Drug Tolerance and Effects

[psychonautical420]

Okay, so I've been talking with my boyfriend about drugs and their effects while a tolerance is in place. He thinks that even if there is a tolerance, drugs will still have the same effect on things like heart rate. I disagree with this. It makes sense to me that if you have a tolerance to a drug, it will no longer have any effects as intense as without a tolerance. I think that if you have a tolerance to amphetamine, for example, the mental AND physical effects will decrease, unless a higher dosage is ingested. He seems to think that if you have a tolerance and need, say 80mg instead of 20mg to get "high", that your heart rate will be higher than before when using 20mg to achieve the same mental effects. In the past, I have used drugs that had a strong effect on my heart rate, mainly amphetamines in the form of Adderall. Taking more due to tolerance has never caused me to overdose, like he seems to think it could. I have had high blood pressure to the point of getting a ringing sound in my ears, but I believe that this was the result of combining high doses of caffeine with the Adderall...this is not smart, but that is the past and it is what happened. ANYWAY, here is my question: Does tolerance decrease the mental AND physical effects of a drug?
Sorry to bother you guys, I am sure that I am correct, but I couldn't find an answer when I googled this topic (perhaps I didn't look hard enough) and I would like to have better proof than my wordword and experience alone. I am still trying to educate my boyfriend on this topic, for he is fairly new to the realm of really understanding psychoactives.
I am aware that some might feel that this question is stupid. However, I am a big fan of this site and this
has given me reason to create an account. I hope to continue
on here, with better topics/questions/threads.
I am asking because there is a chance that I could be wrong, and I would like to know of I am.
Thank you in advance!

 

[missmeyet?]

I feel certain you are correct.

I can say with absolute certainty that with opiates/opioids when you have a higher tolerance to a drug you will not experience the same effects as you once did at the same dose. Explain to your boyfriend simply this...a person who has never taken a pain pill (or any opiate) might take a normal average dose of say Percocet (oxycodone) 10mg after having a tooth pulled. That same person takes 6 of these 10 mg pills and his breathing will be compromised, it will slow the respiratory rate possibly to a dangerous level.

Person #2 has been taking opiates for years on a regular basis and develops a tolerance. His normal dose for pain relief is say 50mg of oxy. He is definitely not going to have a slowed respiratory rate because his body is accustomed to that dose being his "base level" so to speak. He will get same amount of pain relief at 50mg as person 1 did at 10mg and experience similar reactions.

Someone who is drug naive with no tolerance will experience adverse physical reactions at a much lower dose. If this were not the case then when someone has to have much higher levels of a drug such as 50mg then they would die or have depressed respirations exactly like the naive person. We would never be able to get high again once tolerance is built up because if it affected you physically the way that dose would have done in the beginning we would all croak before we ever got hi again!

 

[Bob Loblaw]

^Aye.


~~> Basic

 

[mrflowers00]

if you take 20mg of something to get where you want to be when you don't have a tolerance when you have to raise that dose to 100mg to get the same effect with a tolerance you will have to worry about the same or more intense unwanted side effects you can't take 10mg of oxycodone at first but then because you have a huge tolerance take 1000mg even if that is what it takes to get the same high that dose will cause significantly more respiratory depression which would probably lead you to stop breathing and go brain dead

 

[psychonautical420]

Thank you for the replies

It seems that one person agrees with me, and the other doesn't... this leads me to still being uncertain.

If anyone else could give their input, it would be greatly appreciated!

 

[PotatoMan]

Drug tolerance is basically how 'use to' your body is to a specific drug. If you take 90mg of codeine to start off, in about 6months of on and off use will have you at 300mg to even feel a nice buzz with like a 1hr or so peak. Your body will just get accustomed to the side effects from the drug and will be able to withstand the effects with higher doses and not feel as fucked up as if someone were to take that dose with no tolerance. That's what I did and I was fuckeddd

 

[mrflowers00]

what i was saying is if you can take 10mg of oxycodone to start with but after a year it takes 300mg to get the same effect after two more years if 1000mg is what it takes to feel the same high that doesn't mean that you will not have a dangerous amount of respiratory depression just because you can handle being on that dose for your high

 

[psychonautical420]

Thanks for the replies, guys