Does Latuda or generic increase serotonin and/or is it an SSRI?

[Omlovepeace]

Does Latuda increase serotonin and/or is it an SSRI?

 

[someguyontheinternet]

Latuda is am antipsychotic which interacts with 5ht1a where it is a partial agonist along with 5ht2a and 5ht7 where it is an antagonist.

The partial agonism at 5ht1a may decrease serotonin release because that is a presynaptic autoreceptor which detects when there is excess serotonin in the synapse and shuts down vesicular release

 

[Omlovepeace]

Wow, thanks. You're very intelligent. Can you please tell me what it does to 5ht7? Can you please briefly describe the difference between antagonist and agonist?

 

[someguyontheinternet]

An agonist activates a receptor, just like serotonin would. It may or may not activate it as much as serotonin and when its less, that's a partial agonist. An antagonist blocks the receptor from being activated, there can be different kinda of antagonists such as competitive or non competitive. Competitive antagonists compete for the same binding site as serotonin and with enough serotonin it could be displaced and activated. Non competitive cannot be displaced by serotonin.

It acts as an antagonist at 5ht7 but I don't know whether its competitive or not or what the role of 5ht7 antagonism is in terms of the pharmacological effect