Does the long comeup of 2c-e indicate a psychoactive metabolite?

[perpetualdawn]

Recently I had my first real 2c-e experience, and was surprised at how long the comeup period was - over 3h for me (albiet, I took it orally on a semi full stomach).

This got me thinking, would this be a clue that it's not the 2c-e itself that is psychoactive, but some metabolite of it? Similar slow comeups for mescaline too from what I remember.

 

[sekio]

Not neccesarily, it could just be indicative of crappy pharmacokinetics.

 

[chaos_destroy]

Shulgin once did tests with radio labeled DOB and found that it localises to the lungs before going to the brain which is why it takes so long to come up. Blood goes to your lungs before the brain obviously so if there are receptors there that bind it and hold it there that might explain it. That fact that it doesn't happen with things like psilocin suggests its not 5-ht2a. I have no idea on expression of receptors in the lungs though. It could be being metabolismed in the lungs to something else perhaps but that seems unlikely given how many of them take that long and as far as i know theres no obvious discrepancy between binding affinity and potency between the quick onset and the long onset psychedelics. I mean if they need to be metabolized to be active then doesn't that throughout the idea of 5-ht2a being the main psychedelic receptor given we know they work there?

 

[Seattle_Stranger]

Shulgin once did tests with radio labeled DOB and found that it localises to the lungs before going to the brain which is why it takes so long to come up. Blood goes to your lungs before the brain obviously so if there are receptors there that bind it and hold it there that might explain it. That fact that it doesn't happen with things like psilocin suggests its not 5-ht2a. I have no idea on expression of receptors in the lungs though. It could be being metabolismed in the lungs to something else perhaps but that seems unlikely given how many of them take that long and as far as i know theres no obvious discrepancy between binding affinity and potency between the quick onset and the long onset psychedelics. I mean if they need to be metabolized to be active then doesn't that throughout the idea of 5-ht2a being the main psychedelic receptor given we know they work there?

I wonder if that has something to do with the feeling like someone is vice-gripping your chest whilst on 2c-e.

 

[Hammilton]

No.

I still doubt the idea that DOB goes to the lungs, then the brain. That was one old study and methods have improved s so much from back then.