime of hammering MDMA. It is to be avoided like the plague.

In fact, they are usually blamed for much of Meth's toxicity because 4-Iodo-meth is found as an impurity in street meth.
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That;s what you get for using the RP/I method for synthing meth (as well as plain toxic to every organ compounds like 2-phenyl-1,3-dimethylaziridine whic is esp nephrotoxic - fucks your kidneys)


The only options are to replace the N-methyl with groups of 4 carbon or less (& even the M-butyl compound is 1/10th the potency of amphetamine; N-propyl is about 3/5th the potency of amphet and N-ethyl is comparable to amphet potency wise but is in subjective experience the niddle child between amphet & meth. Smoother & more euphoric than amphetamine, but less neurotoxic than meth. Once you start sticking groups on the ring you radically alter the subjective nature of the drug (4-F meth is entactogenic; 3-F is more of a CNs stimulant, but supposedly nowhere near as euphoric, 4-methyl meth has a huge drop in potency)
 
To my knowledge the broadest analogue laws in the world is this one from New South Wales in Australia;

Any substance that is an analogue of a drug prescribed in this Schedule, being a substance that has psychotropic properties, is not separately specified in this Schedule and is, in relation to the drug, any of the following:(a) a structural isomer having the same constituent groups as the drug,(b) a structural modification obtained in one or more of the following ways:(i) the replacement of up to 2 carbocyclic or heterocyclic ring structures with different carbocyclic or heterocyclic ring structures,(ii) the addition of hydrogen atoms to 1 or more unsaturated bonds,(iii) the addition of 1 or more of the following groups having up to 6 carbon atoms in any alkyl residue, namely, alkoxy, cyclic diether, acyl, acyloxy, monoalkylamino and dialkylamino groups,(iv) the addition of 1 or more of the following groups having up to 6 carbon atoms in the group and being attached to oxygen, namely, alkyl, alkenyl and alkynyl groups (for example, ester groups and ether groups),(v) the addition of 1 or more of the following groups having up to 6 carbon atoms in the group and being attached to nitrogen, sulphur or carbon, namely, alkyl, alkenyl and alkynyl groups,(vi) the addition of 1 or more of the following groups, namely, halogen, hydroxy, nitro and amino groups,(vii) the replacement of 1 or more of the groups specified in subparagraphs (iii)–(vi) with 1 or more other groups so specified,(viii) the conversion of a carboxyl or an ester group into an amide group.
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A compund that falls outside those restrictions can be expected to be legal everywhere. On the other hand though in NZ and the USA their analogue provisions don't specify anything, new compounds are illegal just for being "substantially similar" to scheduled drugs, and there being no definition given in the law for what substantially similar actually means, its impossible to say for certain whether any novel compound is illegal or not...strictly speaking they could say that a compound is substantially similar because it has an aromatic ring seperated from an amine group by an alkyl chain, which would cover pretty much all psychoactive drug analogues known...
 
^ I know, it's criminal that they're allowed to be so vague. In a way that could be used to arrest and detain anyone on the basis of an analogue chemical. It's basically arrest & seizure without due cause made legal (which is worrying in these times)
 
Make something new. It would appear that people here have already got hold of novel, legal & very impressive compounds. It's just fine tuning.
 
I really hope my country does not get analog laws, but it's pointing in that direction. I really hope the guys who have to review new laws for legal security can stop it. They have stated analog laws are bothersome because you don't know exactly what is illegal, which is a big problem. Hopefully they will stand up to this and prevent one more step to big brotherism.
 
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