Benzos Does tobacco screw with the metabolizatiom of ALL benzos?

[《Plasticity》]

So thread title says it all, after doing some reading it appears that tobacco can really fuck with the absorption of alprazolam but does this apply to all benzos? What about thienos? Since etizolam is my benzo of choice can anyone.shed some input on combining the two, Did you noticrle a decrease In effects?

 

[sekio]

Some benzos are not metabolised by the liver - lorazepam, oxazepam, temazepam. But alprazolam is, and that's closest to etizolam, so expect cigarette smoking to alter the effects somehow.

 

[《Plasticity》]

Aww that's a shame, thanks for the info. OT but do you see any contraindications taking kava 10 hours after an aMT trip? I know they're both MAO inhibitors but I have no idea how strong of an MAOI kava is
I'm trying to get to sleep but only have kava around, I'm also pretty much baseline from the aMT. I'd really appreciate a response.

 

[shroomydan]

Aww that's a shame, thanks for the info. OT but do you see any contraindications taking kava 10 hours after an aMT trip? I know they're both MAO inhibitors but I have no idea how strong of an MAOI kava is
I'm trying to get to sleep but only have kava around, I'm also pretty much baseline from the aMT. I'd really appreciate a response.

Does anyone know how tobacco affects metabolism of benzos like alprazolam? Does tobacco shorten the half life or extend it?

 

[Non Nobis Solum]

It's the nicotine!

 

[tricomb]

Depends on whether the benzodiazepine is metabolized via conjugation or glucuronidation.


But yes, empirical research has shown in multiple studies to increase the speed at which your body metabolizes alprazolam as much as 50%, which is cutting your effective dose in half.... I can tell in my body how nicotine decreases the effects of alprazolam, to me it is a very noticeable difference vs no nicotine, which backs up all the research I've read on pubmed over the years.

 

[sigmond]

Depends on whether the benzodiazepine is metabolized via conjugation or glucuronidation.


But yes, empirical research has shown in multiple studies to increase the speed at which your body metabolizes alprazolam as much as 50%, which is cutting your effective dose in half.... I can tell in my body how nicotine decreases the effects of alprazolam, to me it is a very noticeable difference vs no nicotine, which backs up all the research I've read on pubmed over the years.

If you have time I'd appreciate the link to the pubmed research.

Thank you.

 

[《Plasticity》]

^ Relevant studies should be easily found with a bit of googling. Here's a post I found in less than a minute... I cut off a lot of the study to save space though.

http://www.bluelight.org/vb/threads/446477-Xanax-and-Cigarettes-how-long

http://www.ncbi.nlm.nih.gov/pubmed/...nel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Nonlinear mixed effects modeling of single dose and multiple dose data for an immediate release (IR) and a controlled release (CR) dosage form of alprazolam.
Hossain M, Wright E, Baweja R, Ludden T, Miller R.

Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, FDA, Rockville, Maryland 20857, USA.
Cigarette smoking was associated with a 100% increase in clearance of alprazolam as compared to non-smokers

Aww that's a shame, thanks for the info. OT but do you see any contraindications taking kava 10 hours after an aMT trip? I know they're both MAO inhibitors but I have no idea how strong of an MAOI kava is
I'm trying to get to sleep but only have kava around, I'm also pretty much baseline from the aMT. I'd really appreciate a response.

At the time of this post I couldn't find much info on the kava/aMT combo so if for whatever reason somebody stumbles upon this post through google searching this combo the general consensus in another thread I made was that kava was a very weak MAO-B inhibitor and shouldn't have any negative interactions. I successfully combined the two with no problems either. OT but more info on this couldn't hurt, though I'm not sure how popular aMT is after the UK ban.

 

[PotatoMan]

So basically smoking a cigarette will make xanax not work? Im kinda confused.

 

[《Plasticity》]

Smoking tobacco while on xanax will drastically speed up the metabolization of xanax causing your body to expel it far quicker than usual, rendering the xanax a lot less effective than it would have been had you avoided smoking tobacco.

 

[PotatoMan]

This goes for all drugs metabolized by the CYP3A4 enzyme then?

a lot less effective

as in increasing the rate of half-life I assume? So it'll leave the body quicker in other words? Is there a time-frame?

sorry for the high questions

 

[Phat5o]

damn.... i had no idea about this.... but this actually makes sense to me. i was on xanax for 2 or 3 months when i couldn't get my klonopin or valium and i would take an equal dose of xanax, something like 10mg valium i'd equate to .5mg xanax, and i was surprised how fast i'd be back in withdrawal. dosing twice a day wouldn't cut it. and was obviously smoking. this is the only time my tolerance went up and i regret taking xanax for that long.... crazy now that i hear this.
so is it only after you ingest the aprazolam? or does previous nicotine use, a couple minutes earlier have an effect on this as well?

 

[《Plasticity》]

^ Apparently quite a few. Taken from the same thread...

http://www.ncbi.nlm.nih.gov/pubmed/...nel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective.
Desai HD, Seabolt J, Jann MW.

Department of Pharmacy Practice and Pharmaceutical Sciences, Mercer University, Southern School of Pharmacy, Atlanta, Georgia 30341-4155, USA.

Many psychiatric patients smoke, and are believed to be heavier smokers than those without psychiatric disorders. Cigarette smoking is one of the environmental factors that contributes to interindividual variations in response to an administered drug. Polycyclic aromatic hydrocarbons (PAHs) present in cigarette smoke induce hepatic aryl hydrocarbon hydroxylases, thereby increasing metabolic clearance of drugs that are substrates for these enzymes. PAHs have been shown to induce 3 hepatic cytochrome P450 (CYP) isozymes, primarily CYP1A1, 1A2 and 2E1. Drug therapy can also be affected pharmacodynamically by nicotine. The most common effect of smoking on drug disposition in humans is an increase in biotransformation rate, consistent with induction of drug-metabolising enzymes. Induction of hepatic enzymes has been shown to increase the metabolism and to decrease the plasma concentrations of imipramine, clomipramine, fluvoxamine and trazodone. The effect of smoking on the plasma concentrations of amitriptyline and nortriptyline is variable. Amfebutamone (bupropion) does not appear to be affected by cigarette smoking. Smoking is associated with increased clearance of tiotixene, fluphenazine, haloperidol and olanzapine. Plasma concentrations of chlorpromazine and clozapine are reduced by cigarette smoking. Clinically, reduced drowsiness in smokers receiving chlorpromazine, and benzodiazepines, compared with nonsmokers has been reported. Increased clearance of the benzodiazepines alprazolam, lorazepam, oxazepam, diazepam and demethyl-diazepam is found in cigarette smokers, whereas chlordiazepoxide does not appear to be affected by smoking. Carbamazepine appears to be minimally affected by cigarette smoke, perhaps because hepatic enzymes are already stimulated by its own autoinductive properties. Cigarette smoking can affect the pharmacokinetic and pharmacodynamic properties of many psychotropic drugs. Clinicians should consider smoking as an important factor in the disposition of these drugs.

This goes for all drugs metabolized by the CYP3A4 enzyme then?



as in increasing the rate of half-life I assume? So it'll leave the body quicker in other words? Is there a time-frame?

sorry for the high questions

Decreasing the half-life and reducing the effects produced by a dose... for example if you smoke a cigarette then take your xanax it can be 50% weaker and leave the body quicker, at least that's what I took from reading up on the subject. According to the study above this applies to other drugs as well.

 

[tricomb]

^Those are the conclusions I've drawn as well.

 

[Joey24x18]

What about electronic cigarettes?
I'm not a big benzos user, but I have some stashed away for when I have to go through phenibut withdrawal. I vape 12mg e juice pretty heavily. I wonder if It's the nicotine or the 3000 other chemicals in cigarette smoke that causes this lol

 

[dez79]

Definately doesnt interfere with Oxazepam in my experience

 

[Ds]

I got sick as fuck lighting my 'lucky fuck' cigarette backwards, all bar'd out i had already had a headache from earlier, and ate my last 2wagon wheels. Just chilling with my head down ,reach in pocket/pants without even paying attention and fired it up, shit tasted so nasty i puked all over my mothers tomato plants. Had to hose down the porch at like 4am.
My head hurt for the rest of the day.

 

[《Plasticity》]

Definately doesnt interfere with Oxazepam in my experience

The study above proves otherwise. Smoking will cause your body to metabolize oxazepam at a faster rate, thus shortening the duration and (if you're dependant) how long each dose will last before sending you into withdrawal. Up to a full 100% faster if it follows the same path as alprazolam, which it seems like it does.

 

[dez79]

Yes noted the study thanks although Doesnt all stimulants increase metabolism ? therefore caffeine too?

 

[Ds]

Well yeah! Stims make you gofast,going fast = energy, energy costs whatever is n your belly.therefore by moving forward your belly is rumbling,and your wheels begin to move.

So anything that causes shit to keep straight. Like gas in your car,stims in your stomach.