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Does BHT have GABAergic effects?

wungchow

wungchow

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I noticed that the structure of butylated hydroxytoluene (BHT) is strikingly similar to that of propofol. Do they share similar effects?
 
Wow, Never noticed that. If I'm remembering right (this is the 30 minutes I have to spend with my wife today) that methyl group will be bad for potency. A halogen there would be beneficial in terms of effect (more benzo v. barb)
 
wungchow said:
I noticed that the structure of butylated hydroxytoluene (BHT) is strikingly similar to that of propofol. Do they share similar effects?
Click to expand...

ionol is BHT.

Farmakol Toksikol. 1987 May-Jun;50(3):21-4.
[Dissociation of the anti-amnesic and antihypoxic effects of nootropic and antihypoxic preparations][Article in Russian]


Voronina TA, Garibova TL, Khromova IV, Tilekeeva UM.
In experimental studies on mice it was shown that piracetam, Cleregil, centrophenoxine, pyritinol possessed the most pronounced anti-amnestic activity. A close effect was noted with Euclidan, 3-hydroxypyridine and ionol. GABAergic agents (sodium oxybutyrate, phenibut, pantogam), gutimine, nicotinoyl-GABA eliminated amnesia to a lesser extent. The antihypoxic effect on the model of hypobaric hypoxia was exerted by typical antihypoxic agents (gutimine, sodium oxybutyrate, 3-hydroxypyridine). The antihypoxic activity of nootropic drugs (centrophenoxine, pyritinol, phenibut) could be determined only at a significant increase of doses. No interrelationship and the presence of dissociation in manifestation of anti-amnestic and antihypoxic effects were revealed.
 
wungchow said:
butylated hydroxytoluene (BHT)
Click to expand...
Am I the only one who has difficulties in imaginating how this one is supposed to look like?
Hydroxytoluene: Hydroxylated - where? ortho/meta/para? At the methyl not, I guess, as it would be benzylic alcohol then.
Butylated: Same problem: Where is the butyl supposed to stick to?

Sorry, early in the morning my brain is still booting up, like an old 80286er...
 
murph

it is 2,6-di-tertbutyl-4-methylphenol.

toxicity wise at 2-5g or so in humans causes cramps nausea vomiting gastritus and a whole host of nasty effects. this is known because of people using it as a treatment for herpes, cancer and other ailments for which there is no evidence of efficacy.

the only thing it is good for is preventing fatty things going rancid and ether making peroxides
 
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