Misc Earl Grey Tea (Oil of Bergamot) and Enzymatic Inhibition? (CYP450)

[splenda]

Apparently Earl Grey tea has oil of bergamot in it. As we all know, this is the source of bergamottin, the apparent chemical that is involved with inhibiting cytochrome p450 enzymes and is the main constituent in grapefruit juice that gives GFJ its CYP450 inhibiting effects. Knowing this, will drinking earl grey tea inhibit the metabolism of drugs because of the oil of bergamot (just like GFJ)?

It would be interesting to get more of an effect out of my daily morning methadone dose (160mg) by drinking a cup of earl grey tea the night before/1-2 hours after dosing. Does anyone know about earl grey tea/oil of bergamot and their interactions with the CYP450 enzymatic family and how it interacts with drug metabolism?

Thanks! If mods find this more suitable for Advanced Drug Discussion, please move.

Oh, and on side note, since I was researching and purchased a bunch of teas/tisanes today... rooibos unfortunately induces CYP3A4 as seen in the following Japanese study... and I spent $7 on rooibos today and I can't return it because I already drank about half a cup of it (and threw the rest out as soon as I found this study; as I don't want it to induce the metabolism of my methadone since methadone is a substrate of CYP3A4.)

http://sciencelinks.jp/j-east/article/200707/000020070707A0177014.php

 

[splenda]

So I picked up a tin of loose leaf Twinings Earl Grey Tea and am using a tea ball to brew it.. I plan to brew and drink a cup tonight and tomorrow 1-2 hours after my methadone dose. I'll mark down if I notice any increase in methadone effects.

Also, I bought lady grey tea too. I plan to drink that before I have the plain earl grey tea. Apparently Lady grey tea contains synephrine/bitter orange peel but I'm not 100% sure on that... I'm not too sure if it has oil of bergamott either though, but I'll check it out either way.

So, does anyone have any information on lady grey tea also? Thanks!

 

[llamer]

well i betcha that grapefruit juice is a better source of this rather than earl grey, but that's just an opionion. good luck

 

[dokomo]

Has anyone been able to find a quantification of bergamotten in grapefruit juice or Earl grey tea?

 

[splenda]

Has anyone been able to find a quantification of bergamotten in grapefruit juice or Earl grey tea?

On my tin of Twinings Earl Grey Loose Leaf Tea, it says "Bergamottin Flavoring (4.3% )"

 

[Jabberwocky]

I'm glad someone posted this. I've been noticing that after drinking a cup of Earl Grey tea (expensive brand, loose tea leaves that I strain) my dihydrocodeine is potentiated enormously. At first I thought I was just getting more relaxed for some reason due to drinking tea, but now I know it's not just a mental thing. The nights I'd been drinking tea my mother noticed that I had been snoring loudly in the night, but the dangerous kind of snoring, despite taking the dose I've been regularly taking for a long time now.

People should be careful when drinking Earl Grey in particular with some substances. I believe it's an inducer of some sort. And it's quite potent to boot. I've always been a fan of Earl Grey tea, and I only picked up a pot recently once again as I'm a big fan of this particular brand.