e and schitzophrenia(sp)

[emagdnim]

Schizophrenia is believed to be cause by elevated levels of serotonin in the brain, as the opposite is believed to cause depression.
[ 24 January 2003: Message edited by: emagdnim ]

 

[nowonmai]

^^
it's actually elevated dopamine levels, mate

 

[5-HT2]

^^^actually, its more likely to be overexpression of the D2 or D4 receptors rather than dopaminergic hypertransmission.

 

[5-HT2]

Originally posted by synchrojet:
In any event, I think schizophrenia is still so misunderstood that there can be no reliable conclusions drawn about the impact of these drugs on the schizophrenic mind.
You are wrong. These drugs have been shown to exacerbate psychotic symptoms or trigger acute psychotic episodes in schizophrenics. In addition, the metabolic activity produced in the brain by psychedelics is strikingly similar to that observed in acutely psychotic schizophrenic patients. The "atypical" antipsychotics are highly efficacious at both treating neuroleptic-resistant schizophrenics and antagonizing the effects of psychedelics, indicating that the two share common mechanisms of action. Based on this evidence, it is very reasonable to conclude that these drugs may exacerbate or trigger psychosis in schizophrenics.

 

[Vamp*]

My ex boyfriend used ALOT of e and speed etc.... and while i was with him he lost his mind. He thought people were after him with guns... he was skizo....and the 'e' brought it on i can tell u that. He was fine... but everytime he start doing drugs again he'd lose it.

 

[MerryGlowstick]

E brings out the schitzo in people, medically, being on e is the same as having schitzo, schitzo have stiff jaws and everything!

 

[5-HT2]

Originally posted by MerryGlowstick:
E brings out the schitzo in people, medically, being on e is the same as having schitzo, schitzo have stiff jaws and everything!
This is wrong. Being on E is nowhere near the same as having schizophrenia. Being on a 5-HT2A agonist hallucinogen such as LSD, psilocybin, or DOI does produce neurological and behavioral symptoms that are similar, but not identical, to the acute, positive psychoses that often typify the initial stages of schizophrenia. Now, MDMA is a weak 5-HT2A agonist, but its activity at other receptors does not make it as accurate of a model for acute schizophreniform psychosis.

 

[5-HT2]

Intriguing. So basically, what you are saying in this case is that an acute psychosis (of the positive form) is what follows the negative type forms of schizophrenia manifested by depleted serotonin levels cuased by mdma or stress or something else of a negative nature?[/QB]

Actually, it's usually the other way around, with negative symptoms, a sign of chronic psychosis, following the positive symptoms of acute psychosis.

(such as speed psychosis where positive form schizophrenia is iniated by an overwhelming increase in adrenaline coupled with a decline in dopamine levels)

Correction: Speed psychosis is caused by elevated levels of BOTH dopamine and adrenaline, a well as noradrenaline.

If so, would it be fare to say, when compared to other types of drug induced psychosis, that positive symptom psychosis as a result of mdma usage is the most unlikely form in which drug induced psychosis is likely to occur?

No, you could not say that at all. The high from arguably any type of stimulant, entactogen, or psychedelic can mimic positive psychotic symptoms, while it is the COMEDOWN that can mimic the negative symptoms of blunted emotions and social withdrawal. Positive psychotic symptoms are just as likely of a result from MDMA usage as negative symptoms.