Gabapentinoids Does pregabalin potentiate valium ?

[youngshaman]

Im on valium 10 mg, low tolerance, I love it for therapetic reasons and the relief and calm feels almost euphoric


Would taking 150mg lyrica on top if it makes it better ?


Or 300 ?


Or more ?


I have experience with lyrica and liked it but never mixed them


Thanks !!

 

[TheLightBringer]

Well yes theyre both sedatives so they would potentiate eachother and ”synergize” so to speak.

If you have prior experience with pregabalin you can take 300mg without issue, the combination will likely feel closer to a pharma/pill version of alcohol.

Keep in mind the combination will be stronger than either drug by themselves, so if you need to operate machinery or appear sober id save it for when youre just chilling at home but you probably already know all this

 

[placebonaut]

yes they interact and I find pregabalin potentiates diazepam (valium) significantly - google "diazepam channel", and separately for "pregabalin channel" for a more detailed explanation as to why and how they work but their method of effect is different

I can easily take 60mg of diazepam + 2mg xanax + cannabis + alcohol and not feel a great deal to be honest.

but 300mg of pregabalin + 20mg of diazepam has me in my happy place, the effect of the diazepam is significantly amplified for me when combined with pregabalin.

I consider myself to have no tolerance to either pregabalin or benzos.

tolerance to both builds much quicker than it appears, and I've read enough about benzo WD to be scared as fuck to abuse it....

When you say "you're on 10mg of Valium" do you mean every day? be careful....I take 300mg of pregablin once per week and feel the need to take tolerance breaks once a month. General hive mind consensus is avoid benzos and take them more as a way to combat the negative effects of stims

 

[Señor Moreno]

Don't know if "potentiate" is the word, as in benzos potentiate opioids, but there's definitly a synergy (sp?) between diazepam and pregabalin

 

[evo4ever]

I've taken this combo before and I've always found myself asleep at my computer desk lol so be careful!

 

[Dextro .45]

Diazepam 10mg would be pleasantly potentiated by a low ish therapeutic dose of Pregabalin 150mg is fine

On an empty stomach/fasted state 90% oral bioavailability and 1h C-Max …..on a fed state/heavy meal it takes 4 hours to reach peak serum levels

Valium 10mg + Lyrica 150mg capsule = Amazing anxiolytic & mood-boosting properties

 

[placebonaut]

Don't know if "potentiate" is the word, as in benzos potentiate opioids, but there's definitly a synergy (sp?) between diazepam and pregabalin

think potentiate might actually be the correct term here from a pharmacology perspective - but I'm a layman so happy to be corrected, but think it's just a general term that 1 drug enhances the effect of another.

On an empty stomach/fasted state 90% oral bioavailability and 1h C-Max …..on a fed state/heavy meal it takes 4 hours to reach peak serum levels

Empty stomach is key for pregab otherwise the onset is just too bloody long. I generally go with 300mg taken 1st thing in the morning (like as soon as I wake up), snorting works faster but I find the high is a bit sharper and more synthetic (I mainly tend to use it if my tolerance is too high and find a need a bigger kick, I take pregab once per week for 3 weeks, 1 week off, then restart), or if I want to push the pregabs own high much more, at 900mg you get some visuals at times.

I then take diazapam sublingually because I love the taste! duration for both of these is similarish so works pretty well together - I take this combo as it helps calm down the pregabs tendency to give you super focus on activities if you'd just prefer to chill out with it. but if you have shit to get done pregab's a great thing on it's own.

it's a great and fun combo to use as a base, I will often through the day add in additional things depending on my mood using the half life of other drugs as a way to manage moving from 1 type of high to another. Weed (almost always), coke then later mephedrone the later soma to chill out with, some ket is nice too (I'm dosing small here and am pretty experienced with each on their own and in combos with pregab+diazapam, titrate up and know your shit before fucking about please), with the exception of weed I don't mix these together and let the effect wear off before I swap to something else. Doing the same thing but without diazapam is different and fun as well, but I like how diazapam smooths things out and stops the hyperactivity phase of pregab.

Going from memory here but think this is correct - 1 other call out, your body can only absorb a max amount of pregab (900mg) after which you just piss the rest out. I've done 900mg after a tolerance break a few times, it's fun, but I generally prefer lower dosing of things given I'm a combo guy, I'm chasing a specific overall effect and using a cocktail to achieve it.

 

[TheLightBringer]

think potentiate might actually be the correct term here from a pharmacology perspective - but I'm a layman so happy to be corrected, but think it's just a general term that 1 drug enhances the effect of another.


Empty stomach is key for pregab otherwise the onset is just too bloody long. I generally go with 300mg taken 1st thing in the morning (like as soon as I wake up), snorting works faster but I find the high is a bit sharper and more synthetic (I mainly tend to use it if my tolerance is too high and find a need a bigger kick, I take pregab once per week for 3 weeks, 1 week off, then restart), or if I want to push the pregabs own high much more, at 900mg you get some visuals at times.

I then take diazapam sublingually because I love the taste! duration for both of these is similarish so works pretty well together - I take this combo as it helps calm down the pregabs tendency to give you super focus on activities if you'd just prefer to chill out with it. but if you have shit to get done pregab's a great thing on it's own.

it's a great and fun combo to use as a base, I will often through the day add in additional things depending on my mood using the half life of other drugs as a way to manage moving from 1 type of high to another. Weed (almost always), coke then later methedrone the later soma to chill out with, some ket is nice too (I'm dosing small here and am pretty experienced with each on their own and in combos with pregab+diazapam, titrate up and know your shit before fucking about please), with the exception of weed I don't mix these together and let the effect wear off before I swap to something else. Doing the same thing but without diazapam is different and fun as well, but I like how diazapam smooths things out and stops the hyperactivity phase of pregab.

Going from memory here but think this is correct - 1 other call out, your body can only absorb a max amount of pregab (900mg) after which you just piss the rest out. I've done 900mg after a tolerance break a few times, it's fun, but I generally prefer lower dosing of things given I'm a combo guy, I'm chasing a specific overall effect and using a cocktail to achieve it.

Thats quite the combo, when you wrote methedrone did you mean actual methedrone as in 4-MethoxyMethcathinone, or Mephedrone as in 4-MethylMethcathinone?
Or did you mean Methadone?


Pregabalin + Diazepam + Weed + Coke + either 4-MMC or Methadone + Carisoprodol sounds absolutely heavenly though

 

[placebonaut]

Thats quite the combo, when you wrote methedrone did you mean actual methedrone as in 4-MethoxyMethcathinone, or Mephedrone as in 4-MethylMethcathinone?
Or did you mean Methadone?


Pregabalin + Diazepam + Weed + Coke + either 4-MMC or Methadone + Carisoprodol sounds absolutely heavenly though

good spot, have edited my post, it was Mephedrone as in MCAT.

just to be clear I'm not taking them all at the same time, the coke will have warn off before I take mephedrone (maybe a bit of overlap at times). Ditto I only use Soma on the comedown from stims, but the pregab and dizzy is still very much active.

it's quite a cocktail, needs care!

 

[Halif2]

it's quite a cocktail, needs care!

It sure does. I've been uhhh experimenting recently with doses of Lyrica, Soma, and a benzo (usually Xanax), and it really gets you to sleep. I've pregab to go great with a variety of benzos (most commonly tested are alprazolam, temazepam, diazepam, and lorazepam). Knowing that there's real potentiation from tje benzos, I tend to be careful and half or even a third of a usual dose.

One interesting thing happened: The lorazepam (Ativan) does not act like the others.

Any of the others mentioned will lead to me getting loose (physically) as there's great muscle relationship going on, getting drowsy, and getting a bit wobbly / unbalanced.

The lorazepam put me into an 'interesting' loop of essemtially nodding out and having micro-blackouts. It happens very, very quickly. One second I'm sitting at the compjter, then without even notcing I'm in the office trying to find a file that missing; Then I'll open my eyes and I'm back in front of the computer, but now there's a plate of dinner there/ Before I can dwell on it I'm off again to some other place for seconds, minutes? Then I snap awake because I've managed to my dinner into my lap.

I have regular pharma Ativan (2.5mg per tablet).

Anyone else had weird experiences with Ativan and Soma and/or Lyrica?

 

[placebonaut]

It sure does. I've been uhhh experimenting recently with doses of Lyrica, Soma, and a benzo (usually Xanax), and it really gets you to sleep. I've pregab to go great with a variety of benzos (most commonly tested are alprazolam, temazepam, diazepam, and lorazepam). Knowing that there's real potentiation from tje benzos, I tend to be careful and half or even a third of a usual dose.

pregab + xanax + soma = just knocks me out as well, I've stopped doing that combo, but with diazepam instead of xanax at equivalent dosage and I'm fine. Xanax doesn't usually make me drowsy like that at triple the dose.

 

[daturetard]

Don't know if "potentiate" is the word, as in benzos potentiate opioids, but there's definitly a synergy (sp?) between diazepam and pregabalin

I think you have it backwards. Benzos dont potentiate opioids. They have additive effects, as they do not work on the same receptor (i mean perhaps some downstream gaba activation from opioids, but not significantly enough for it to be considered a true potentiator). Potentiation is multiplicative as opposed to additive, like (just for example and absolutely not recommended) if you were to take a barbiturate with a benzo, as the barbiturate widens the gate of the ion channel on the GABAA receptor that the gaba flows through, and the benzo holds the gate open longer. Both allow more GABA to flow through, but in different ways, so they are directly potentiated via each other.
Both are positive alloesteric modulators, but work in different ways so rather than adding effects, they multiply.

This might make more sense if explained with muscimol replacing the barb or benzo.

Let's use the benzo for this example as they're more common at this point and much safer. So the benzo is going to hold the ion gate open longer, (though still open at the same dilation as if you had no drugs in your system, so less gaba is coming through at once than if it were a barbiturate, being a reason they're safer) so more GABA is allowed to flow through the gate. The muscimol is a direct agonist of GABAA and functions much the same as the neurotransmitter itself. So when more GABA is allowed through this gate, so is more muscimol.

Drug potentiation occurs when one drug you have consumed has a direct multiplicative influence on another drug youve consumed.
When one drug directly makes another drug stronger than it would be without the second drug in the mix.

I hope this doesnt come off preachy, just wanted to try and help some peoples understanding.

 

[Señor Moreno]

Thanks, probably I misunderstood the semantic meaning of the words, in English I mean.
What I meant is that benzos makes opioids effects stronger, not in the anaelgesia but in CNS depression and the subjetive high, too. A baggie wasn't enough for me to be well when a was an addict, but using it with rohypnol that baggie became enough. It made it stronger and more dangerous.
Using benzos and pregabs what I felt is that they both worked better; both drugs' effects were more satisfactory. They also felt stronger, but in harmonious synergy.
That's what I meant, but don't know what fits better with the meaning of potentiation

 

[lost weekend]

Pregablin,clonazepam and alcohol wasn't a great mix for me
I was only taking pregablin for a week but it made me stay up longer than I normally would ,
I tried to pm a guy on face book at 3.30 am about buying my van calling him a c£^# for not answering but I posted it on main page
My sister phoned me in the morning telling me everyone could see it and to take it down
I was addiment it wasn't me as I had zero recollection of it .

 

[CasualCrackSmoker69]

Im on valium 10 mg, low tolerance, I love it for therapetic reasons and the relief and calm feels almost euphoric


Would taking 150mg lyrica on top if it makes it better ?


Or 300 ?


Or more ?


I have experience with lyrica and liked it but never mixed them


Thanks !!

If you enjoy the anxiety relief of valium you will probably enjoy pregabalin. Take caution though, pregabalin is more addictive than benzos and have terrible withdrawals if you were to use it more then maybe twice a week.

If its your first time take 300mg and you will get a feel for it. Maximum prescribed dose is 600mg/day (at least where I live) so you are within safe dosage going for the 300.

The combo of pregabalin and valium is maybe not the best idea though. Those two will boost each other which comes with risks.

If you can, take the pregabalin before you eat anything. It will hit harder on an empty stomach. It should go without saying but of course eat something after taking the pills!

Good luck soldier, I hope you find what you are looking for.

 

[WellTram]

If you enjoy the anxiety relief of valium you will probably enjoy pregabalin. Take caution though, pregabalin is more addictive than benzos and have terrible withdrawals if you were to use it more then maybe twice a week.

If its your first time take 300mg and you will get a feel for it. Maximum prescribed dose is 600mg/day (at least where I live) so you are within safe dosage going for the 300.

The combo of pregabalin and valium is maybe not the best idea though. Those two will boost each other which comes with risks.

If you can, take the pregabalin before you eat anything. It will hit harder on an empty stomach. It should go without saying but of course eat something after taking the pills!

Good luck soldier, I hope you find what you are looking for.

Yes i feel withdrawals after just few days of taking pregabaline. But I like the effects. Diazepam is my daily classic. Sometimes i take 300mg and other day 30mg, it doesn't produce withdrawals after +- 10 hour like alprazolam. It is subtly doing its job and u will feel the dose on the next day even more than on the first day. It accumulates in body and slowly getting back into bloodstream.
I also find that now Xanax doesn't give me that both body and mind relief from tension as does Valium even if I take higher than equivalent dose.

 

[lost weekend]

If you enjoy the anxiety relief of valium you will probably enjoy pregabalin. Take caution though, pregabalin is more addictive than benzos and have terrible withdrawals if you were to use it more then maybe twice a week.

If its your first time take 300mg and you will get a feel for it. Maximum prescribed dose is 600mg/day (at least where I live) so you are within safe dosage going for the 300.

The combo of pregabalin and valium is maybe not the best idea though. Those two will boost each other which comes with risks.

If you can, take the pregabalin before you eat anything. It will hit harder on an empty stomach. It should go without saying but of course eat something after taking the pills!

Good luck soldier, I hope you find what you are looking for.

Your right only an idiot would consciously mix the 3 especially knowing the inevitable results .
My time for experimenting with 3 similar drugs should have ended 25 years ago lol