N&PD Moderators: Skorpio | thegreenhand
Ah yes, my good ol' buddy of the Mà Huàng persuasion.
DOUBLE_DEXTER_FINN_AGAIN
(1S,2S)-1-phenyl-1-carbomethoxy-2-methylaminopropane
from
(1R,2S)-1-phenyl-1-hydroxy-2-methylaminopropane
Yes, starting from the (1R,2S)-configuration, the hydroxyl group is converted to a leaving group, such as a mesylate or tosylate. But it's switched back during the second substitution that reacts the resulting compound from the first step with… well I guess something like, α-methoxyacetyl chloride, introducing the carbomethoxy group, no? I'm speculating on the synthetic route a bit here.Actually, I think the hydroxyl group may switch around the stereochemistry of the one spot after it undergoes a substitution reaction.
Pseudoefffffffiiiiii mean pseudomàhuàng, IIRC. Hmm, I'm reminded of PPA and Aminorex synthesis at the moment.Anyway, if that is the case, then this is the correct precursor:
(1S,2S)-1-phenyl-1-hydroxy-2-methylaminopropane
Right? That's how I see it, too. One would start from the (1R,2S) config, and not the pseudo one, (1S,2S).BUT it undergoes 2 substitution reactions, so the former would be correct.
Forgive me for being pedantic and splitting hairs a bit here… The pair of enantiomers with the stereochemistry (1R,2S) and (1S,2R) is traditionally designated "ephedrine", while the pair of enantiomers with the stereochemistry (1R,2R) and (1S,2S) is called "pseudoephedrine". I know you know this already, but I figured it would hurt to post as a reminder to anyone reading this thread… who probs know it too, but … it's in the interests of science and, by extension perhaps if not directly, harm reduction.Errg, Forget Stereochemistry! All I Know Is That Ephedrine Comes In 4 Stereochemicals, And One Of Them Is Correct. Specifically, It Has A (2S).
Probably weak as a stimulant, you're saying, right? And yeah I can't imagine that n-substituted ethylhydroxy bond would do much to help w/potency or even perceptible activity without super high/dangerous doses.
ALCOHOLIC_AMPHETAMINE
N-(2-hydroxyethyl)-1-phenyl-2-aminopropane
Probably weak. I don't know.
These things do affect conversion yield, but ephedrine reduced-meth is S-(+). The question is: how much unconverted ephedrine made it through?I always thought it depended on whether the ephedrine came from ma huang or which brand of cold pills that were used.
Right, two of them are the diastereoisomer, pseudoephedrine.I know there are 2^n where n = 2 chiral centers means that there are 4 possible stereoisomers of ephedrine.
Could be a lot of things.Interestingly, I have found that methamphetamine made from ma huang extract is smoother and weaker than that made from cold pills. I don't know why.
No one is; that's a non-sequitur.But believe it or not, I am not a meth chef.