Beenhead
Bluelight Crew
- Joined
- Nov 15, 2000
- Messages
- 3,675
This is why I asked for a citation and was ignored. Without seeing more info on this its sounds like someone just read elegant universe and tried to connect it to drugs with out understanding pharmacology.
The whole bit about Seratonin storing the brains information and hitting the active edge of the drug?!!
Seratonin does not interact in anyway with Psilocybin, LSD, or Mescaline. It simply binds to the same receptor that Seratonin does. They have a similar shape and therefore fit into the active site of the receptor. This changes the receptors shape and this shape change cintinues through the lipid layer to the intracellular space to perform an action, which is usually to release a G-Protein or similar.
The drugs Active edge? Please define? The drug has no active edge... unless I am misunderstanding. The drug is a cloud of electrons in orbit around nucleii, and the 2D representation of it is not what it actually looks like, one would have to run a Huckle or DFT calculation on LSD to make the electrostatic potential map to show show the true 3D shape and areas of high electron density and low electron density. Using this you can look at the active site of the protein inquestion and running similar, more complex models for the larger molecule, show areas of high/low ESP to figure out areas where the drug is likely to interact with the active site. This happens mostly with hydrogen bonding at what not with adjacent residues.
Seratonin does not spontaneously form dimers, trimers, oligomers, or any other ordered system inside the neuron, or in the synapse for that matter, so Im not sure about that either. all neurotransmitters are held in vesicles and released into the synapse. Within the vesicle and inside the synapse, they are in solution and moving about in a random fashion either in the cytosol or the intercellular space of the synapse. In order for small molecules to link up or form dimers or oligomers, you would need a very very high concentration and usually electrical charge, or during crystallization upon removal of solvent. You could take a very high concentration of a drug such as Psilocin and perform electrospray ionization to introduce it to a Mass Spectrometer and often times get dimers, trimers, and maybe higher, but this does not happen under physiological conditions.
The whole bit about Seratonin storing the brains information and hitting the active edge of the drug?!!
Seratonin does not interact in anyway with Psilocybin, LSD, or Mescaline. It simply binds to the same receptor that Seratonin does. They have a similar shape and therefore fit into the active site of the receptor. This changes the receptors shape and this shape change cintinues through the lipid layer to the intracellular space to perform an action, which is usually to release a G-Protein or similar.
The drugs Active edge? Please define? The drug has no active edge... unless I am misunderstanding. The drug is a cloud of electrons in orbit around nucleii, and the 2D representation of it is not what it actually looks like, one would have to run a Huckle or DFT calculation on LSD to make the electrostatic potential map to show show the true 3D shape and areas of high electron density and low electron density. Using this you can look at the active site of the protein inquestion and running similar, more complex models for the larger molecule, show areas of high/low ESP to figure out areas where the drug is likely to interact with the active site. This happens mostly with hydrogen bonding at what not with adjacent residues.
Seratonin does not spontaneously form dimers, trimers, oligomers, or any other ordered system inside the neuron, or in the synapse for that matter, so Im not sure about that either. all neurotransmitters are held in vesicles and released into the synapse. Within the vesicle and inside the synapse, they are in solution and moving about in a random fashion either in the cytosol or the intercellular space of the synapse. In order for small molecules to link up or form dimers or oligomers, you would need a very very high concentration and usually electrical charge, or during crystallization upon removal of solvent. You could take a very high concentration of a drug such as Psilocin and perform electrospray ionization to introduce it to a Mass Spectrometer and often times get dimers, trimers, and maybe higher, but this does not happen under physiological conditions.