Does potency of a chemical affect the caliber of an allergy attack?

[SayWhatHEH]

I'm finding it slightly difficult to word my question so I will try to use an example. Fentanyl's effects occur at a very small dose, in the micrograms if I'm correct. Codeine's effects occur after a much larger dose relative to the fentanyl.

If I hypothetically was allergic to both chemicals and had both chemicals in pure form and ingested the same weight of each on separate occasions... Would the fentanyl cause a stronger allergic reaction because it is more potent?
Were speaking hypothetically so please don't try to tell me that taking a fentanyl dose at the same weight as an active codeine dose would be dangerous because that's irrelevant.

 

[sekio]

Allergies are mediated by the immune system and its reaction to foreign substances. It has nothing to do with the potency of the drugs, and an allergy to codeine will not neccesarily result in a reaction to fentanyl or vice versa.

If someone is allergic to both peanuts and gluten, what will cause a bigger allergic reaction, 10 grams of peanut oil, or 10 grams of gluten? Depends on the individual. The answer to your question is "No."