DXM - New experience

[Twisted_Shroom]

I had about 1/6 a bottle left of my Purple drank and decided to make the special drink. My friends and myself were at a keg at some field outside and it was a pretty chilly night. I started chugging the purple drank so I could feel the so-called buzz from the codeine opiate but it never came, although the syrup was Prometh/codeine.

Not being satisfied with the environment or result, me and a friend left the outside party to go to a house party. Before the house party, we grabbed some grub at Taco Bell which turned out to be a huge mistake. Later on that night, before we entered the party, I bought DXM cough pills and took all 20 for a 300mg of DXM intake. Worst idea of my life.

That night I was waiting for the DXM to kick in as I knew it would because it always delivered for me, and, I love DXM trips. Well eventually, I ended up in the yard of the house party where the DXM kicked in.

First of all, I threw up everything I ate at Taco Bell. My stomach was turning and my body was shifting. I started to feel hot flashes and my started to sweat from homeostatic imbalance. That night I felt like I was dead, literally. I didn't know if I was alive or if I was going to actually die, but I felt out of my body and didn't feel alive. Once I went in the house, my body turned rather cold and remained that way, except for this recurring hot flash that ran through my body and ravaged my mentality.

At the same time, I locked my keys in my car. I thought someone was going to steal my car that night and couldn't relax which might have led to a bad trip (I didn't really mind the vomit, just the heat flashes). Anyways, I tripped off the DXM and felt alright besides the heat flashes, later thinking that it was stupid to do DXM, Prometh/codeine all in one night.

Me and a friend of mine stayed up all night and went to breakfast in the morning, and damn, nothing leaves a better morning feeling/high than DXM.
My friends grandfather hangered my lock so we got into my car and everything from than was turning out good. I love DXM, but never again will I mix it with Sizzurp in the same night.

 

[o24742o]

honestly, you are lucky to be alive, i dont remember how much of the opiates you took, but mixing ANYTHING with dex never turns out well. also mixing drugs with ketamine or PCP always end with bad news. i've had a bad trip on dex years back, when i took about 300 mg worth. i mixed it with alcohol xanax and marijuana and i got my ass kicked lol. dex is and K are nothing to fuck around with. mixing them with other drugs has always failed for me.

 

[Tirux]

I've mixed DxM with weed a time or two, and it doesn't seem to go sour, actually, it can help sober you up, in my opinion. If you smoke weed with it, I believe it takes a bit off of your DxM experience and puts more of weed in it.

A different way of explaining it:

Say you take 300mg of DxM and then you do however much of weed, well lets say you "took" 50mg of THC, that would then take 50mg of DxM and replace it with the THC. It doesn't go into the mix as something extra, it replaces.

I wouldn't trust anything being mixed with DxM, and what I do trust isn't worth mixing into it. DxM is a solo drug all the way, and is absolutely wonderful for just what it is by itself ^-^

~Stay safe and happy tripping everyone ^-^~

 

[fatstep]

I've mixed DxM with weed a time or two, and it doesn't seem to go sour, actually, it can help sober you up, in my opinion. If you smoke weed with it, I believe it takes a bit off of your DxM experience and puts more of weed in it.

A different way of explaining it:

Say you take 300mg of DxM and then you do however much of weed, well lets say you "took" 50mg of THC, that would then take 50mg of DxM and replace it with the THC. It doesn't go into the mix as something extra, it replaces.

I wouldn't trust anything being mixed with DxM, and what I do trust isn't worth mixing into it. DxM is a solo drug all the way, and is absolutely wonderful for just what it is by itself ^-^

~Stay safe and happy tripping everyone ^-^~

Dont take this as being a dick, but this is completely wrong. Bud is a CB- Agonist while DXM is an NMDA receptor antagonist, basically meaning they affect completely different systems in the body. It's understandable how you feel as if it brings you back to reality, it does the same for me, but that's only because DXM is a dissociative anesthetic and bud just brings your mind back to your body, so to speak.

 

[Tex@s]

Ok imma try and make this not too long fellas.

Dextrorphan is a metabolite of DXM (i.e., the body converts DXM to dextrorphan). The conversion from DXM to DXO occurs via removal of the methyl group at position 6, a process called "O-demethylation". DXO is very similar chemically to DXM, and reacts with the same receptors in the body, but with a very different spectrum. Whereas DXM is strongest at the PCP2 and sigma receptors, DXO primarily targets the NMDA receptor (see Section 10).

The practical upshot is that the dissociative and intoxicating or "stoning" effects are stronger with DXO, whereas the stimulation, cognitive alterations, delusions, and psychotomimetic (literally, "psychosis-like") effects are stronger with DXM. Most DXM users find some balance between the two to be the most pleasurable. Too much sigma activity is usually regarded as dysphoric (strongly unpleasant) and disturbing, and if prolonged, may be dangerous (101,135).

Fortunately, you don't have to worry about converting DXM to DXO; the body does it for you via an enzyme called P450-2D6 or CYP2D6 (also called debrisoquine 4-hydroxylase). However, between 5 to 10% of the Caucasian population lacks this enzyme (12-15), and in the rest of us it can vary. Many drugs can temporarily block P450-2D6 from working (10-11) and thus alter the balance between DXM and DXO. For a list of these drugs, see Section 15.1.

One of DXM's metabolites, 3-methoxymorphinan, can itself block P450-2D6. As a consequence, taking a second dose some time after the first dose of DXM will probably increase the ratio of DXM to DXO in the bloodstream. Taking the dose all at once, on the other hand, will probably increase the relative amount of DXO. Generally, then, the quicker the dosing, the more DXO and less DXM, and the more NMDA blockade (like ketamine) and the less sigma and PCP2 activity. Subcutaneous injection leads to very little conversion from DXM to DXO.

When discussing effects, this text usually uses "DXM" to refer to both dextromethorphan and its metabolite, DXO. A few people have used DXO specifically; one indicated that it did in fact have fewer cognitive effects than DXM.

This is a partial list of recreational and medical drugs which inhibit the P450 enzymes 2D6, 3A4, and 3A5. Not all of them will inhibit all of the P450 enzymes, but it's safe to say that a substantial number of these will interact with DXM.

Generally speaking, inhibitors of P450-2D6 include antidepressants (both SSRIs and tricyclics, and possibly MAO inhibitors), antiparasitics (especially antimalarials), antihistamines (both prescription and over-the-counter), neuroleptics, beta blockers (drugs for high blood pressure), and antineoplastics (anti-cancer drugs). Methadone is a P450-2D6 inhibitor, and it is likely that many alkaloids, especially of plant origin, may be mild to moderate P450-2D6 inhibitors. P450 Inhibitors Drug Uses P450-2D Enzymes Potency Ref
ajmalicine 2D6 strongest (164)
carbon monoxide poison 2D6 (160)
chloroquine antiparasitic 2D6 med-low (172)
chlorpheniramine antihistamine 2D med-high (151)
citalopram antidepressant 2D6 med-low (166)
clozapine antipsychotic 2D6 low (171)
desipramine antidepressant 2D6 low (152)
diphenhydramine antihistamine 2D med-high (151)
doxorubicin anticancer 2D6 med-low (165)
fluoxetine antidepressant 2D6 med-high (152)
fluvoxamine antidepressant 2D6 med-high (152)
imipramine antidepressant 2D6 med (152)
lomustine anticancer 2D6 med (165)
mepyramine antihistamine 2D6 high (151)
methadone addiction treatment 2D6 med (162)
moclobemide MAO-A Inh. (reversible) 2D6, also 2C19, 1A2 (147)
nortryptiline antidepressant 2D6 med-low (155)
oxamniquine antiparasitic 2D6 med-low (172)
paroxetine antidepressant 2D6 high (152)
PCP recreational 2D (150)
primaquine antiparasitic 2D6 med-low (172)
propranolol beta-blocker 2D6 low (156)
quinidine 2D6 (148)
quinine antiparasitic 2D (151)
sertraline antidepressant 2D6 med-high (167)
triprolidine antihistamine 2D med-high (151)
vinblastine anticancer 2D6 med-low (165)
vinorelbine anticancer 2D6 med-low (165)

Drug Uses P450-3A Enzymes Potency Ref
7,8-benzoflavone 3A4 (activator) (153)
cannabidiol component of marijuana 3A med (161)
cocaine recreational 3A low (157)
clotrimazole agricultural fungicide 3A (activator) very high (154)
cyclophosphamide 3A low? (158)
ifosfamide 3A low? (158)
ketoconazole 3A (145)
pilocarpine cholinomimetic 3A low (149)

Drug Uses P450-3A Enzymes Potency Ref
1-aminobenzotriazole Nonspecific med-high (159)
chlorophyllin geriatric Nonspecific (146)
general anaesthetics Nonspecific (163)


One reference ((164)) gives the general characteristics of P450-2D6 inhibitors as
a positive charge on a nitrogen atom, and a flat hydrophobic region, the plane of which is almost perpendicular to the N-H axis and maximally extends up to a distance of 7.5 A from the nitrogen atom. Compounds with high inhibitory potency had additional functional groups with negative molecular electrostatic potential and hydrogen bond acceptor properties on the opposite side at respective distances of 4.8-5.5A and 6.6-7.5A from the nitrogen atom.
A computer model of the P450-2D6 cytochrome has been constructed ((170)).

So there you have it cannabis is effectively blocking the enzyme from converting DXM to DXO. And what did it say about that above?.....The practical upshot is that the dissociative and intoxicating or "stoning" effects are stronger with DXO, whereas the stimulation, cognitive alterations, delusions, and psychotomimetic (literally, "psychosis-like") effects are stronger with DXM. Most DXM users find some balance between the two to be the most pleasurable. Too much sigma activity is usually regarded as dysphoric (strongly unpleasant) and disturbing[/B]