Since the 1970s, the National Survey on Drug Use and Health (NSDUH) has queried a representative sample of U.S. households on their drinking, smoking, and illicit drug habits. This has revealed a decades-long picture of how many people abuse a variety of different substances. We’ve analyzed this data and separated them by age to show trends in use of 10 different classes of substances throughout four generations of Americans: the Depression-era Lucky Few (born 1923–1942), the Baby Boomers (1943–1962), Generation X (1963–1982), and Millennials (1983–2002). In examining the life course of each of these generations, we can see which proportion of, and at which ages, each reported using a given substance within the past year.