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Stimulants Does consistent opiate use augment post-amphetamine depression?

I Eat Pho

Bluelighter
Joined
Nov 9, 2010
Messages
298
Location
NYC
Simply put, I am wondering if consistent opiate use can have an affect on the intensity of the negative aspects of a comedown from amphetamines. To not be so vague, I will give you my specific situation:

My heroin use: 3-4 times throughout the week. Sometimes go on 7 day binges where I use 1-2 times a day but then sometimes I will go a whole week without using at all . It has been this way for about 4 months. Pretty random.

My amphetamine/amp analog use
: I have been experimenting with various RC's over the past 6 months.. mainly 4-FA, Methylone, MPA, Camfetamine, 6-APB, and a very brief stint with MDPV (or satan's snots as I call it). Use only 1 of these about once every 6 weeks.. sometimes more time between but other times I've let less time go in between.

Now I am somewhat educated on the effects that amps/amp analogs have on your serotonin and dopamine levels. I realize that the larger the interval between use the better. Since experimenting with 4-FA and Methylone (starting using these prior to the dope) I always felt like shit the next day (naturally) but that was it. I Never had any lingering depression days after. However, ever since I started using dope I have gotten some severe depression for like a 4-5 days after using one of the stimulants. Also, it is important to point out that I have also let less time go by in between dosing the stims.

So I'm not really sure if this residual depression has been caused by my not taking enough breaks in between dosing stims or if the dope has an effect on it. I know that it is ideal to let at least 2 months go in between dosing the amps/amp analogs and even more time is better.. but I haven't done that. I have, however, been trying not to use the same RC back to back (example: July I dosed with 4-FA.. Aug I dosed with Camfetamine.. and still had shitty depression for almost a week after). Now don't get me wrong. During the depression stage if I used dope I was not sad while I was high but once it wears off or even worse the next morning I wanted to die.

Any help/info anyone has would be great. I'm very interested in the pharmacology on how these substances affect your dopamine/serotonin levels so any info in this area would be very welcoming.

Thanks,
Pho
 
Opiate usage will definitely mask the negative effects of amphetamine withdrawal, but that's really digging one holl to fill another, you know? You'll end up with an opiate dependency and then have to find something to substitute for it too, etc. It's a neverending cycle.

Don't get too dead set on the monoamine hypothesis of mood/depression either. It doesn't hold true in a lot of cases.
 
Hi Sekio, thakns for the response. You say amphetamine "withdrawl" though. I am not talking about withdrawl as I only use the amps about once every 6-8 weeks..sometimes even more time goes between taking any amps. I literally mean I take 1 dose every 6-8 weeks.. not binges every 6-8 weeks. Just want to clarify because I am not going through amp withdrawl, just the negative effects after rolling for a night.
 
So, basically you're just asking if opiate use will curve the comedown of an amphetamine high? Of course! But, I'd be very, very careful with the heroin, man.. It's very easy to fall into a pattern which you sound like you're already getting into.
That's really the only negative I have with amps is starting to comedown, makes me feel terrible.
 
Hi there. From reading your brief synopsis of your current drug intake, And I demaybe completely wrong here. And I apologise beforehand if that is the case. But I think you have to consider that your depression is already there, which is why your using more frequently now. The result of which is to magnify that small underlying depression, making it worse. Its a vicious circle, with depression causing drug use. Then drug use causing more depression. All of which maybe wrong. In that case, then at the moment the drugs your taking are doing what all drugs do. That is to amplify how your feeling. Because both of those substances can produce depression. If you stopped the amphetamine you will still feel depressed from the gear and vice-versa. How long have you been taking each thing by the way.
Ok. I doubt that was much help. But from experience I know that all the drugs do is to show how your really feeling. And its better to address the underlying problem on its own. You cant bury it with substances. I've tried and they don't help to actually solve the issues.
I wish you the very best. And the good thing is you've identified a problem and If your strong enough to just take gear 3 or 4 times a week. Then I've every confidence that you wont let this become something bigger than it actually is. Take care. Al.
 
So, basically you're just asking if opiate use will curve the comedown of an amphetamine high? Of course! But, I'd be very, very careful with the heroin, man.. It's very easy to fall into a pattern which you sound like you're already getting into.
That's really the only negative I have with amps is starting to comedown, makes me feel terrible.
Thanks man. I'm not gonna be one of those guys that says "thanks but i'm being careful". I already see it starting to happen. I haven't touched it in 2 weeks though. I am not planning on it either for awhile.. I'd be lying if I said I don't think about it but I have plenty of other things (work, gf, hobbies, other drugs) to keep me distracted so far. I knew exactly what I was getting into before I started. I am not new to opiates at all.. just new to H and the needle.. which in my opinion is almost like a whole new drug.
 
Good stuff, man. Glad to see that you actually realize what could happen, that's very refreshing. Nothing like a fat shot of IV heroin to curve an amphetamine comedown :).
 
Hi there. From reading your brief synopsis of your current drug intake, And I demaybe completely wrong here. And I apologise beforehand if that is the case. But I think you have to consider that your depression is already there, which is why your using more frequently now. The result of which is to magnify that small underlying depression, making it worse. Its a vicious circle, with depression causing drug use. Then drug use causing more depression. All of which maybe wrong. In that case, then at the moment the drugs your taking are doing what all drugs do. That is to amplify how your feeling. Because both of those substances can produce depression. If you stopped the amphetamine you will still feel depressed from the gear and vice-versa. How long have you been taking each thing by the way.
Ok. I doubt that was much help. But from experience I know that all the drugs do is to show how your really feeling. And its better to address the underlying problem on its own. You cant bury it with substances. I've tried and they don't help to actually solve the issues.
I wish you the very best. And the good thing is you've identified a problem and If your strong enough to just take gear 3 or 4 times a week. Then I've every confidence that you wont let this become something bigger than it actually is. Take care. Al.

I do sincerely appreciate your concern and advise. I don't think it is out of reach for you to assume that based on my very short paragraph but I do want to clarify because a) nobody seems to be addressing my very specific question and b) so far i'm hearing only concern about my drug use.. and while I appreciate it, you are wrong in assuming my depression and reasons for using.

I have been using drugs since high school (now 27) and have always only used them for recreational purposes and NEVER (I can't think of one incident.. and I believe I'm very honest with myself) once did i use as an escape. The H is the first substance where I started using one thing (aside from weed) on a regular basis. I am fully aware that it has started to become a habit. I totally see it because using 3-4 times a week is not something I would have imagined I would ever do. So I am aware and trying to make the necessary changes to stop that habit aka stop using H which for the past 2 weeks I've been successful. I think about it occasionally but I am not craving or dying for it by any means. It has already gotten easier by week 2. I want you to know that I do not feel depressed feelings outside of the amphetamine comedown. I am not depressed in normal life, i do not take SSRI's or ANY medication for that matter. I barely even take advil. I only feel this weird depressed feeling after rolling or after taking any of the amp analogs I mentioned above (which in my research is pretty normal.. i've known this since high school).

Now onto my question in case I didn't explain it well in my first post. I literally just want to know if having opiates in your system (from somewhat consistent use) will actually effect or enhance the come down of amphetamine comedown (aka the negative depressed feelings which is common with amphetamine comedown due to serotonin depletion..or whatever).

Thanks
 
Your right. Sorry about that. So? Lets try and answer the question. And this is only from personal experience. I think if you have some opiate residue in your system or are even starting to cluck a little bit. Then, yes i do think that it could make the depression worse. If that's the case, then I recommend taking more gear. Just until the amphetamine comedown has worn off. Who knows? But that's what i would do. Just go with the flow.
 
p.s. Why not try mixing the two together. That's quite nice. You could even try using some methadone on those occasions. Just so you'll know for sure if it is just the amphetamine on its own causing the issues.
 
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So I know it is pretty normal to feel residual depression after a dose of amphetamine analogs.. especially if the person is using them more often. That has been a widely accepted fact and just part of the territory. The thing is I never really used to get residual depression after taking MDMA, 4-FA or any of the drugs I mentioned in my original post until recently which is when I started using the amphetamines a little more often than I used to and at the same time started using dope.

Now I considered myself a chipper when it came to dope, and I never really felt any withdrawl symptoms but I have heard that heroin addicts do feel great depression once the initial physical withdrawl symptoms subside. I am wondering if I was feeling a mild version of that.. while at the same time the come down depression from the amps. Just a thought.
 
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