Lightning-Nl
Bluelighter
- Joined
- Nov 11, 2012
- Messages
- 1,245
I happened to come across this study conducted in 2000 about the analgesic effects of Nitrous Oxide. The study measured the receptor affinity that N2O has for receptors in the body. They noted that N20 has mild opioid affinity. That alone I found interesting, however - to prove that this was the case, they pretreated the test animals with with a "Drugs which inhibit the breakdown of endogenous opioid peptides" and found that N20 had a much more powerful pain-killing effect when done so first.
Anyways, I started this thread because I wasn't aware of any drugs that could stop the reuptake of endogenous opioids. What's also interesting is the fact they hide the name of the first substances they used - only referring to them as "various inhibitors of peptidases." Doing a quick search on "inhibitor peptidases" gives for limited results for what the actual name of these chemicals are.
The other "reuptake inhibitor" is referred to as "Phosphoramidon." Again, after doing a quick search on this one, it turns back much more results - but the information about it is still limited. The only thing the Wikipedia article states is the fact that; such as grapefruit juice is an inhibitor of enzyme CYP3A4, phosphoramidon stops opioid peptides from being broken down by inhibiting the enzymes that are responsible for doing it.
From what I already know about endogenous opioids; they're secreted by the pituitary gland and therefore have an immediate and direct effect on the brain. I also know they're broken down almost immediately after they're released. So this leads me to assume that not only does phosphoramidon cross BBB (and therefore have a direct effect on the brain), but it must also inhibit all such enzymes around the body.
Anyways, this is entirely speculation and therefore isn't backed up by any medical proof, but rather my own prior knowledge. What is your guy's interpretation of this information?
I was unaware such chemicals existed until 10 minuets ago - did anyone else have any knowledge of these or their pharmacodynamics?
Anyways, I started this thread because I wasn't aware of any drugs that could stop the reuptake of endogenous opioids. What's also interesting is the fact they hide the name of the first substances they used - only referring to them as "various inhibitors of peptidases." Doing a quick search on "inhibitor peptidases" gives for limited results for what the actual name of these chemicals are.
The other "reuptake inhibitor" is referred to as "Phosphoramidon." Again, after doing a quick search on this one, it turns back much more results - but the information about it is still limited. The only thing the Wikipedia article states is the fact that; such as grapefruit juice is an inhibitor of enzyme CYP3A4, phosphoramidon stops opioid peptides from being broken down by inhibiting the enzymes that are responsible for doing it.
From what I already know about endogenous opioids; they're secreted by the pituitary gland and therefore have an immediate and direct effect on the brain. I also know they're broken down almost immediately after they're released. So this leads me to assume that not only does phosphoramidon cross BBB (and therefore have a direct effect on the brain), but it must also inhibit all such enzymes around the body.
Anyways, this is entirely speculation and therefore isn't backed up by any medical proof, but rather my own prior knowledge. What is your guy's interpretation of this information?
I was unaware such chemicals existed until 10 minuets ago - did anyone else have any knowledge of these or their pharmacodynamics?